Fabrication, characterization and properties of DHA-loaded nanoparticles based on zein and PLGA

Liu, Enchao; Su, Zhen; Yang, Czau‐Siung; Ji, Yuan; Liu, Bingjie; Meng, Xia

doi:10.1016/j.foodchem.2021.129957

Cited by 20 publications

(11 citation statements)

References 32 publications

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“…The possible reason was that the hydrogen bonds and electrostatic interactions between PLA and chitosan/zein made the structure more compact and avoided DHA oxidation. The water solubility of DHA nanoparticles was 750 times that of free DHA, which may be because the hydrophilic heads (-COOH and -OH) of PLA significantly increased the water solubility [ 20 ].…”

Section: Delivery Systems Of Dhamentioning

confidence: 99%

Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review

2022

Foods

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Docosahexaenoic acid (DHA), mainly found in microalgae and fish oil, is crucial for the growth and development of visual, neurological, and brain. In addition, DHA has been found to improve metabolic disorders associated with obesity and has anti-inflammatory, anti-obesity, and anti-adipogenesis effects. However, DHA applications in food are often limited due to its low water solubility, instability, and poor bioavailability. Therefore, delivery systems have been developed to enhance the remainder of DHA activity and increase DHA homeostasis and bioavailability. This review focused on the different DHA delivery systems and the in vitro and in vivo digestive characteristics. The research progress on cardiovascular diseases, diabetes, visual, neurological/brain, anti-obesity, anti-inflammatory, food applications, future trends, and the development potential of DHA delivery systems were also reviewed. DHA delivery systems could overcome the instability of DHA in gastrointestinal digestion, improve the bioavailability of DHA, and better play the role of its functionality.

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Section: Delivery Systems Of Dhamentioning

confidence: 99%

Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review

2022

Foods

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“…In this study, CD spectrum analysis was applied to measure conformational changes (secondary structure) of zein in complexation (260 nm~190 nm). As seen from (Figure 4C), two peaks at 209 and 223 nm with a zero-crossing were around 203 nm (typical secondary structure) in the zein spectrum [44]. As shown in (Table 2), the α-helix, β-sheet and β-turn content of DHF-S/Z changed from 25.3 to 24.7 and 24.5%, 25.8 to 26.1 and 26.6% and 28.3 to 29.1 and 27.9%, respectively after adding CMC and ALG.…”

Section: Spectrummentioning

confidence: 75%

Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose

Chen

Peng

Wang

et al. 2021

Foods

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In this study, two polysaccharides [sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)] were selected to establish zein/sophorolipid/ALG (ALG/S/Z) and zein/sophorolipid/ALG (CMC/S/Z) nanoparticles to encapsulate 7,8-dihydroxyflavone (7,8-DHF), respectively. The results showed that polysaccharide types significantly affected performance of ternary nanoparticles, including CMC/S/Z possessed lower polydispersity index, particle size and turbidity, but higher zeta potential, encapsulation efficiency and loading capacity compared to ALG/S/Z. Compared to zein/sophorolipid nanoparticles (S/Z), both ALG/S/Z and CMC/S/Z had better stability against low pH (pH 3~4) and high ionic strengths (150~200 mM NaCl). Hydrophobic effects, electrostatic interactions and hydrogen bonding were confirmed in ternary nanoparticles fabrication via Fourier-transform infrared spectroscopy. Circular dichroism revealed that CMC and ALG had no evident impact on secondary structure of zein in S/Z, but changed surface morphology of S/Z as observed by scanning electron microscope. Encapsulated 7,8-DHF exhibited an amorphous state in ternary nanoparticles as detected by X-ray diffraction and differential scanning calorimetry. Furthermore, compared to S/Z, ALG/S/Z, and CMC/S/Z remarkably improved the storage stability and bioaccessibility of 7,8-DHF. CMC/S/Z possessed a greater storage stability for 7,8-DHF, however, ALG/S/Z exhibited a better in vitro bioaccessibility of 7,8-DHF. This research provides a theoretical reference for zein-based delivery system application.

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“…Several studies have assessed DHA-loaded nanoparticle properties [ [27] , [28] , [29] ]. These materials can be synthesized by dissolving DHA in ethanol and adding it into casein solution.…”

Section: Introductionmentioning

confidence: 99%

Docosahexaenoic acid-loaded nanoparticles: A state-of-the-art of preparation methods, characterization, functionality, and therapeutic applications

Ali,

Hachem,

Ahmmed

2024

Heliyon

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Fabrication, characterization and properties of DHA-loaded nanoparticles based on zein and PLGA

Cited by 20 publications

References 32 publications

Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review

Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review

Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose

Docosahexaenoic acid-loaded nanoparticles: A state-of-the-art of preparation methods, characterization, functionality, and therapeutic applications

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