Fabrication, characterization, and in vivo biocompatibility evaluation of titanium-niobium implants

Abstract

In this study, biocompatible titanium-niobium (Ti-Nb) alloys were fabricated by using powder metallurgy methods. Physical, morphological, thermal, and mechanical analyses were performed and their in vivo compatibility was evaluated. Besides α, β, and α″ martensitic phases, α+β Widmanstätten phase due to increasing sintering temperature was seen in the microstructure of the alloys. Phase transformation temperatures of the samples decreased as Nb content increased. The ratio of Nb in the samples affected their mechanical properties. No toxic effect was observed on implanted sites. This study shows that Ti-Nb alloys can be potentially used for orthopedic applications without any toxic effects.

Evaluation of Microstructure and Mechanical Properties of a Ti10Mo8Nb Alloy for Biomedical Applications

“…Vanadium in its elemental state is considered toxic and it is being correlated to cases of neurological disorders (e.g., Alzheimer's) and organ inflammation [14,15]. Niobium, on the other hand, does not show this toxicity, although it maintains the same effect as a β stabilizing agent [16,17]. Moreover, the production of niobium has a strong relationship with Brazil, since the country has 16 million tons of that material, accounting for 91% of its production globally.…”

Polyoxometalates as Effective Nano-inhibitors of Amyloid Aggregation of Pro-inflammatory S100A9 Protein Involved in Neurodegenerative Diseases

“…Moreover, oxide-covered Nb and Ta devices have shown high biocompatibility without known adverse effects in the orthopedic and dental implants. 74 − 77 …”

“…Thus, polyoxoniobates have been proven to be highly attractive candidates for biological applications, including the treatment of amyloid and neurodegenerative diseases. Moreover, oxide-covered Nb and Ta devices have shown high biocompatibility without known adverse effects in the orthopedic and dental implants. − …”

Comparison of osseointegration of Ti–Al6V4 and Ti–Al6Nb7 implants: An experimental study

“…Shapira et al reported that the negative effects of the V resulted in the higher BIC ratios with the Ti-Al 6 Nb 7 implants than with the Ti-Al 6 V 4 implants. Additionally, in their recent biocompatibility study, Yolun et al 18 evaluated the biocompatibility of Ti Nb implants in vivo. They reported that Nb increased the mechanical properties of the implant and had no toxic effects, thereby demonstrating that Nb implants could be used orthopedically.…”