Comparison of osseointegration of Ti–Al6V4 and Ti–Al6Nb7 implants: An experimental study

Bozoğlan, Alihan; Dündar, Serkan

doi:10.1016/j.jobcr.2021.09.012

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Concerning TiAl6V, the possibility of vanadium and aluminum release limits its use. Indeed, vanadium has a cytotoxic effect, while aluminum has significant neurotoxic effects and can induce Alzheimer's disease, bone fragility, and local inflammation [50,51]. Hypersensitivity reactions are also reported.…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility of ZrO2 vs. Y-TZP Alloys: Influence of Their Composition and Surface Topography

et al. 2022

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The osseointegration of implants is defined as the direct anatomical and functional connection between neoformed living bone and the surface of a supporting implant. The biological compatibility of implants depends on various parameters, such as the nature of the material, chemical composition, surface topography, chemistry and loading, surface treatment, and physical and mechanical properties. In this context, the objective of this study is to evaluate the biocompatibility of rough (Ra = 1 µm) and smooth (Ra = 0 µm) surface conditions of yttria–zirconia (Y-TZP) discs compared to pure zirconia (ZrO2) discs by combining a classical toxicological test, morphological observations by SEM, and a transcriptomic analysis on an in vitro model of human Saos-2 bone cells. Similar cell proliferation rates were observed between ZrO2 and Y-TZP discs and control cells, regardless of the surface topography, at up to 96 h of exposure. Dense cell matting was similarly observed on the surfaces of both materials. Interestingly, only 110 transcripts were differentially expressed across the human transcriptome, consistent with the excellent biocompatibility of Y-TZP reported in the literature. These deregulated transcripts are mainly involved in two pathways, the first being related to “mineral uptake” and the second being the “immune response”. These observations suggest that Y-TZP is an interesting candidate for application in implantology.

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Section: Discussionmentioning

confidence: 99%

Biocompatibility of ZrO2 vs. Y-TZP Alloys: Influence of Their Composition and Surface Topography

et al. 2022

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“…Other investigations have reported that the use of a Ti–26Nb (at.%) alloy not only reduces the Young module, but reveals high biocompatibility on osteoblast cells, comparable to control or cells growing onto TiCp [ 37 , 38 ]. Because niobate ions are less toxic than the vanadate ones and niobium-based alloys promote cell-to-cell interactions, niobium may be used as alternative material to vanadium in the design of future titanium alloys [ 10 , 14 , 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, these materials may release their corresponding ions that can be toxic to the surrounding tissue, and therefore limit their clinical use. Indeed, previous studies have demonstrated that vanadium and aluminum exhibit cytotoxic effects and aluminum is involved in Alzheimer’s disease pathogenesis, bone fragility and local inflammation [ 13 , 14 ]. A recent study reported that nanostructures on the machined transgingival part of titanium implants may influence the surrounding tissue and require extensive preclinical basic research to gain clinical relevance [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

et al. 2022

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Titanium dental implants have common clinical applications due to their biocompatibility, biophysical and biochemical characteristics. Although current titanium is thought to be safe and beneficial for patients, there are several indications that it may release toxic metal ions or metal nanoparticles from its alloys into the surrounding environment, which could lead to clinically relevant complications including toxic reactions as well as immune dysfunctions. Hence, an adequate selection and testing of medical biomaterial with outstanding properties are warranted. This study was designed to explore the biocompatibility of smooth titanium-niobium alloy (S_TiNb) versus smooth titanium commercially pure (S_TiCp)—a reference in implantology. All experiments were performed in vitro using human osteoblast-like SaOs-2 and monocyte THP-1 cell lines as models. Cell adhesion and growth morphology were determined by scanning electron microscopy, while cell viability was evaluated using WST-1 assay. Because niobate anions or niobium nanoparticles can be released from implants during biomaterial-cell interaction, potential immunotoxicity of potassium niobate (KNbO3) salt was evaluated by examining both metabolic activity and transcriptomic profiling of treated THP-1 monocytes. The main findings of this study are that S_TiCp and S_TiNb discs do not show an impact on the proliferation and viability of SaOs-2 cells compared to polystyrene surfaces, whereas a significant decrease in THP-1 cells’ viability and metabolic activity was observed in the presence of S_TiNb discs compared to the control group. However, no significant changes were found neeither at the metabolic activity nor at the transcriptomic level of THP-1 monocytes exposed to KNbO3 salt, suggesting that niobium has no effect on the immune system. Overall, these data imply a possible toxicity of S_TiNb discs toward THP-1 cells, which may not be directly related to niobium but perhaps to the manufacturing process of titanium- niobium alloy. Thus, this limitation must be overcome to make titanium alloy an excellent material for medical applications.

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“…However, the release of potentially harmful metal ions and their accumulation in body organs is of great concern, as vanadium is known for its cytotoxic effects, which can suppress cell growth and induce oxidative stress [10,11]. Therefore, Ti6Al7Nb alloy that contains less toxic, non-harmful Nb and meets the requirements for orthopaedic applications has been recently used [12][13][14]. These requirements include good biocompatibility, mechanical strength, stiffness, durability, corrosion resistance, and properties important for load-bearing applications (low elastic modulus and good fatigue resistance) [6,15,16].…”

Section: Introductionmentioning

confidence: 99%

Titanium Implant Alloy Modified by Electrochemically Deposited Functional Bioactive Calcium Phosphate Coatings

et al. 2023

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Calcium phosphate-based (CaP) bioceramic materials are widely used in the field of bone regeneration, both in orthopaedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The formation of CaP coatings on high-strength implant materials such as titanium alloys combines the superior mechanical properties of metals with the osteoconductive properties of CaP materials. In this work, the electrochemically assisted deposition of CaP coatings on the titanium alloy, TiAlNb, which is commonly used commercially as an implant material in orthopaedic devices, was examined. The barrier properties (electronic properties) of unmodified and CaP-modified titanium alloy were tested in situ in a simulated physiological solution, Hanks’ solution, under in vitro conditions of real implant applications using electrochemical impedance spectroscopy (EIS). The morphology and microstructure of the obtained CaP deposit were characterised by scanning electron microscopy (SEM) and chemical composition was assessed by energy dispersive X-ray spectroscopy (EDS) and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). The aim was to investigate the effect of calcium phosphate CaP coating on the corrosion resistance of the titanium TiAlNb alloy and to understand better the deposition process in the production of bioactive functional coatings on metallic implant materials.

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Comparison of osseointegration of Ti–Al6V4 and Ti–Al6Nb7 implants: An experimental study

Cited by 7 publications

References 17 publications

Biocompatibility of ZrO2 vs. Y-TZP Alloys: Influence of Their Composition and Surface Topography

Biocompatibility of ZrO2 vs. Y-TZP Alloys: Influence of Their Composition and Surface Topography

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

Titanium Implant Alloy Modified by Electrochemically Deposited Functional Bioactive Calcium Phosphate Coatings

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