Fabrication and characterization of zein-alginate oligosaccharide complex nanoparticles as delivery vehicles of curcumin

Jiang, Fangyuan; Yang, Lianlian; Wang, Songyan; Ying, Xiaoguo; Ling, Junhong; Ouyang, Xiaolong

doi:10.1016/j.molliq.2021.116937

Cited by 72 publications

(39 citation statements)

References 42 publications

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“…After 7,8-DHF encapsulation, no distinctive endothermic peaks of 7,8-DHF in DHF-zein, DHF-zein/LF, DHF-zein/LF 10K, DHF-zein/LF 40K, and DHF-zein/LF 70K were discovered, which suggested that 7,8-DHF changed from the crystalline state to the amorphous state. Some similar observations have been reported about curcumin ( 42 ) and β-carotene ( 43 ). Besides, the endothermic peak of DHF-zein was decreased from 71.12 to 68.57°C compared with bare zein nanoparticles ( Figure 5B ), the decrease in melting temperatures might be attributed to intermolecular interactions between 7,8-DHF and zein.…”

Section: Resultssupporting

confidence: 85%

Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone

et al. 2022

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In this work, the lactoferrin (LF) was glycosylated by dextran (molecular weight 10, 40, and 70 kDa, LF 10K, LF 40K, and LF 70K) via Maillard reaction as a stabilizer to establish zein/glycosylated LF nanoparticles and encapsulate 7,8-dihydroxyflavone (7,8-DHF). Three zein/glycosylated LF nanoparticles (79.27–87.24 nm) with low turbidity (<0.220) and polydispersity index (PDI) (<0.230) were successfully established by hydrophobic interactions and hydrogen bonding. Compared with zein/LF nanoparticles, zein/glycosylated LF nanoparticles further increased stability to ionic strength (0–500 mM NaCl) at low pH conditions. Zein/glycosylated LF nanoparticles had nanoscale spherical shape and glycosylated LF changed surface morphology of zein nanoparticles. Besides, encapsulated 7,8-DHF exhibited an amorphous state inside zein/glycosylated LF nanoparticles. Most importantly, zein/glycosylated LF nanoparticles had good water redispersibility, high encapsulation efficiency (above 98.50%), favorable storage stability, and bioaccessibility for 7,8-DHF, particularly LF 40K. Collectively, the above research provides a theoretical reference for the application of zein-based delivery systems.

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Section: Resultssupporting

confidence: 85%

Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone

et al. 2022

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“…The lack of endothermic peaks verified that 7,8-DHF was defined as an amorphous form rather than a crystalline form. Similar literature has reported in recent study on curcumin [47] and hyperoside [48]. In addition, the endothermic peak of DHF-S/Z nanoparticles was increased from 60.33 • C to 64.66 • C compared to S/Z.…”

Section: Spectrumsupporting

confidence: 89%

Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose

Chen

Peng

Wang

et al. 2021

Foods

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In this study, two polysaccharides [sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)] were selected to establish zein/sophorolipid/ALG (ALG/S/Z) and zein/sophorolipid/ALG (CMC/S/Z) nanoparticles to encapsulate 7,8-dihydroxyflavone (7,8-DHF), respectively. The results showed that polysaccharide types significantly affected performance of ternary nanoparticles, including CMC/S/Z possessed lower polydispersity index, particle size and turbidity, but higher zeta potential, encapsulation efficiency and loading capacity compared to ALG/S/Z. Compared to zein/sophorolipid nanoparticles (S/Z), both ALG/S/Z and CMC/S/Z had better stability against low pH (pH 3~4) and high ionic strengths (150~200 mM NaCl). Hydrophobic effects, electrostatic interactions and hydrogen bonding were confirmed in ternary nanoparticles fabrication via Fourier-transform infrared spectroscopy. Circular dichroism revealed that CMC and ALG had no evident impact on secondary structure of zein in S/Z, but changed surface morphology of S/Z as observed by scanning electron microscope. Encapsulated 7,8-DHF exhibited an amorphous state in ternary nanoparticles as detected by X-ray diffraction and differential scanning calorimetry. Furthermore, compared to S/Z, ALG/S/Z, and CMC/S/Z remarkably improved the storage stability and bioaccessibility of 7,8-DHF. CMC/S/Z possessed a greater storage stability for 7,8-DHF, however, ALG/S/Z exhibited a better in vitro bioaccessibility of 7,8-DHF. This research provides a theoretical reference for zein-based delivery system application.

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“…Unlike alginate, which is easier to form hydrogels and gel beads due to the remarkable gelation, AOs are more suitable for the development of nanoscale delivery systems (e.g., nanoparticles and nanocapsules) due to its lower viscosity and better solubility. For example, Jiang et al (2021) successfully developed zein-AOs nanoparticles as delivery carriers of curcumin through simple antisolvent precipitation method (Jiang et al, 2021). However, due to the fact that the production of AOs has not yet been industrialized, it is imperative to conduct in-depth research on developing more effective manufacturing technology to ultimately improve the productivity and yield of AOs.…”

Section: Alginate Oligosaccharide-based Delivery Systemmentioning

confidence: 99%

Alginate‐based delivery systems for food bioactive ingredients: An overview of recent advances and future trends

Wei

Xue

2021

Comp Rev Food Sci Food Safe

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Due to its advantagessuch as ionic crosslinking, pH responsiveness, excellent biocompatibility, biodegradability and low price, alginate has become one of the most important natural polysaccharides extensively used in constructing desired delivery systems for food bioactive ingredients. In this review, the fundamental knowledge of alginate as a building block for construction of nutraceutical delivery systems is introduced. Then, various types of alginate-based nutraceutical delivery systems are classified and summarized. Furthermore, the future trends of alginate-based delivery systems are highlighted. Currently, alginate-based delivery systems include hydrogel, emulsion, emulsion-filled alginate hydrogel, nanoparticle, microparticle, core-shell particle, liposome, edible film, and aerogel. Although alginate has been widely used in the fabrication of food bioactive ingredient delivery systems, further efforts and improvements are still needed. For this purpose, the future perspectives of alginate-based delivery systems are discussed. The feasible research trends of alginate-based delivery systems include the development of novel large-scale commercial preparation technology, multifunctional delivery system based on alginate, alginate oligosaccharide-based delivery system and alginate-based oleogel. Overall, the objective of this review is to provide useful guidance for rational design and application of alginate-based nutraceutical delivery systems in the future.

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Fabrication and characterization of zein-alginate oligosaccharide complex nanoparticles as delivery vehicles of curcumin

Cited by 72 publications

References 42 publications

Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone

Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone

Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose

Alginate‐based delivery systems for food bioactive ingredients: An overview of recent advances and future trends

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