Fabrication and characterization of thermo-sensitive magnetic polymer composite nanoparticles

Wu, Fengqin; Li, Qinhua; Zhang, Xiaojuan; Liu, Li; Wu, Shuai; Sun, Danping; Li, Fengsheng; Jiang, Wei

doi:10.1016/j.jmmm.2011.11.032

Cited by 13 publications

(7 citation statements)

References 31 publications

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“…For preparation of magnetic poly (St‐AMPS) adsorbent, hydrophobic magnetite nanoparticles coated with oleic acid were firstly prepared through the co‐precipitation method . In the three‐neck flask, FeCl 3 .6H 2 O (9.21 g) and FeSO 4 .7H 2 O (6.168 g) were mixed and dissolved in 90 ml distilled water with vigorous mechanically stirring under N 2 atmosphere.…”

Section: Methodsmentioning

confidence: 99%

“…[51] In the three-neck flask, FeCl 3 .6H 2 O (9.21 g) and FeSO 4 .7H 2 O (6.168 g) were mixed and dissolved in 90 ml distilled water with vigorous mechanically stirring under N 2 atmosphere. [51] In the three-neck flask, FeCl 3 .6H 2 O (9.21 g) and FeSO 4 .7H 2 O (6.168 g) were mixed and dissolved in 90 ml distilled water with vigorous mechanically stirring under N 2 atmosphere.…”

Section: Synthesis Procedures Of Adsorbentmentioning

confidence: 99%

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Preparation of magnetic nanoparticles functionalized with poly (styrene‐2‐acrylamido‐2‐methyl propanesulfonic acid) as novel adsorbents for removal of pharmaceuticals from aqueous solutions

Hayasi

Saadatjoo

2017

Adv Polym Technol

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This work describes the removal of three pharmaceuticals, namely ceftriaxone sodium (CFX), diclofenac sodium (DCF) and atenolol (ATN) from water using magnetic poly (styrene-2-acrylamido-2-methyl propanesulfonic acid) (St-AMPS) adsorbent. This adsorbent was characterized by several techniques such as FTIR, TEM, TGA, VSM and DLS. Three kinetic models, pseudo-first-order, pseudo-secondorder and intra-particle diffusion models were used to study the adsorption kinetics.The results showed that the adsorption kinetics of pharmaceuticals onto magnetic poly (St-AMPS) adsorbent followed the pseudo-second-order model and were relatively rapid. In addition, it was found that the intra-particle diffusion was not the sole rate-controlling step and the adsorption of pharmaceuticals onto adsorbent occurred via two steps adsorption process. The experimental data were fitted with three isotherm models including Freundlich, Langmuir and Dubinin-Radushkevich (D-R). It was found that the adsorption of pharmaceuticals onto magnetic poly (St-AMPS) nanoparticles was the best described by the Langmuir model. Maximum adsorption capacities of 150.602, 47.824 and 119.904 mg/g were obtained for DCF, ATN and CFX, respectively. Also the obtained free energy from D-R isotherm (6.19, 4.93 and 6.45 kJ/mol for DCF, ATN and CFX respectively) indicated that the adsorption process was a physiosorption. Magnetic poly (St-AMPS) adsorbent could be recycled for removal of CFX, DCF and ATN by alkaline aqueous solution (pH 8). Therefore, this adsorbent can act as a promising adsorbent for water treatment processes. K E Y W O R D Sadsorption, magnetic separation, pharmaceutical, poly (styrene-2-acrylamido-2-methyl propanesulfonic acid), regeneration

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Section: Methodsmentioning

confidence: 99%

Section: Synthesis Procedures Of Adsorbentmentioning

confidence: 99%

Preparation of magnetic nanoparticles functionalized with poly (styrene‐2‐acrylamido‐2‐methyl propanesulfonic acid) as novel adsorbents for removal of pharmaceuticals from aqueous solutions

Hayasi

Saadatjoo

2017

Adv Polym Technol

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“…The possible reason is that the cross-linker affects the interaction among functional groups which make the polymer thermo-sensitive. 28 Therefore, the LCST transfers to a higher temperature. Through the size changing, Fe 3 O 4 /ZnS@PNIPAM can be used as a drug carrier to realize the absorption and releasing of drugs controllably (Fig.…”

Section: Thermo-sensitive Propertymentioning

confidence: 99%

Synthesis and Evaluation of Thermo-Sensitive, Magnetic Fluorescent Nanocomposite as Trifunctional Drug Delivery Carrier

Jiang¹,

Chen²,

Wu³

et al. 2016

j nanosci nanotechnol

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The thermo-sensitive magnetic fluorescent trifunctional nanocomposite (Fe₃O₄/ZnS@PNIPAM) has been synthesized via a facile route. The obtained biocompatible nanocomposite was composed of monodisperse heterostructural Fe₃O₄/ZnS core and a thermo-sensitive poly(N-isopropyl acrylamide) (PNIPAM) shell. Fe₃O₄/ZnS acted as magnetic response and fluorescence luminous body, PNIPAM acted as drug loaded platform which can adsorb and release drug controllably. Fe₃O₄/ZnS@PNIPAM was characterized and all of the results showed that it had excellent magnetic response, photostability and thermo-sensitivity. Moreover, the drug release studies in vitro showed that the release rate increased with increasing temperature. MTT assays in model HepG2 cells demonstrated that Fe₃O₄/ZnS@PNIPAM was practically non-toxic. Thus, our results revealed that Fe₃O₄/ZnS@PNIPAM would be used in biomedical fields such as targeted drug delivery, as well as cancer diagnosis and treatment in the nearly future.

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“…Since the surface features can be highly altered by selecting different functional monomers, surface functionalization by grafting of the polymer is one of the most effective methods available for preparing polymer‐coated NPs. Based on broad application of Fe 3 O 4 NPs coated with thermo‐sensitive polymers in the fields of biotechnology and medicine, these structures have attracted much attention recently (Chou, Lai, Shih, Tsai, & Lue, ; Jain et al, ; Jia, Su, Wong, Chen, & Dominic Chan, ; Wu et al, ). Thermo‐sensitive coated Fe 3 O 4 NPs can potentially be controlled and used in targeted drug release systems.…”

Section: Introductionmentioning

confidence: 99%

Employment of modified Fe₃O₄ nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples

Naghibi

Sahebi

2017

Biomedical Chromatography

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Cefexime is a useful antibiotic that can be prescribed to treat bacterial infections. Nanoparticles have been widely marketed as a universal solution among scientists. Many studies have been performed to modify nanoparticles to make them functional as extraction and pre-concentration agents and drug carriers. Temperature-sensitive polymers belong to a group of substances that undergo a major change in their physical features in response to temperature. Recently developed polymers can be used in many different areas, including modification of nanoparticles. In order to modify this nanoparticle, grafting copolymerization of Fe O nanoparticles was performed using poly (N-vinylcaprolactam) and 3-allyloxy-1,2-propanediol. The optimum conditions for pre-concentration of cefexime were studied. Under these optimum conditions, extraction recovery of biological samples in the range of 71-89% was obtained. The limit of detection and precision of proposed method were 4.5 × 10 μg mL and <4.11% (relative standard deviation), respectively. Based on the results from analysis of cefexime, in biological samples using the proposed method, the ability of this method to extract and pre-concentrate cefexime was confirmed. Also, satisfactory results from an in vitro study on drug release in simulated intestine media were obtained.

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Fabrication and characterization of thermo-sensitive magnetic polymer composite nanoparticles

Cited by 13 publications

References 31 publications

Preparation of magnetic nanoparticles functionalized with poly (styrene‐2‐acrylamido‐2‐methyl propanesulfonic acid) as novel adsorbents for removal of pharmaceuticals from aqueous solutions

Preparation of magnetic nanoparticles functionalized with poly (styrene‐2‐acrylamido‐2‐methyl propanesulfonic acid) as novel adsorbents for removal of pharmaceuticals from aqueous solutions

Synthesis and Evaluation of Thermo-Sensitive, Magnetic Fluorescent Nanocomposite as Trifunctional Drug Delivery Carrier

Employment of modified Fe₃O₄ nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples

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Fabrication and characterization of thermo-sensitive magnetic polymer composite nanoparticles

Cited by 13 publications

References 31 publications

Preparation of magnetic nanoparticles functionalized with poly (styrene‐2‐acrylamido‐2‐methyl propanesulfonic acid) as novel adsorbents for removal of pharmaceuticals from aqueous solutions

Preparation of magnetic nanoparticles functionalized with poly (styrene‐2‐acrylamido‐2‐methyl propanesulfonic acid) as novel adsorbents for removal of pharmaceuticals from aqueous solutions

Synthesis and Evaluation of Thermo-Sensitive, Magnetic Fluorescent Nanocomposite as Trifunctional Drug Delivery Carrier

Employment of modified Fe3O4 nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples

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Employment of modified Fe₃O₄ nanoparticles using thermo‐sensitive polymer for extraction and pre‐concentration of cefexime in biological samples