The thermo-sensitive magnetic fluorescent trifunctional nanocomposite (Fe₃O₄/ZnS@PNIPAM) has been synthesized via a facile route. The obtained biocompatible nanocomposite was composed of monodisperse heterostructural Fe₃O₄/ZnS core and a thermo-sensitive poly(N-isopropyl acrylamide) (PNIPAM) shell. Fe₃O₄/ZnS acted as magnetic response and fluorescence luminous body, PNIPAM acted as drug loaded platform which can adsorb and release drug controllably. Fe₃O₄/ZnS@PNIPAM was characterized and all of the results showed that it had excellent magnetic response, photostability and thermo-sensitivity. Moreover, the drug release studies in vitro showed that the release rate increased with increasing temperature. MTT assays in model HepG2 cells demonstrated that Fe₃O₄/ZnS@PNIPAM was practically non-toxic. Thus, our results revealed that Fe₃O₄/ZnS@PNIPAM would be used in biomedical fields such as targeted drug delivery, as well as cancer diagnosis and treatment in the nearly future.
Novel Fe3O4-CdSe nanocomposites were prepared by depositing semiconductor on monodisperse magnetic nanoparticles. First, monodisperse Fe3O4 nanoparticles were fabricated by a solvothermal process in which iron acetylacetonate (Fe(acac)3) was used as precursor, phenyl ether as reaction medium, oleic acid as surfactant and oleylamine (OAm) as both surfactant and reducing agent. Novel Fe3O4-CdSe heterostructures were prepared using 1-octadecene as high boiling solvent, cadmium oxide as Cd precursor, trioctyl phosphate (TOP)-Se as Se precursor, n-hexadecylamine (HDA) as surfactant, and stearic acid (SA) as growth promoter and nucleating agent. The structure and properties of the Fe3O4-CdSe nanocomposite were fully characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), UV-Vis spectrum, and photoluminescence (PL). CdSe nanoparticles were successfully attached to the surface of Fe3O4 and grew along the c-axis to form novel jujube pit-liked and nail-liked heterostructures with a width of 3.6 nm and length of 14.5 and 32.5 nm, 1088 LIU Li et al.: Facile Fabrication of Novel Magnetic and Fluorescent Fe3O4-CdSe NanocompositesNo.5 respectively. The novel nanocomposites were a combination of magnetite Fe3O4 and hexagonal CdSe rods, and exhibited strong fluorescent emission without obvious quenching and excellent superparamagnetic properties. Fluorescent absorption shifts to longer wavelength as the length of the CdSe rods increases. The saturation magnetization of Fe3O4 nanoparticles, jujube pit liked and nail liked Fe3O4-CdSe nanocomposites were 57.80, 40.76, and 31.10 emu•g -1 , respectively.
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