Fabrication and Characterization of PCL/HA Filament as a 3D Printing Material Using Thermal Extrusion Technology for Bone Tissue Engineering

Wang, Fengze; Tankus, Esma Bahar; Santarella, Francesco; Rohr, Nadja; Sharma, Neha; Märtin, Sabrina; Michalscheck, Mirja; Maintz, Michaela; Cao, Shuaishuai; Thieringer, Florian M.

doi:10.3390/polym14040669

Cited by 38 publications

(37 citation statements)

References 59 publications

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“…A large number of hydrogels based on natural polymers such as alginates (ALG), hyaluronic acid (HA), collagens, gelatins, chitosan, and cellulose have been used as printable materials in the treatment of wound healing [ 72 , 82 , 95 – 105 ]. To facilitate and improve the resolution of 3D printing objects, synthetic biopolymers can be incorporated together with natural biopolymers and APIs [ 88 , 106 – 113 ]. Table II summarizes the characteristics of the biopolymers and characteristics of the inks most commonly used in bioprinting/3D printing.…”

Section: An Overview Of Additive Manufacturingmentioning

confidence: 99%

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3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing

Uchida

Bruschi

2023

AAPS PharmSciTech

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Wound healing is a dynamic process which involves stages of hemostasis, inflammation, proliferation and remodeling. Any error in this process results in abnormal wound healing, generating financial burdens for health systems and even affecting the physical and mental health of the patient. Traditional dressings do not meet the complexities of ideal treatment in all types of wounds. For this reason, in the last decades, different materials for drug delivery and for the treatment of wounds have been proposed reaching novel level of standards, such as 3D printing techniques. The use of natural or synthetic polymers, and the correct design of these printed products loaded with cells and/or combined with active compounds, can generate an effective system for the treatment of wounds, improving the healing process and generating customized dressings according to the patient needs. This manuscript provides a comprehensive review of different types of 3D printing techniques, as well as its use in wound healing and its different stages, including the advantages and limitations of additive manufacturing and future perspectives. Graphical abstract

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Section: An Overview Of Additive Manufacturingmentioning

confidence: 99%

“…It allows fabrication of complex biomimetic and patient-specific structures. [ 106 , 107 ] Polyethylene glycol (PEG) PEG is a synthetic material that has been widely used due to its hydrophilicity and biocompatibility. Its ability to be chemically adapted makes it a good material for 3D printing.…”

Section: An Overview Of Additive Manufacturingmentioning

confidence: 99%

3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing

Uchida

Bruschi

2023

AAPS PharmSciTech

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“…PCL/HA composites have also been extensively explored. Wang et al 117 prepared PCL/ HA implants for craniomaxillofacial reconstruction through DIW. The mechanical and biological properties of the composite implant were improved with the increase of HA content (0%−25% w/w).…”

Section: Additive Manufacturing Of Bioceramic/polymermentioning

confidence: 99%

Additive Manufacturing of Bioceramic Implants for Restoration Bone Engineering: Technologies, Advances, and Future Perspectives

Zhou

Su²,

et al. 2023

ACS Biomater. Sci. Eng.

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Treating bone defects is highly challenging because they do not heal on their own inside the patients, so implants are needed to assist in the reconstruction of the bone. Bioceramic implants based on additive manufacturing (AM) are currently emerging as promising treatment options for restoration bone engineering. On the one hand, additively manufactured bioceramic implants have excellent mechanical properties and biocompatibility, which are suitable for bone regeneration. On the other hand, the designable structure and adjustable pores of additively manufactured bioceramic implants allow them to promote suitable cell growth and tissue climbing. Herein, this review unfolds to introduce several frequently employed AM technologies for bioceramic implants. After that, advances in commonly used additively manufactured bioceramic implants, including bioinert ceramic implants, bioactive ceramic implants, and bioceramic/organic composite implants, are categorized and summarized. Finally, the future perspectives of additively manufactured bioceramic implants, in terms of mechanical performance improvement, innovative structural design, biological property enhancement, and other functionalization approaches, are proposed and forecasted. This review is believed to provide some fundamental understanding and cutting-edge knowledge for the additive manufacturing of bioceramic implants for restoration bone engineering.

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“…A number of studies have attempted to improve the biomaterial properties of PCL-based scaffolds by conducting research on PCL-based composites [ 43 , 44 , 45 , 46 ]. PCL showed the slowest degradation time among polyester group polymers [ 15 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

PCL and DMSO2 Composites for Bio-Scaffold Materials

et al. 2023

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Polycaprolactone (PCL) has been one of the most popular biomaterials in tissue engineering due to its relatively low melting temperature, excellent thermal stability, and cost-effectiveness. However, its low cell attraction, low elastic modulus, and long-term degradation time have limited its application in a wide range of scaffold studies. Dimethyl sulfone (DMSO2) is a stable and non-hazardous organosulfur compound with low viscosity and high surface tension. PCL and DMSO2 composites may overcome the limitations of PCL as a biomaterial and tailor the properties of biocomposites. In this study, PCL and DMSO2 composites were investigated as a new bio-scaffold material to increase hydrophilicity and mechanical properties and tailor degradation properties in vitro. PCL and DMSO2 were physically mixed with 10, 20, and 30 wt% of DMSO2 to evaluate thermal, hydrophilicity, mechanical, and degradation properties of the composites. The water contact angle of the composites for hydrophilicity decreased by 15.5% compared to pure PCL. The experimental results showed that the mechanical and degradation properties of PCL and DMSO2 were better than those of pure PCL, and the properties can be tuned by regulating DMSO2 concentration in the PCL matrix. The elastic modulus of the composite with 30 wt% of DMSO2 showed 532 MPa, and its degradation time was 18 times faster than that of PCL.

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Fabrication and Characterization of PCL/HA Filament as a 3D Printing Material Using Thermal Extrusion Technology for Bone Tissue Engineering

Cited by 38 publications

References 59 publications

3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing

3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing

Additive Manufacturing of Bioceramic Implants for Restoration Bone Engineering: Technologies, Advances, and Future Perspectives

PCL and DMSO2 Composites for Bio-Scaffold Materials

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