Fabrication and characterization of monodisperse PLGA–alginate core–shell microspheres with monodisperse size and homogeneous shells for controlled drug release

Wu, Jun; Kong, Tiantian; Yeung, Kelvin Wai Kwok; Shum, Ho Cheung; Cheung, Kenneth Man Chee; Wang, Liqiu; To, Michael

doi:10.1016/j.actbio.2013.03.022

Cited by 155 publications

(97 citation statements)

References 43 publications

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“…Even though this initial burst release might be not very harmful to the users, it might cause API concentration beyond the therapeutic window and reduce the amount of API available for contraception and the duration of release (71)(72)(73). Among the methods studied for minimizing the initial burst release, coating or core/shell structure is one of the most straightforward strategies (74,75). This additional layer of shell could be created by a dipping, mixing or emulsion process (42).…”

Section: Microsphere Fabrication and Sterilization Processesmentioning

confidence: 97%

Long-Acting Injectable Hormonal Dosage Forms for Contraception

Janagam

Mandrell

et al. 2015

Pharm Res

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Although great efforts have been made to develop long-acting injectable hormonal contraceptives for more than four decades, few long-acting injectable contraceptives have reached the pharmaceutical market or even entered clinical trials. On the other hand, in clinical practice there is an urgent need for injectable long-acting reversible contraceptives which can provide contraceptive protection for more than 3 months after one single injection. Availability of such products will offer great flexibility to women and resolve certain continuation issues currently occurring in clinics. Herein, we reviewed the strategies exploited in the past to develop injectable hormonal contraceptive dosages including drug microcrystal suspensions, drug-loaded microsphere suspensions and in situ forming depot systems for long-term contraception and discussed the potential solutions for remaining issues met in the previous development.

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Section: Microsphere Fabrication and Sterilization Processesmentioning

confidence: 97%

Long-Acting Injectable Hormonal Dosage Forms for Contraception

Janagam

Mandrell

et al. 2015

Pharm Res

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“…[205][206][207][208] They combine the advantages of both adherent and suspension cultures, and are suitable for large-scale cultivation of different cells. However, traditional barcode particles are usually small, several microns in diameter, and thus they cannot be employed for cell culture.…”

Section: Cell Culturementioning

confidence: 99%

Microfluidic Synthesis of Barcode Particles for Multiplex Assays

Zhao

Cheng

Shang

et al. 2014

Small

185

139

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The increasing use of high-throughput assays in biomedical applications, including drug discovery and clinical diagnostics, demands effective strategies for multiplexing. One promising strategy is the use of barcode particles that encode information about their specific compositions and enable simple identification. Various encoding mechanisms, including spectroscopic, graphical, electronic, and physical encoding, have been proposed for the provision of sufficient identification codes for the barcode particles. These particles are synthesized in various ways. Microfluidics is an effective approach that has created exciting avenues of scientific research in barcode particle synthesis. The resultant particles have found important application in the detection of multiple biological species as they have properties of high flexibility, fast reaction times, less reagent consumption, and good repeatability. In this paper, research progress in the microfluidic synthesis of barcode particles for multiplex assays is discussed. After introducing the general developing strategies of the barcode particles, the focus is on studies of microfluidics, including their design, fabrication, and application in the generation of barcode particles. Applications of the achieved barcode particles in multiplex assays will be described and emphasized. The prospects for future development of these barcode particles are also presented.

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“…The suitability of the methodology was tested for the poorly water-soluble poly(DL-lactide-co-glycolide) (PLGA) and the antimicrobial agent ciprofloxacin dispersed in the organic solvent dioxane. PLGA has been widely used for many years for the encapsulation and controlled release of drugs from several dosage forms, including microspheres, because of its biocompatibility and slow biodegradability via hydrolytic processes [16,[24][25][26][27]. PLGA particles are commonly prepared by applying the solvent evaporation and solvent extraction technique [14,28,29].…”

Section: Introductionmentioning

confidence: 99%