Bioinspired superamphiphobic surfaces as a tool for polymer- and solvent-independent preparation of drug-loaded spherical particles

Rial-Hermida, M. Isabel; Oliveira, Nuno M.; Concheiro, Angel; Mano, João F.

doi:10.1016/j.actbio.2014.06.009

Cited by 25 publications

(25 citation statements)

References 42 publications

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“…In our approach, the viscous Eri silk/BMIMAc solutions were put under vacuum, resulting in the formation of a gel, which was molded into silicone molds placed over super-amphiphobic surfaces. These surfaces are characterized by high water and some organic solvents repellence due to its surface roughness and low surface energy [26,27]. These surface characteristics avoided the flow out of the Eri silk/BMIMAc solutions from the cylindrical molds during the gelation process.…”

Section: Resultsmentioning

confidence: 99%

“…The Eri silk fibroin sponges were prepared by dissolving the degummed fibers of S. ricini cocoons in BMIMAc at 90-95°C in a concentration of 10% (w/v). The system was kept under stirring for 6 h. After dissolution, the fiber/IL solutions were transferred to specific silicone molds, which were placed over superamphiphobic surfaces prepared as previously described [26,27] with minor changes. Briefly, the glass slides were held above the flame of a paraffin candle until reaching a homogeneous carbon layer on the glass surface.…”

Section: Preparation Of the Eri Silk/il Solutions Cross-linking Reacmentioning

confidence: 99%

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Fabrication and characterization of Eri silk fibers-based sponges for biomedical application

Silva

Oliveira

et al. 2016

Acta Biomaterialia

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This work addresses the preparation and characterization of non-mulberry cocoon-derived Eri silk sponges. The insolubility of cocoons-derived non-mulberry silkworms impairs their processability and applications in the healthcare field. We used a green approach with ionic liquids to overcome the lack solubility of such silk fibers. The formation of beta-sheet structures into Eri-based sponges was physically and chemically induced. The sponges were obtained by freeze-drying. The developed structures exhibited flexibility to adapt and recover their shapes upon application and subsequent removal of load, high swelling degree, ability to load an anti-inflammatory drug and to promote its sustained release. They promoted in vitro cellular adhesion, proliferation and extracellular matrix production of a chondrocyte-like cell line, opening up their potential application for biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Preparation Of the Eri Silk/il Solutions Cross-linking Reacmentioning

confidence: 99%

Fabrication and characterization of Eri silk fibers-based sponges for biomedical application

Silva

Oliveira

et al. 2016

Acta Biomaterialia

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“…A 5 ml droplet of the solution was placed on the prepared superamphiphobic plates. Then, the plates were left for air drying for 24 h and later the beads were collected for further investigation (Rial-Hermida et al, 2014).…”

Section: Preparation Of Vp-loaded Polymeric Beadsmentioning

confidence: 99%

“…The main concern about such technique is the restriction offered by the solvent type, as only pure water can be used as solvent. This hinders its application with hydrophobic polymers which could be of special interest in controlled release formulations (Rial-Hermida et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Instead, superamphiphobic surfaces that show high contact angles and low wettability for both water and organic oils (Manna et al, 2017) could be a more promising universal method in drug formulations as it doesn't offer any restrictions on the polymer type or the solvent used. Although several methods to fabricate superamphiphobic surfaces on different substrates were reported (Deng et al, 2012(Deng et al, , 2017Qing et al, 2017), only Rial-Hermida et al (2014) applied such surfaces in pharmaceutical formulations. They managed to prepare superamphiphobic surface using glass substrates to be used in the formulation of ciprofloxacin-loaded lactide/glycolide (PLGA) particles for sustained release formulation.…”

Section: Introductionmentioning

confidence: 99%

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Ultrahigh verapamil-loaded controlled release polymeric beads using superamphiphobic substrate: D-optimal statistical design, in vitro and in vivo performance

et al. 2018

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Controlled-release multiparticulate systems of hydrophilic drugs usually suffer from poor encapsulation and rapid-release rate. In the present study, ultra-high loaded controlled release polymeric beads containing verapamil hydrochloride (VP) as hydrophilic model drug were efficiently prepared using superamphiphobic substrates aiming to improve patient compliance by reducing dosing frequency. Superamphiphobic substrates were fabricated using clean aluminum sheets etched with ammonia solution and were treated with 1.5% (w/v) perfluorodecyltriethoxysilane (PFDTS) alcoholic solution. The effect of the main polymer type (lactide/glycolide (PLGA) 5004A, PLGA 5010, and polycaprolactone (PCL)), copolymer (Eudragit RS100) content together with the effect of drug load on encapsulation efficiency (EE%) and in vitro drug release was statistically studied and optimized via D-optimal statistical design. In vivo pharmacokinetic study was carried out to compare the optimized system relative to the market product (Isoptin). Results revealed that superamphiphobic substrates were successfully prepared showing a rough micro-sized hierarchical structured surface upon observing with scanning electron microscope and were confirmed by high contact angles of 151.60 ± 2.42 and 142.80°±05.23° for water and olive oil, respectively. The fabricated VP-loaded beads showed extremely high encapsulation efficiency exceeding 92.31% w/w. All the prepared systems exhibited a controlled release behavior with Q12 h ranging between 5.46 and 95.90%w/w. The optimized VP-loaded system composed of 150 mg (1.5% w/v) PCL without Eudragit RS100 together with 160 mg VP showed 2.7-folds mean residence time compared to the market product allowing once daily administration instead of three times per day.

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Marine‐origin Polysaccharides for Tissue Engineering and Regenerative Medicine

Reys

Silva

Oliveira

et al. 2020

Encyclopedia of Marine Biotechnology

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Bioinspired superamphiphobic surfaces as a tool for polymer- and solvent-independent preparation of drug-loaded spherical particles

Cited by 25 publications

References 42 publications

Fabrication and characterization of Eri silk fibers-based sponges for biomedical application

Fabrication and characterization of Eri silk fibers-based sponges for biomedical application

Ultrahigh verapamil-loaded controlled release polymeric beads using superamphiphobic substrate: D-optimal statistical design, in vitro and in vivo performance

Marine‐origin Polysaccharides for Tissue Engineering and Regenerative Medicine

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