Fabrication and Characterization of Biodegradable Poly(3-hydroxybutyrate) Composite Containing Bioglass

Abstract

Bacterially derived poly(3-hydroxybutyrate) (P(3HB)) has been used to produce composite films by incorporating Bioglass particles (<5 microm) in 5 and 20 wt % concentrations. P(3HB) was produced using a large scale fermentation technique. The polymer was extracted using the Soxhlet technique and was found to have similar thermal and structural properties to the commercially available P(3HB). The effects of adding Bioglass on the microstructure surface and thermal and mechanical properties were examined using differential scanning calorimetry, dynamic mechanical analysis (DMA), X-ray diffraction, surface interferometry, electron microscopy, and nanoindentation. The addition of increasing concentrations of Bioglass in the polymer matrix reduced the degree of crystallinity of the polymer as well as caused an increase in the glass transition temperature as determined by DMA. The presence of Bioglass particulates reduced the Young's modulus of the composite. The storage modulus and the loss modulus, however, increased with the addition of 20 wt % Bioglass. A short period (28 days) in vitro bioactivity study in simulated body fluid confirmed the bioactivity of the composites, demonstrated by the formation of hydroxyapatite crystals on the composites' surface.

Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds

“…The effect of the particle size of SG-B particles on the properties of PVA/SG-B scaffolds, which are being developed for tissue engineering applications [32]. The morphology of the prepared scaffolds is presented in (figure 2); in which we can observe that all the prepared scaffolds have wide range of interconnected pores including macro, micro and nanopores as it also confirmed by mercury porosimeter.…”

“…The co-existence of macropores and micropores is not only favorable for the ingrowth of cells and new tissue but also beneficial to the exchange of nutrients and metabolic waste [34]. The porosity percentage for the prepared scaffolds was determined by MIP and liquid displacement methods and there was no significant difference between the two methods as it is demonstrated in table (1) [32].…”

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

“…1), ester peak intensity reduced through the addition of bioglass and a new peak assigned to carboxylate was detected [26,28]. This is believed to be a result of partial immobilization of polymer chains by increasing the crosslinking density while polymer adsorbed onto the bioglass surface and the physical crosslinks formed [29].…”

Production of polyhydroxybutyrate and hydroxyapatite (PHB/HA) composites for use as biomaterial

“…Bone is formed close to the material and subsequently becomes highly organized, with up to 80% of the implant surface lying in direct apposition to new bone [7]. PHB-based biomaterials have also been related to be piezoelectric and promote bone growth in vivo [8,9].…”