Fabricating Water Dispersible Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications through Ligand Exchange and Direct Conjugation

Lam, Tina Poy Wing; Avti, Pramod K.; Pouliot, Philippe; Maafi, Foued; Tardif, Jean‐Claude; Rhéaume, Éric; Lesage, Frédéric; Kakkar, Ashok

doi:10.3390/nano6060100

Cited by 26 publications

(17 citation statements)

References 60 publications

(79 reference statements)

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“…However, there are several factors that strongly affect nanomaterials antioxidant activity for instance chemical composition, surface charge, particle size, and coating of the surface [ 6 , 26 , 27 , 28 , 29 ]. The surface coating could be biocompatible, nontoxic and allow targeted drug delivery [ 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents

et al. 2017

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In this research, we report the size-controlled synthesis and surface-functionalization of magnetite with the natural antioxidant gallic acid (GA) as a ligand, using in situ and post-synthesis methods. GA functionalization provided narrow size distribution, with an average particle size of 5 and 8 nm for in situ synthesis of gallic acid functionalized magnetite IONP@GA1 and IONP@GA2, respectively, which are ultra-small particles as compared to unfunctionalized magnetite (IONP) and post functionalized magnetite IONP@GA3 with average size of 10 and 11 nm respectively. All the IONPs@GA samples were found hydrophilic with stable aggregation state. Prior to commencement of experimental lab work, PASS software was used to predict the biological activities of GA and it is found that experimental antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and antimicrobial studies using well diffusion method are in good agreement with the simulated results. Furthermore, the half maximal inhibitory concentration (IC50) values of DPPH antioxidant assay revealed a 2–4 fold decrease as compared to unfunctionalized IONP. In addition to antioxidant activity, all the three IONP@GA proved outstanding antimicrobial activity while testing on different bacterial and fungal strains. The results collectively indicate the successful fabrication of novel antioxidant, antimicrobial IONP@GA composite, which are magnetically separable, efficient, and low cost, with potential applications in polymers, cosmetics, and biomedical and food industries.

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Section: Introductionmentioning

confidence: 99%

Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents

et al. 2017

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“…The different types of IO used for the NPs synthesis include Fe3O4 (magnetite), α-Fe2O3 (hematite or antiferromagnetic), c-Fe2O3 (maghemite, ferrimagnetic), FeO (wustite, anti-ferromagnetic), γ-Fe2O3 and β-Fe2O3. However, Fe3O4 and γ-Fe2O3 NPs are the favorable and most commonly used chemical forms that are specially designed for various biomedical applications such as imaging contrast agents for MRI, thermal therapeutic tools [25,26] and as cargo vehicles due to their features of improved biocompatibility and easy formulation [27][28][29][30]. These are structurally constituted, having nanocrystalline magnetite Fe3O4 or γ-Fe2O3 with a polymeric coating.…”

Section: Iron Oxide (Io)-npsmentioning

confidence: 99%

“…can be considered to modify the surface of IONPs, i.e., organic and inorganic coatings [27]. The organic biocompatible based coating approaches are by either using a ligand exchange mechanism or physical assemblage/encapsulation [28].…”

Section: Fig 2: Types Of Nps and Their Multifunctional Strategiesmentioning

confidence: 99%

Tailoring the Nanoparticles Surface for Efficient Cancer Therapeutics Delivery

et al. 2020

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Nanotechnology has tremendous advantages in many areas of scientific as well as clinical research. The development of nanoparticles (NPs) that can efficiently deliver drugs specifically to the cancer cells can help reduce normal cells toxicity and co-morbidities. Cancer can be treated by exploiting the unique physiochemical of the NPs, and modulating their surface modifications using ligands which further could be used as drug cargo vehicles. To enhance biocompatibility and drug delivery towards the target site, various modifications can be included to modify the surface of the NPs, such as carbohydrates, dendrimers, DNA, RNA, siRNA, drugs, and other ligands. These ligand-coated NPs have potential applications in the field of biomedical research, including diagnosis, contrast agents for molecular and clinical imaging (Magnetic Resonance Imaging (MRI), Computed tomography (CT), positron emission tomography (PET)), as cargo vehicles for drugs, increasing the blood circulation half-life, and blood detoxification. Further, the conjugation of anti-cancer drugs to the NPs can be efficiently used to target the cancer disease. This review highlights some of the features and surface modification strategies of the NPs, such as an iron oxide (IO), liposomes (LP)-based NPs, and polymer-based NPs, which show their effectiveness as cargo agents for cancer therapeutics.

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“…Good number of nanomaterials like metallic, organic and inorganic nanoparticles, liposomes, polyplexes, quantum dots, carbon nanomaterials like carbon nanotubes, fullerene, graphene, etc, have been considered in the investigation related to biological, biomedical fields specifically also in the field of stem cell research [3,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Synthetic materials like polylactides-co-glycolide (PGLA), polycaprolactone and naturally occurring materials like collagen, chitosan etc, have been involved in biological and biomedical research [23]. Some of the most common aspects that have been considered under stem cell research include non-evasive tracing of stem cells, transplanted progenitor cells, intracellular delivery of DNA, RNA interference molecules like proteins, peptides, genes, and small drugs either during stem cells differentiation or to investigate cellular biochemical processes [39].…”

Section: Nanomaterials In the Service Of Biological And Biomedical Fimentioning

confidence: 99%

Review-Influence of Nanomaterials on Cellular Stress, and Cellular Behavior

Lahir¹

2018

(ACT)

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The cellular responses to stress are a complex phenomenon. These have faced varied impacts of the advancements in biomolecular, cellular and biomedical fields that have taken place from time to time. Nanotechnology and nanomaterials have played their major roles in these advanced achievements. The interactions between cells and the various nanomaterials are obvious due to fabricated and/or engineered nanomaterials that are designed with special features to attain specific set targets. These nanomaterials are utilized in varied modes such as drug carriers, remedial agents of environmental aspects, biotechnological and biomedical processes, implants, biosensors etc. The implications of these wonder materials in any biosystems, industrial processes and products etc ensure their interactions with cells. Nanomaterials are also capable to induce cellular stress in biosystem as they are the components of the products used in daily life. There are numerous biomolecules and the cellular processes that are involved in intra and intercellular communications. The cellular communication is the prime functional aspect for cell survival. The interaction between the cells and the nanomaterials are likely to influence this cellular communications and other cellular processes. These features in all probabilities affect cellular responses. Cellular responses are protective and/ or rendering the affected cells prone to necrosis or cellular death. Various nanomaterials with different reactive affinities are bound to influence the cellular responses with respect to the stress. This reflects on the needs to evaluate and understand the mechanism involved during the process of cellular stress and the related behavior.

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Fabricating Water Dispersible Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications through Ligand Exchange and Direct Conjugation

Cited by 26 publications

References 60 publications

Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents

Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents

Tailoring the Nanoparticles Surface for Efficient Cancer Therapeutics Delivery

Review-Influence of Nanomaterials on Cellular Stress, and Cellular Behavior

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