Extranodal marginal zone lymphoma of the uterine corpus

Wright, Tanwen; Rule, Simon; Liu, Hongxiang; Du, Ming‐Qing; Smith, Mark E.

doi:10.3109/10428194.2012.660750

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…In contrast to typical FL, in which CREBBP and KMT2D mutations occur in ;80% of cases, 6,7,9,23 recurrent mutations in these genes were not identified within our PTNFL cohort. We also show that CREBBP mutations occur at high frequency in typical FL with limited-stage presentation, just as observed in advanced stage FL.…”

Section: Discussioncontrasting

confidence: 58%

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Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations

Louissaint

Schafernak

Geyer

et al. 2016

Blood

126

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Section: Discussioncontrasting

confidence: 58%

“…In contrast to the well-characterized landscape of typical FL, [3][4][5][6][7][8][9][10][11][12][13][14][15][16] the molecular genetic features of PTNFL are essentially undefined. Therefore, we performed comprehensive mutation analysis and copy number variant analysis on PTNFLs from children and adults to address this problem.…”

Section: Introductionmentioning

confidence: 99%

Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations

Louissaint

Schafernak

Geyer

et al. 2016

Blood

126

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“…In addition, the majority of primary uterus lymphomas are high-grade subtypes, such as diffuse large B-cell lymphoma (DLBCL) (7), whilst the occurrence of EMZL of the uterus is rare, with only 17 previously reported cases in the English literature (8–21), and their cytogenetic/genetic characteristics remain unknown. The present study reports a patient with primary uterine cervical EMZL with the concomitant copy number gains of MALT1 and B-cell lymphoma 2 ( BCL2 ) genes, which are located at chromosome 18q21.…”

Section: Introductionmentioning

confidence: 99%

Extranodal marginal zone lymphoma of the uterine cervix with concomitant copy number gains of the MALT1 and BCL2 genes: A case report

et al. 2017

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Extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT) of the uterus is rare, and the etiology, pathophysiology and cytogenetic features remain unknown at present. The present study reports a case of a 71-year-old female with EMZL of the uterine cervix that was 80 mm in diameter and invaded directly into the rectal serosa. Complete remission was successfully induced by 6 courses of immunochemotherapy with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisolone. Although the metaphase spread of the tumor cells was unavailable for whole cytogenetic analysis, fluorescence in situ hybridization (FISH) detected triple signals for MALT1 and B-cell lymphoma 2, located at chromosome 18q21, and the centromere of chromosome 18, which was suggestive of trisomy 18, and in combination with previous studies, suggested a possible association between trisomy 18 and the large tumor at initial presentation in the present patient. In addition, FISH examination detected immunoglobulin heavy chain gene rearrangement, although the translocation partner was unconfirmed. A total of 18 previously-studied patients with EMZL of the uterus, including that of the present study, were reviewed with respect to their clinical features and treatment and cytogenetic abnormality. In the evaluation of the English scientific literature, this is the first reported patient with EMZL of the uterus with partly determined cytogenetic abnormalities.

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“…1 Marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) of the uterus is extremely rare, with only seven cases reported in the literature. [2][3][4][5][6][7][8] We report a rare case of an extranodal marginal zone B cell lymphoma arising from the MALT tissue of the endometrium.…”

mentioning

confidence: 99%

“…[2][3][4][5][6][7][8] The mean age of presentation was 65 years (range 43-81). Three presented with abnormal vaginal bleeding, one with pelvic pressure effect causing dysuria and three were incidental findings.…”

mentioning

confidence: 99%

Primary extranodal marginal zone B cell lymphoma of the uterus: a case study and review of the literature

et al. 2013

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Extranodal marginal zone lymphoma of the uterine corpus

Cited by 6 publications

References 8 publications

Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations

Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations

Extranodal marginal zone lymphoma of the uterine cervix with concomitant copy number gains of the MALT1 and BCL2 genes: A case report

Primary extranodal marginal zone B cell lymphoma of the uterus: a case study and review of the literature

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