Primary extranodal marginal zone B cell lymphoma of the uterus: a case study and review of the literature

Merritt, Anita J.; Shenjere, Patrick; Menasce, Lia P; Reid, Fiona; Diss, Tim C.; McVey, Rhona J; Byers, Richard

doi:10.1136/jclinpath-2013-202059

Cited by 8 publications

(8 citation statements)

References 6 publications

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“…Most cases include postmenopausal women with a bleeding issue as the dominant symptom whose diagnosis is based on histopathological examination of the material obtained by curettage. In a minority of cases, the disease was severe and diagnosis was established after the histopathological examination of the uterus after surgery for other reasons (uterovaginal prolapse) [1,5,10,11]. Our patient was 45 years old and the only symptom was menometrorrhagia she had had for 10 months.…”

Section: Discussionmentioning

confidence: 96%

Primary endometrial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type

et al. 2018

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Introduction Primary lymphomas of the female genital system are rare and represent about 2% of extranodal lymphomas and about 0.5% of malignant gynecological diseases, which occur in only 0.5% of cases in the cervix and uterine body. Mucosa-associated lymphoid tissue (MALT) lymphoma represents a rare variant of the primary genital lymphoma. Case outline This paper presents the case of a 45-year-old patient who visited a gynecologist due to abnormal menstrual bleeding within the previous three years and bloody excrement between menstrual bleedings. The ultrasound examination raised doubts about endometrial polyps, thus the fractional exploratory curettage was performed. Histologically, a dense infiltration of stromal endometrium was demonstrated in the endometrium through fine-tuned lymphocytic cells that were highly positive for immunohistochemical markers CD20, CD79a, CD45, positive for CD5 in up to 5% of tumor cells, negative for Cyclin D1, CD10, and bcl-2. The proliferation marker Ki-67 was expressed in approximately 15% of the lymphocytic tumor cells. The patient's uterus and adnexa were surgically removed and she did not receive any additional therapy. After a 3.5-year follow-up, the patient has been without a relapse of the disease. Conclusion Although non-Hodgkin's lymphomas of the genital organs, especially the MALT type of non-Hodgkin's lymphoma, are extremely rare, they should also be considered as a differential diagnosis in women with menometrorrhagia and the ultrasound image of the endometrial polyps.

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Section: Discussionmentioning

confidence: 96%

Primary endometrial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type

et al. 2018

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“…Previous reports indicate that the cervical site is predominantly involved, with 75% of primary ML occurring in the female genital tract;1, 2, 3, 9 however, cervical ML is rare and represents < 0.01% of all cervical tumors 4, 10, 11…”

Section: Discussionmentioning

confidence: 99%

“…Uterine malignant lymphoma (ML) is a rare disease, accounting for approximately 0.05% of malignant tumors of the uterus. [1][2][3] Diagnosis by cervical smear and normal cervical biopsy is difficult because ML tumor cells develop in the endometrial stroma and cause minimal necrosis. 4 The surgery for diagnosis and treatment often leads to major bleeding.…”

Section: Introductionmentioning

confidence: 99%

Two cases of uterine malignant lymphoma diagnosed by needle biopsy

Kasai

Ichimura

Murakami

et al. 2015

J of Obstet and Gynaecol

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The incidence of primary malignant lymphoma arising in the female genital tract is extremely rare and constitutes approximately 0.05% of malignant tumors. Uterine malignant lymphoma develops in the endometrial stroma, causing minimal necrosis. It is therefore difficult to diagnose malignant lymphoma, as it does not involve genital bleeding or epithelial defects. We have performed transcervical needle biopsies from deep in the myometrium, with the purpose of diagnosing uterine muscle layer lesions, such as leiomyosarcoma, but this is an unusual method. In this report, we suggest that transcervical needle biopsy is useful in the diagnosis of uterine malignant lymphoma.

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“…Until present, there have been a considerable number of case reports describing uterine involved NHL. A Medline search resulted in nine case reports describing total of 10 cases of primary uterine lymphoma within the past 5 years [5][6][7][8][9][10][11][12][13]. A summary is shown in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Non-Hodgkin’s Lymphoma Involving the Uterus

Nakayama¹

2014

Gynecol Obstet (sunnyvale)

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Diagnosis of uterine lymphoma is challenging due to its rarity and non-specific presentation. Treatment is also difficult since there is no standard treatment. We report our experience with two cases of lymphoma involving the uterus. The first patient was a 66-year-old with chief complaint of lower abdominal pain. She was diagnosed as lymphoma of the uterus by laparotomy. Chemotherapy failed and she died in the course of a year. The second patient was a 63-year-old who presented with general fatigue. Tissue biopsy and CT scan revealed lymphoma of the stomach with multiple metastases including the uterus. She was treated with chemotherapy followed by radiation therapy, but died 18 months later. Lymphoma involving the uterus is rare and diagnosis can be difficult. Clinicians should be aware of this rare disease for prompt diagnosis. Treatment should be individualized according to the condition of each patient.

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Primary extranodal marginal zone B cell lymphoma of the uterus: a case study and review of the literature

Cited by 8 publications

References 6 publications

Primary endometrial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type

Primary endometrial extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type

Two cases of uterine malignant lymphoma diagnosed by needle biopsy

Two Cases of Non-Hodgkin’s Lymphoma Involving the Uterus

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