Extranodal marginal zone lymphoma of the uterine cervix with concomitant copy number gains of the MALT1 and BCL2 genes: A case report

Abstract

Extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT) of the uterus is rare, and the etiology, pathophysiology and cytogenetic features remain unknown at present. The present study reports a case of a 71-year-old female with EMZL of the uterine cervix that was 80 mm in diameter and invaded directly into the rectal serosa. Complete remission was successfully induced by 6 courses of immunochemotherapy with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisolone. Although the metaphase spread of the tumor cells was unavailable for whole cytogenetic analysis, fluorescence in situ hybridization (FISH) detected triple signals for MALT1 and B-cell lymphoma 2, located at chromosome 18q21, and the centromere of chromosome 18, which was suggestive of trisomy 18, and in combination with previous studies, suggested a possible association between trisomy 18 and the large tumor at initial presentation in the present patient. In addition, FISH examination detected immunoglobulin heavy chain gene rearrangement, although the translocation partner was unconfirmed. A total of 18 previously-studied patients with EMZL of the uterus, including that of the present study, were reviewed with respect to their clinical features and treatment and cytogenetic abnormality. In the evaluation of the English scientific literature, this is the first reported patient with EMZL of the uterus with partly determined cytogenetic abnormalities.

Marginal zone B-cell lymphoma: lessons from Western and Eastern diagnostic approaches

“…MALT lymphoma has been reported infrequently in many sites including the endometrium, 114 uterine cervix, 115 breast, 116 kidney, 117,118 bladder, 119 and prostate. 120,121…”

Biclonal Diffuse Large B-cell Lymphoma Commonly Characterized by Partial Trisomy 18q Involving <i>MALT1</i> and <i>BCL2</i>

“…Seventeen cases of chronic lymphoid leukemia (CLL) were excluded. Dx: diagnosis, FISH: fluorescence in situ hybridization, F: female, M: male, NA: not available, BM: bone marrow, LN: lymph node, PB: peripheral blood, BL: Burkitt lymphoma, FL: follicular lymphoma, MZBCL: marginal zone B-cell lymphoma, DLB-CL: diffuse large B-cell lymphoma, ND: not done FISH, indicating the existence of trisomy 18 (23). They suggested a possible association between trisomy 18 and a large tumor at the initial presentation.…”

“…Trisomy 18 has been characterized mainly by MZBCL ( 21 - 26 ). Takimoto et al detected triple signals of CEP 18, MALT1 and BCL2 in MZBCL cells by interphase FISH, indicating the existence of trisomy 18 ( 23 ). They suggested a possible association between trisomy 18 and a large tumor at the initial presentation.…”