Hematologic Neoplasms and Selected Tumor-Like Lesions Involving the Female Reproductive Organs

Ferry, Judith A.

doi:10.1007/978-1-4614-3165-7_21-2

Cited by 1 publication

(1 citation statement)

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“…1 However, little has been reported about primary ovarian lymphoma, probably because it is difficult to be clinically recognized at an early stage due to its asymptomatic nature. 3 The differential diagnosis of ovarian lymphoma includes chronic inflammatory infiltrates, granulosa-cell tumor, dysgerminoma, small cell carcinoma, metastatic carcinoma and carcinosarcoma. 4 Although immunohistochemistry is effective in many instances, it may not be helpful in differentiating lymphoma in the stroma of carcinoma from inflammatory infiltrates as a stromal reaction to the carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Intravascular Large B-Cell Lymphoma Coexisting with an Ovarian Carcinoma

Uchiyama

Nakamine

Morita

et al. 2016

J Clin Exp Hematopathol

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We report an incidental case of intravascular large B-cell lymphoma (IVLBCL) coexisting with an ovarian carcinoma in a 76-year-old woman. She visited our hospital with difficulty in defecation. Magnetic resonance imaging and computerized tomography scan revealed a solid and cystic mass probably arising from the left ovary. Gross examination of the tumor obtained by an exploratory surgery showed a solid area in a simple cyst. The ovarian tumor was diagnosed as a high-grade serous carcinoma (HGSC). Early in the post-operative course, this patient developed fever of unknown origin with central nervous system manifestations. Magnetic resonance imaging of the brain showed multiple space-occupying lesions. When we reviewed the histological sections, atypical lymphocytes were found in the lumina of small vessels of almost the entire ovary. These cells were positive for CD20 and CD79a by immunohistochemistry. A diagnosis of IVLBCL coexisting with HGSC was finally made. Although radiation therapy for brain lesions was performed and rituximab was administered, she died two months after the operation. To the best of our knowledge, this is the first case of IVLBCL incidentally identified in HGSC through microscopic examination. This case serves to create awareness of the rare event where IVLBCL may involve the ovary of patients who also have carcinoma in the organ.

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Section: Discussionmentioning

confidence: 99%