Extramammary Paget's disease: Surgical treatment with Mohs micrographic surgery

Hendi, Ali; Brodland, David G.; Zitelli, John A.

doi:10.1016/j.jaad.2004.07.004

Cited by 238 publications

(207 citation statements)

References 22 publications

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“…[8,9] Local recurrence is high (31%-61%), so long-term follow-up must be guaranteed. [10] 4. CONCLUSIONS This case illustrates the importance and difficulties encountered in the clinical diagnosis of this infrequent disease.…”

Section: Discussionmentioning

confidence: 99%

Perianal Paget’s Disease with synchronous adenocarcinoma: An unusual diagnosis

Campos

Varela

Baptista

et al. 2016

CRCP

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We present a 45-year-old male Caucasian with a one-year history of perianal erythema resistant to topical corticosteroid and antifungal therapy. Physical examination of the perianal region revealed a painful, non-pruriginous erythema with erosions that involved all the circumference of the anus. No oral and no genital lesions were observed. Serologic and virologic markers were collected and a skin biopsy was performed. The markers turned out to be negative and the biopsy revealed the diagnosis of Perianal Paget Disease (PPD). Imunohistochemistry was positive for CK20, EMA and CEA, and negative for CK7. Digital rectal examination suggested a suspicious thickening in the rectum and colonoscopy revealed the presence of a vegetating mass of the distal rectum. Biopsies of the rectal mass displayed a well-differentiated invasive adenocarcinoma. The patient was proposed to neoadjuvant chemo and radiotherapy, followed by abdominoperineal resection with wide surgical excision and lymph node dissection. This case illustrates the importance and difficulties encountered in the clinical diagnosis of this rare disease.

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Section: Discussionmentioning

confidence: 99%

Perianal Paget’s Disease with synchronous adenocarcinoma: An unusual diagnosis

Campos

Varela

Baptista

et al. 2016

CRCP

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“…16 Despite this, recurrences rates of 27% following Mohs surgery have been reported. 17 Other treatment options are laser ablation, electrodessication and curettage, photodynamic therapy, radiotherapy as well as topical use of bleomycine and 5-fluorouracil. 3 Recently, immunotherapy with topical imiquimod 5% cream has been successfully used to treat isolated cases of EMPD.…”

Section: Discussionmentioning

confidence: 99%

Treatment of vulvar Paget disease with topical imiquimod: a case report and review of the literature

Feldmeyer¹,

Kerl²,

Kamarashev³

et al. 2011

J Dermatol Case Rep

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Background: Extramammary Paget's disease is a cutaneous neoplasm that presents as erythematous crusted patches and plaques reminiscent of contact dermatitis or inverse psoriasis that can be a challenge to treat in a tissue-sparing manner. The most commonly involved site for this rare disorder is the anogenital region. Surgery is considered as the gold standard therapy. In the last years, the topical use of imiquimod cream in the treatment of this condition has been reported.

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“…Ante la confi rmación histológica de enfermedad de Paget y la ausencia de carcinoma invasivo, el tratamiento es esencialmente quirúrgico 4,[7][8][9] . Se recomienda la extirpación mediante cirugía micrográ-fi ca de Mohs 10,11 o extirpación y estudio histológico diferido y reconstrucción en un segundo tiempo operatorio.…”

Section: Discussionunclassified

Enfermedad de Paget perianal

et al. 2010

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Extra mammary Paget disease. Report of one caseExtra mammary Paget disease is rare and mostly affects perianal and vulvar zones, in patients of both sexes and from the sixth decade of life. We report a 66 years old woman with a vulvar Paget disease, subjected to a vulvectomy. Two years later, a pruriginous and erythematous plaque appeared in the perianal region. The pathological study informed an extra mammary Paget disease. The patient was subjected to a perianal excision and the correction of the surgical defect in a second intervention. After one year of follow up, there is no evidence of disease relapse.Key words: Extra mammary Paget disease, vulva, perianal region. ResumenLa enfermedad de Paget de localización extramamaria (EPEM) es una patología infrecuente que afecta preferentemente a zonas perianal y vulvar en pacientes de ambos sexos y desde la sexta década de vida. Presentamos un caso clínico tratado en conjunto por los Servicios de Cirugía General, Cirugía Plástica, Ginecología y Anatomía Patológica del Hospital Universitario de Getafe.Palabras clave: Enfermedad de Paget perianal, colgajos regionales, colgajos locales. CASOS CLÍNICOS IntroducciónLa enfermedad de Paget debe su nombre a James Paget 1 quien publicó una serie de casos de localización mamaria. La primera ubicación extramamaria conocida fue en el escroto. En general la ubicación extramamaria más frecuente es la vulva, siendo la perianal más rara.A diferencia de la enfermedad de Paget de la mama, que siempre está asociada a carcinoma intraductal, en la región perianal puede o no estar asociada a carcinoma subyacente. Debemos considerar además que en un alto porcentaje de casos puede haber asociación con otros tumores de localización tubo ováricos y colorrectales.Aunque las alternativas terapéuticas publicadas pueden ser variadas, la extirpación amplia suele ser lo más recomendado, generando defectos que deben ser reconstruidos mediante colgajos locales o regionales principalmente.

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Extramammary Paget's disease: Surgical treatment with Mohs micrographic surgery

Cited by 238 publications

References 22 publications

Perianal Paget’s Disease with synchronous adenocarcinoma: An unusual diagnosis

Perianal Paget’s Disease with synchronous adenocarcinoma: An unusual diagnosis

Treatment of vulvar Paget disease with topical imiquimod: a case report and review of the literature

Enfermedad de Paget perianal

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