Extramammary Paget's disease of the breast: an unusual location with prognostic implications

Piñero, Antonio; Illana, Julián; Martínez‐Barba, Enrique; Sola, Joaquı́n; Parrilla, Pascual

doi:10.1016/j.breast.2004.09.012

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…Very rarely, no underlying tumour is found despite a thorough investigation 17 . These cases are called ‘MPD stage 0’; they have been occasionally termed ‘extramammary Paget's disease of the breast’ 18 …”

Section: Mammary Paget's Diseasementioning

confidence: 99%

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Mammary and extramammary Paget's disease

Kanitakis

2007

Acad Dermatol Venereol

274

287

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Paget's disease is an intra-epidermal adenocarcinoma seen over the nipple/areola (mammary Paget's disease) or in extramammary body zones, such as the anogenital and perineal skin and the axilla. Mammary and extramammary Paget's disease share many common clinicopathological features but also show several differences, namely, with regard to pathogenesis and association with underlying malignancies. Indeed, mammary Paget's disease is as a rule associated with an underlying breast carcinoma whereas association of extramammary Paget's disease with underlying (skin or visceral) malignancies occurs much less frequently. We review here the main clinicopathological and therapeutic features of mammary and extramammary Paget's disease.

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Section: Mammary Paget's Diseasementioning

confidence: 99%

“…17 These cases are called 'MPD stage 0'; they have been occasionally termed 'extramammary Paget's disease of the breast'. 18 MPD can very rarely be associated with vulvar Paget's disease. 19 Other rarely reported associations (pemphigus vulgaris and systemic scleroderma) seem fortuitous.…”

Section: Association With Breast Cancermentioning

confidence: 99%

Mammary and extramammary Paget's disease

Kanitakis

2007

Acad Dermatol Venereol

274

287

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“…Secondary EMPD including noncutaneous adenocarcinomas from contiguous sites and urothelial carcinoma is not encountered in mammary skin. Our review of the current English language literature has revealed only one reported case of EMPD of the breast (14). The authors describe a 58‐year‐old woman with a progressive ulcerative skin lesion involving most of the skin of the right breast, but which originated with the nipple‐areolar skin.…”

Section: Discussionmentioning

confidence: 99%

Acinar Pattern of Mammary Paget?s Disease: A Case Report

Barnes¹,

Dumont²,

Higgins

2007

Breast Journal

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Mammary Paget's disease (MPD) is an uncommon in situ neoplasm of the nipple-areolar complex and surrounding skin. It is almost always associated with mammary ductal carcinoma in situ (DCIS), high-grade or invasive carcinoma, usually of ductal origin. MPD has only rarely been described in association with specialized forms of breast carcinoma. We report an unusual case of an acinar pattern of MPD with low-grade cytological atypia, associated with invasive papillary carcinoma and micropapillary DCIS of the lactiferous ducts, in an 83-year-old woman. Most cases of MPD are characterized by intraepidermal spread of discohesive glandular epithelial cells with high-grade nuclear atypia. A predominant acinar pattern of MPD is extremely uncommon and, to our knowledge, has not been formally reported. The histological features and differential diagnosis are discussed.

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“…Paget's disease (PD) is a skin cancer characterized by epidermal infiltration of glycogen-rich vacuolated cells, termed Paget's cells, which usually present as single cells or nests 1 2 . Otherwise, extramammary PD commonly shows the various patterns of Paget's cells including the glandular pattern.…”

mentioning

confidence: 99%

“…Almost all mammary PD involves underlying breast cancer. However, there have been rare reports of mammary PD without underlying malignancy 1 , which are also referred to as mammary PD stage 0, or extramammary PD of the breast 1 . It has been suggested that Toker cells may be potential precursor cells in cases of PD without underlying breast cancer 4 .…”

mentioning

confidence: 99%