Acinar Pattern of Mammary Paget?s Disease: A Case Report

Barnes, Penny J.; Dumont, R; Higgins, H. Gayle

doi:10.1111/j.1524-4741.2007.00477.x

Cited by 12 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An alternative view is that rare cases result from neoplastic transformation of pre‐existing, innocent intraepidermal clear cells of the nipple‐areolar complex (Toker cells) that migrate from nonneoplastic ducts (9,12). Two rare cases of Paget’s disease of nipple with acinar arrangement pointed on architectural resemblance to Toker’s original description of the non‐neoplastic cells that often form glandular structures was presented to support this theory (13,14).…”

Section: Discussionmentioning

confidence: 79%

Toker Cells Revisited

Nofech‐Mozes¹,

Hanna²

2009

The Breast Journal

View full text Add to dashboard Cite

Toker cells are inconspicuous cytokeratin 7 positive cells that should be distinguished from intraepidermal involvement by malignant cells seen in Paget's disease (PD) of the nipple. The aim of our study was to quantitatively assess the number and pattern of distribution of Toker cells in nipples without PD in mastectomy specimens. Sequential sections from the nipple of 173 mastectomies were evaluated using HE and immunohistochemistry. Two breast pathologists reviewed the stains and recorded the number and pattern of distribution of CK7 positive cells (CK7+) and their HER2/neu, ER and PR status. There were 152/173 (88.4%) cases with CK7+ cells. The mean number of CK7+ cells per section was 22 (range 0-200) and the mean number of CK7+ cells per field at 10x was 10 (range 0-106). 10/37 (27%) of nipples from prophylactic mastectomies and 15/136 (11.1%) of mastectomies for cancer displayed over 10 CK7+ cells in an area of 10x. In 32/173 (18.5%) CK7+ cells formed small groups or clusters. Notably these cells were not restricted to the basal part of the epidermis. None of the groups/clusters of Toker cells were appreciated on HE stain and all were HER2/neu, ER and PR negative. The absence of any CK7+ cells in 20 cases occurred in hyperpigmented epidermis, possibly obscuring rare positive cells. Toker cells are frequently present in the epidermis of the nipple and are more prevalent than appreciated on routine HE stain. These cells can be present in clusters and can have pagetoid pattern of distribution. They occur in nipples of cancer patients with or without PD and in prophylactic mastectomies performed for high risk patients. The substantial number and the clustering of Toker cells should not be mistaken for PD of the nipple. Unlike PD, Toker cells have small bland nuclei and are characterized by CK7+ and HER2/neu ER and PR negative immunoprofile.

show abstract

Section: Discussionmentioning

confidence: 79%

Toker Cells Revisited

Nofech‐Mozes¹,

Hanna²

2009

The Breast Journal

View full text Add to dashboard Cite

show abstract

“…Это свя-зано с тем, что клиническая картина схожа с другими заболеваниями, такими как атопический или контакт-ный дерматит соска (встречается у беременных и кор-мящих женщин), псориаз (отмечаются также другие локализации данной патологии), эрозивный аденома-тоз соска, гиперкератоз соска и САК, болезнь Боуэна, гистиоцитоз Лангерганса и т. д. [40][41][42]. Эти состояния могут быть подтверждены гистологическими и имму-ногистохимическими исследованиями [28,43].…”

Section: диагностика обзорные статьиunclassified

Paget’s disease of the breast (a review of literature)

Никитина¹,

Нечушкин²,

Trigolosov³

et al. 2016

Tumors of female reproductive system

View full text Add to dashboard Cite

show abstract

“…10 Immunohistochemistry is a powerful tool in detecting the molecular subtypes of PDB contributing to the staging, therapy selection and prognosis prediction of this disease, meanwhile in differentiated from other nippleassociated lesions including nipple adenoma, malignant melanoma, pagetoid Spitz nevus, florid papillomatosis of the nipple, and so on. [18][19][20][21] In our study we use a immunohistochemical profile including ER, PR, Ki-67, and HER-2 to exam thoroughly the molecular subtypes of PDB which can deep our understanding of this rare disease. Based on classifying different subtypes of PDB, rational therapies will be applicated in clinical cases and a better cure for the disease can be achieved.…”

Section: Introductionmentioning

confidence: 99%

Using immunohistochemistry to classify the molecular subtypes of Paget's disease of the breast

et al. 2023

View full text Add to dashboard Cite

Purpose To classify the molecular subtypes of Paget's disease of the breast, and then compare them with general breast cancer to get deeper understanding of this disease and offer better management of associate patients in clinical decisions. Methods We used immunohistochemistry to examine 42 cases of this disease by antibodies against estrogen and progesterone receptors, Ki‐67, as well as human epidermal growth factor receptor 2 (HER‐2). Due to damage and loss of specimens, etc., we obtained 36 pathological specimens from the 42 patients. For 30 of 36 pathological specimens (83.3%), we obtained a complete molecular subtype. Cause the other 6 pathological specimens have missing immunohistochemistry items. For patients with bilateral breast cancer, only information on the side with PDB is listed. For patients with recurrence, only information on the first onset was included. We finally compared and studied the molecular subtype of 26 samples. We calculated the relative frequencies of molecular subtypes including luminal A, luminal B, HER‐2‐enriched, and basal‐like and compared them between PDB and general breast carcinomas in other studies. Results The luminal A and B subtype were found, respectively, in 3 (11.5%) and 6 (23.1%) of all patients, and 15 cases of HER‐2‐enriched subtype was detected (57.7%). In addition, 2 (7.7%) showed a basal‐like subtype. Conclusion The molecular subtypes of common breast cancer and PDB‐associated breast cancer differ. Luminal subtypes are the most common in the former, while within our samples HER‐2 positive subtype was the highest in PDB‐associated breast carcinoma. With further understanding of this disease, rational therapies will be applied in different patients and cures for PDB and PDB‐associated carcinoma will be achieved.

show abstract

Acinar Pattern of Mammary Paget?s Disease: A Case Report

Cited by 12 publications

References 17 publications

Toker Cells Revisited

Toker Cells Revisited

Paget’s disease of the breast (a review of literature)

Using immunohistochemistry to classify the molecular subtypes of Paget's disease of the breast

Contact Info

Product

Resources

About