Extraintestinal manifestations in inflammatory bowel disease: Prevalence and predictors in Indian patients

Bandyopadhyay, Debottam; Bandyopadhyay, Sanjay; Ghosh, Parasar; De, Abhishek; Bhattacharya, Anupam; Dhali, Gopal Krishna; Das, Kshaunish

doi:10.1007/s12664-015-0598-8

Cited by 46 publications

(53 citation statements)

References 40 publications

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“…In this study, 41 (39.8%) patients had a minimum of one EIM. This was comparable to findings from a study conducted in India, which stated a prevalence of 38% EIM in IBD [8]. The prevalence in our study was slightly higher.…”

Section: Discussionsupporting

confidence: 90%

“…The pathogenesis of erythema nodosum as an EIM of CD can be explained as an abnormal immune response that causes a release of cytokines including tumor necrosis factors and interleukins. These inflammatory signals are directed against common epitopes between intestinal bacteria and skin [8]. The nodules' appearance correlates with intestinal activity; they rarely precede the onset of CD or appear during quiescent phases of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral arthritis was reported in 13 participants (12.62%), which is low in comparison to a regional study conducted in India, which reported a prevalence of 23% [8]. Peripheral arthropathies occur in 5-20% of patients with IBD and are generally most common in CD [15].…”

Section: Discussionmentioning

confidence: 99%

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The Spectrum of Extra-intestinal Manifestation of Crohn's Disease

Jumani

Kataria

Ahmed

et al. 2020

Cureus

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Spectrum of Extra-intestinal Manifestation of Crohn's Disease

Jumani

Kataria

Ahmed

et al. 2020

Cureus

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“…and ). Then, 378 full texts were assessed for eligibility and, finally, 78 papers were included in the qualitative and quantitative analysis: 67 for the analysis of the prevalence of co‐existing IBD‐SpA (Tables and ) and only 11 for the diagnostic accuracy of red flags .…”

Section: Resultsmentioning

confidence: 99%

Red flags for appropriate referral to the gastroenterologist and the rheumatologist of patients with inflammatory bowel disease and spondyloarthritis

Felice

Leccese

Scudeller

et al. 2019

Clinical and Experimental Immunology

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Collaboration between gastroenterologists and rheumatologists is recommended for the correct management of patients with associated spondyloarthritis (SpA) and inflammatory bowel disease (IBD). We aimed to establish the appropriateness of several red flags for a prompt specialist referral. A systematic review of the literature was performed using the GRADE method to describe the prevalence of co-existing IBD-SpA and the diagnostic accuracy of red flags proposed by a steering committee. Then, a consensus among expert gastroenterologists and rheumatologists (10 in the steering committee and 13 in the expert panel) was obtained using the RAND method to confirm the appropriateness of each red flag as 'major' (one sufficient for patient referral) or 'minor' (at least three needed for patient referral) criteria for specialist referral. The review of the literature confirmed the high prevalence of co-existing IBD-SpA. Positive and negative predictive values of red flags were not calculated, given the lack of available data. A consensus among gastroenterology and rheumatology specialists was used to confirm the appropriateness of each red flag. Major criteria to refer patients with SpA to the gastroenterologist included: rectal bleeding, chronic abdominal pain, perianal fistula or abscess, chronic diarrhoea and nocturnal symptoms. Major criteria to refer patients with IBD to the rheumatologist included: chronic low back pain, dactylitis, enthesitis and pain/swelling of peripheral joints. Several major and minor red flags have been identified for the diagnosis of co-existing IBD-SpA. The use of red flags in routine clinical practice may avoid diagnostic delay and reduce clinic overload.

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“…Except for the study by Pokharna et al [77] which reported a lower prevalence of extra-intestinal manifestations (EIMs) in Indian patients as compared to those from the West, other studies indicate that the overall prevalence of EIMs in Indian patients is comparable [78,79] . In a study from our centre, the overall prevalence of any EIM and multiple EIMs in UC and CD was 33.2 versus 38.3% and 6.9 versus 4.7%, respectively [80] .…”

Section: Extra-intestinal Manifestationsmentioning

confidence: 99%