Extraction Spectrophotometric Determination of Lidocaine Using Flow Injection Analysis

Němcová, I.; Rychlovský, Petr; Tománková, V.; Živanović, Ljubiša

doi:10.1081/al-100107527

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Detection limit (M) 7.48×10 -6 Quantitation limit (M) 1.73×10 -5 CTAB has been determined by using different spectroscopic methods based on colorant ion pairing formation, with typical ranges of LODs from 0.12 to 0.38 µM by using Resonance Rayleigh scattering with BPB 42 and Eosin Y 43 , Resonance light scattering with azoviolet 44 and Fluorescence quenching with eosin Y 45 . Meanwhile, the lower LODs have been obtained by flow injection analysis using Cu(II)-chromazurol S-surfactants complexes 46 (0.05 µM) and by complexes formation of Al 3+ and Be 2+ withChromeAzurol S 47 (0.025 µM). Finally, LODs of 0.8 µM and 3 µM have been obtained by using a spectrophotometric method with sequential injection 48 and non-extraction flow injection using eriochromeblack-T, respectively 49 .In this sense, our method presents a LOD and LOQ that allow establishing whether a solution of GNRs contains cytotoxic concentration.…”

Section: Analytical Developmentmentioning

confidence: 99%

Ion Pair Method to Determine the Ctab Content in Gold Nanorods Samples

Adura

Guzmán

Álvarez‐Lueje

et al. 2014

J. Chil. Chem. Soc.

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In this work, we report a fast and accessible method for quantification of cetyltrimethylammonium bromide (CTAB) in solutions of gold nanorods (GNRs) by bromophenol blue (BPB) ion-paring formation and spectrophotometric detection. The ion-par method used to quantify CTAB exhibited adequate figures of merit and was applied to the quantification of CTAB present in solutions of GNRs-CTAB and in GNRs-CLPFFD samples obtained by the seed growth method. This type of methodology could be extensive to others surfactants employed for the synthesis of nanoparticles. In addition, this method allows screening CTAB in GNRs samples and consequently would help to know if CTAB concentration is lower than an acceptable cutoff for cell viability analysis.

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Section: Analytical Developmentmentioning

confidence: 99%

Ion Pair Method to Determine the Ctab Content in Gold Nanorods Samples

Adura

Guzmán

Álvarez‐Lueje

et al. 2014

J. Chil. Chem. Soc.

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“…In addition to HPLC methods of analysis for determination of LD and BZ in pharmaceutical formulations [12][13][14][15][16][17][18][19][20][21][22], analytical methods based on electrochemical [23][24][25][26][27] and spectrophotometric [28][29][30][31] detections have also been reported in the literature. Beyond quantification of LD in pharmaceutical formulations [32][33][34][35], CE has also been applied for the determination of this anesthetic in urine [36][37][38], human plasma [39,40], human serum [41,42], vitreous humor [43], and seized cocaine [6,9].…”

Section: Introductionmentioning

confidence: 99%

A simple and fast method for determination of benzocaine and lidocaine in pharmaceutical formulations by capillary electrophoresis with spectrophotometric detection

Junger

Jesus

Silva

et al. 2019

Separation Science Plus

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A novel, simple, and rapid method for the determination of the anesthetics benzocaine and lidocaine in pharmaceutical formulations using capillary electrophoresis with spectrophotometric detection (210 nm) is proposed. In this method, the sample preparation was fast and simple, using only aqueous dilution or extraction with sonication aid. A background electrolyte composed by 10 mmol L ‐1 of monosodium phosphate with pH 2.1 allowed the separation of the anesthetics with good peak resolution in less than 5 min. The limits of quantification were 0.31 and 0.68 mg L−1 for lidocaine and benzocaine, respectively. The intra‐ and inter‐day precisions (RSD%) ranged from 1.1 to 4.8% and the accuracies (as recovery percentage) varied from 84 to 109.4%. The proposed method was successfully applied for analyses of commercial samples of pharmaceutical formulations, such as otologic solution, ointment, and spray solution and lozenges for sore throat.

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“…Reviewing the literature, many methods were used for the determination of each of the studied drugs individually or in combination with other drugs including spectrophotometric, [14][15][16][17][18][19][20][21][22][23] thin-layer chromatography, [24][25][26][27][28] and HPLC [29][30][31][32][33][34][35][36] methods. To date, no methods have been used for the simultaneous determination of this ternary mixture in the presence of interfering excipients.…”

mentioning

confidence: 99%

Simultaneous analysis of oxytetracycline hydrochloride, lidocaine, and bromhexine hydrochloride in the presence of many interfering excipients

Mahmoud

Naguib

Abdelfatah

2021

Archiv der Pharmazie

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A gradient elution high‐performance liquid chromatographic method with a diode array detector is introduced for the first time for the simultaneous estimation of three drugs, namely, oxytetracycline hydrochloride (OXT), lidocaine (LDC), and bromhexine hydrochloride (BRH), in a veterinary formulation (OxyClear® solution) that contains many interfering additives. The method used a C‐8 column. The chromatographic eluting solution included acidified water (0.1% trifluoroacetic acid in water) and acetonitrile at a 1‐ml/min flow rate and 254 nm as a nominated detection wavelength. The chromatographic process was assessed in terms of linearity, precision, accuracy, LOD, and LOQ. OXT, LDC, and BRH were linear in the range of 1–60, 5–100, and 1–60 μg/ml, respectively. The three drugs were determined successfully without the interference of three excipients having UV absorbances. Furthermore, the purities of the peaks of the three drugs were confirmed by comparing the UV spectra of investigated peaks to the UV reference spectra in Clarke's Analysis of Drugs and Poisons. The greenness value of the method was 0.69 with a faint green‐colored pictogram using the AGREE tool. These merits recommend the application of the planned method in QC laboratories for purity testing and concentration assays for the pure drugs and commercial formulations.

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Extraction Spectrophotometric Determination of Lidocaine Using Flow Injection Analysis

Cited by 7 publications

References 9 publications

Ion Pair Method to Determine the Ctab Content in Gold Nanorods Samples

Ion Pair Method to Determine the Ctab Content in Gold Nanorods Samples

A simple and fast method for determination of benzocaine and lidocaine in pharmaceutical formulations by capillary electrophoresis with spectrophotometric detection

Simultaneous analysis of oxytetracycline hydrochloride, lidocaine, and bromhexine hydrochloride in the presence of many interfering excipients

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