Extraction of phenolic compounds from Iraqi Coriandrum Sativum L. and loaded on copolymeric hydrogels and examine there as drug delivery system and antioxidant

Abstract

The phenolic extracts for leaves and stems (L+S) parts and leaves (L) part of Iraqi Coriandrum Sativum L. and their total phenols, total tannins and total flavonoids are described. Three copolymeric hydrogels prepared and loaded with phenolic extract 4 (U1-U3). The HPLC results show three phenolic compounds, while the GC-Mass results show one phenolic compound and four non-phenolic compounds. Gained results showed that there are significant (P < 0.05) variations in total phenols (9.822 ± 0.634−4.015 ± 0.118 mg GAE/g DW), total flavonoids (8.112 ± 0.115−2.811 ± 0.371 mg QE/g DW) and total condensed tannin (4.245 ± 0.276−1.135 ± 0.091 mg QE/g DW) contents for all phenolic extracts. The swelling rate for (U1-U3) in distilled water, the SGF, and the SIF was estimated. The maximum swelling was observed in copolymeric hydrogels at pH 6.9 in distilled water. The IC50 values of radical scavenging activity of the phenolic extracts 4, 8 and phenolic extract 4 released from copolymeric hydrogels (U1-U3) show varied significantly (P < 0.05). Our results indicated that Iraqi Coriandrum Sativum L. could constitute a rich and novel source of natural antioxidants. When it loaded on, copolymeric hydrogels could be used as a drug delivery system.

Total phenol contents, total flavonoid contents, antioxidant activities of Methanol extracts of Amomum Subulatum, Lippia adoensis, Coriandram sartivum, and Ruta chalepensis sold from Jigjiga market, Ethiopia

“…This value is almost 25 2021). The result of this study, the ethanolic extracts of the leaves and leaves with steam were more potent than the ethanolic extracts of the leaves alone, the ethanolic extracts of the leaves with steam, and the methanolic extracts (35).…”

Quantitative and Qualitative Analysis and Evaluation of Antioxidant Activity of Phenolic Compounds Extracted from Apiaceae Family Spices

“…Regarding these results, coriander flavonoids are much higher than those reported by (Msaada et al, 2017) who observed that the flavonoid contents in Syria and Egypt were 2.51 and 2.07 mg QE/gDw, respectively. In Iraq, (Sadoun et al, 2021) analyzed the flavonoid contents of the ethanolic extract of coriander which was ranged from 3.422 to 8.112 mg QE/g DW. This value is close to the present obtained results, while the methanolic extract was about (2.811-3.793) mg QE/g Dw (Sadoun et al, 2021).…”

“…In Iraq, (Sadoun et al, 2021) analyzed the flavonoid contents of the ethanolic extract of coriander which was ranged from 3.422 to 8.112 mg QE/g DW. This value is close to the present obtained results, while the methanolic extract was about (2.811-3.793) mg QE/g Dw (Sadoun et al, 2021). Other studies carried out in Morocco by (Derouich et al, 2020) demonstrated that the total flavonoids reached 10.24 mg QE/g DW in the methanolic extract of coriander.…”

Synthesis and characterization of some thioether compounds by thiol-ene click chemistry

“…The using of biomass versus petroleum resources needs to determine the choice among them through the efficiency and sustainability of the production of this biomass, and this means the necessity to set priorities for the allocation of biomass, due to direct competition between food, energy, fodder and industrial raw materials in terms of price and Abundance and non-food competitiveness [1,2] , so the materials used in this research were selected on this basis after studying the extent of their competitiveness and the possibilities of their work in medical and other fields, and all of that is from extracting the raw materials for their synthesis and treatment from available materials in nature or waste [3][4][5][6][7] .…”