The phenolic extracts for leaves and stems (L+S) parts and leaves (L) part of Iraqi Coriandrum Sativum L. and their total phenols, total tannins and total flavonoids are described. Three copolymeric hydrogels prepared and loaded with phenolic extract 4 (U1-U3). The HPLC results show three phenolic compounds, while the GC-Mass results show one phenolic compound and four non-phenolic compounds. Gained results showed that there are significant (P < 0.05) variations in total phenols (9.822 ± 0.634−4.015 ± 0.118 mg GAE/g DW), total flavonoids (8.112 ± 0.115−2.811 ± 0.371 mg QE/g DW) and total condensed tannin (4.245 ± 0.276−1.135 ± 0.091 mg QE/g DW) contents for all phenolic extracts. The swelling rate for (U1-U3) in distilled water, the SGF, and the SIF was estimated. The maximum swelling was observed in copolymeric hydrogels at pH 6.9 in distilled water. The IC50 values of radical scavenging activity of the phenolic extracts 4, 8 and phenolic extract 4 released from copolymeric hydrogels (U1-U3) show varied significantly (P < 0.05). Our results indicated that Iraqi Coriandrum Sativum L. could constitute a rich and novel source of natural antioxidants. When it loaded on, copolymeric hydrogels could be used as a drug delivery system.
The biosynthesis of silver nanoparticles (AgNPs) was conducted using the Iraqi Jasminum sambac (L.) Aiton leaves having substantial bioreduction and capping properties. The aqueous extract has been characterized using FTIR to observe changes in functional groups of extract compared to extract-AgNPs. GC-MS understands the mechanism synthesis of AgNPs based on the aqueous extract of J. sambac through identification of aqueous extracted. The synthesized AgNPs were characterized using UV–Vis at 455[Formula: see text]nm, XRD broad chart owing to size of AgNPs and TEM (AgNPs average size less than 10[Formula: see text]nm). FESEM-EDX was carried out to observe the nearly spherical shape with elemental composition. DLS was appointed with hydrodynamic radius as 105.9[Formula: see text]nm and also had a good polydispersity at 0.357, and [Formula: see text]-potential at [Formula: see text]23.1. AgNPs have antibacterial gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli), cytotoxicity MTT assay against breast cancer MCF-7 cell line IC50 at 222.6[Formula: see text][Formula: see text]g/mL, genotoxicity fragmented DNA of MCF-7 by comet assay, emphasized apoptosis cells through cell cycle flow cytometry. Overall, safe, cost-effective, and scalable biogenic nano-formulation of Jasminum sambac-AgNPs possesses antibacterial and anticancer therapeutic applications.
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