Extraction of chitosan from Aspergillus niger mycelium and synthesis of hydrogels for controlled release of betahistine

Muñoz, Gustavo A.; Llano, Carlos Humberto Valencia; Valderruten, Nora E.; Ruiz-Durántez, Eduardo; Zuluaga, Fabio

doi:10.1016/j.reactfunctpolym.2015.03.008

Cited by 67 publications

(43 citation statements)

References 53 publications

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“…Chitosan is not found abundantly in nature, but is produced from chitin, mostly from crab shells, shrimp shells, squid pens and, in some cases, from filamentous fungi, via a heterogeneous deacetylation process (Kumaresapillai et al, 2011;Muñoz et al, 2015;Nwe et al, 2011), where solid chitin is soaked in 40-50% (w/v) NaOH. Chitin is normally deacetylated to remove over 80% of the acetyl groups from the N-acetyl-d-glucosamine residues, converting it into d-glucosamine, to yield chitosan.…”

Section: Chitosan Structures and Physicochemical Characteristicsmentioning

confidence: 99%

Biostimulant activity of chitosan in horticulture

Pichyangkura

Chadchawan

2015

Scientia Horticulturae

329

164

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Section: Chitosan Structures and Physicochemical Characteristicsmentioning

confidence: 99%

Biostimulant activity of chitosan in horticulture

Pichyangkura

Chadchawan

2015

Scientia Horticulturae

329

164

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“…Deacetylation degree (DD) Potentiometric titration [27,28] Elemental analysis [29] Fourier transform infrared (FTIR) [30][31][32][33] Nuclear magnetic resonance (NMR) [34][35][36] Molecular weight (MW) Viscometry [37,38] Gel permeation chromatography (GPC) [37,39,40] Biological Activities and Application of Marine Polysaccharidesglutaric acid. The cross-linking of chitosan with glutaraldehyde and sulfosuccinic acid has been used to generate membranes with a good proton conductivity, which makes them useful in fuel cells [44].…”

Section: Chitosan Property Characterization Methodsmentioning

confidence: 99%

“…Due to the nucleophilic character of amino groups, they are used widely to react with the cross-linking agent. Therefore, chitosan chains are typically cross-linked with dialdehydes: glyoxal and glutaraldehyde [29]. Figure 4 shows the scanning electron microscopy (SEM) for a chitosan hydrogels cross-linked with glyoxal and…”

Section: Cross-linkingmentioning

confidence: 99%

Chitosan, Chitosan Derivatives and their Biomedical Applications

Muñoz¹,

Corrales²

2017

Biological Activities and Application of Marine Polysaccharides

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Chitosan is one of the most studied polysaccharides nowadays. Because of its biocompatibility, biodegradability and abundance in nature, it has had a wide number of applications. In this chapter, an overview of chitosan including its physicochemical properties and characterization methods is presented. Subsequently, the main chitosan chemical modiications via the hydroxyl and amino groups are discussed. These chemical modiications improve chitosan physical properties and expand its range of applications especially in the biomedical ield which will also be studied.

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“…Furthermore, the thermal stability of chitinous polymers is dependent on some parameters such as the DA/DD, the Mw and the CI . The thermal properties are assessed through thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) …”

Section: Characterization Techniques Of Chitinous Polymersmentioning

confidence: 99%

“…Muñoz et al . reported the preparation of hydrogels using chitosan extracted from the mycelium of A. niger .…”

Section: Applications Of Fungal Chitin Chitosan and Chitin/chitosan–mentioning

confidence: 99%

Chitinous polymers: extraction from fungal sources, characterization and processing towards value‐added applications

Araújo

Ferreira

Torres

et al. 2020

J of Chemical Tech & Biotech

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Chitin, chitosan and their complexes with β‐glucan (chitin–glucan complex, CGC, and chitosan–glucan complex, ChGC) are value‐added polysaccharides extracted from the cell‐walls of many fungi. Commercial chitin and its deacetylated form, chitosan, are currently obtained from marine waste material, mostly animal sources (crustaceans and marine invertebrates), through harsh chemical procedures that have low reproducibility due to the variability of the composition of the sources and their seasonal character. These disadvantages are overcome by using fungi as sources of chitinous polymers. The extraction of chitin/chitosan from fungi cell‐walls has the great advantage of yielding products with stable composition and properties, using simpler procedures, with the added benefit of also generating CGC and ChGC, two copolymers that combine the proven properties of chitin/chitosan with those of β‐glucans. Over the last decades, fungal chitinous polymers have been the focus of extensive research that included optimization of the cultivation conditions of a wide range of species and the development of optimized extraction, purification and characterization techniques, as well as the demonstration of the biopolymers' biological properties, which include immunomodulatory, anticancer, antioxidant and antimicrobial activity. Given these properties, several attempts were made to develop applications for them in areas ranging from biomedicine and pharmaceuticals to food and agriculture. Despite their wide range of proven functional properties that include the ability to form different polymeric structures, as well as biological activity, fungal chitinous biopolymers are still underexplored. Nevertheless, these biopolymers hold great potential for development into valuable products or applications that are surely worth further investigation. © 2019 Society of Chemical Industry

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Extraction of chitosan from Aspergillus niger mycelium and synthesis of hydrogels for controlled release of betahistine

Cited by 67 publications

References 53 publications

Biostimulant activity of chitosan in horticulture

Biostimulant activity of chitosan in horticulture

Chitosan, Chitosan Derivatives and their Biomedical Applications

Chitinous polymers: extraction from fungal sources, characterization and processing towards value‐added applications

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