Chitosan, Chitosan Derivatives and their Biomedical Applications

Muñoz, Gustavo A.; Corrales, Héctor Fabio Zuluaga

doi:10.5772/66527

Cited by 39 publications

(25 citation statements)

References 84 publications

(94 reference statements)

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“…4 Chitosan, the deacetylated derivative of chitin, was obtained by Rouget in 1859 by heating chitin in alkaline medium; however, its chemical structure was determined only in 1950. 5 Despite this early discovery, the industrial production and commercialization of chitin and chitosan initially started in the 1970s. 6 Chitin is a hard, inelastic, N-acetylated aminopolysaccharide ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Current state of chitin purification and chitosan production from insects

Hahn

Tafi

Paul

et al. 2020

J of Chemical Tech & Biotech

209

113

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Chitin, and especially its deacetylated variant chitosan, has many applications, e.g. as carrier material for pharmaceutical drugs or as a flocculant in wastewater treatment. Despite its versatility and accessibility, chitin, the second most abundant polysaccharide on Earth, has so far been commercially extracted only from crustaceans and to a minor extent from fungi. Insects are a viable alternative source of chitin, but they have not been exploited in the past due to limited availability. Today however, for the sustainable production of animal feed, insect farming is being developed substantially. The availability of large quantities of insect biomass and chitin-rich side products such as exuviae and exoskeletons has been increasing. This review provides an overview of recently published studies of chitin extraction from insects, its subsequent conversion into chitosan and the primary analytical methods used to characterize insect-based chitin and chitosan. We have discovered a large number of research articles published over the past 20 years, confirming the increased attention being received by chitin and chitosan production from insects. Despite numerous publications, we identified several knowledge gaps, such as a lack of data concerning chitin purification degree and chitosan yield. Furthermore, analytical methods used to obtain physicochemical characteristics, structural information and chemical composition meet basic qualitative requirements but do not satisfy the need for a more quantitative evaluation. Despite the current shortcomings that need to be overcome, this review presents encouraging data on the use of insects as an alternative source of chitin and chitosan in the future.

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Section: Introductionmentioning

confidence: 99%

Current state of chitin purification and chitosan production from insects

Hahn

Tafi

Paul

et al. 2020

J of Chemical Tech & Biotech

209

113

View full text Add to dashboard Cite

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“…Phosphorylated chitosan can be prepared by heating chitosan with orthophosphoric acid in N, N-dimethylformamide (DMF). Chitosan nanoparticles have been prepared and put to use for catalytic functions too [ 240 , 241 ].…”

Section: The State-of-the-art Chitosan Trendsmentioning

confidence: 99%

Crustacean Waste-Derived Chitosan: Antioxidant Properties and Future Perspective

Muthu¹,

Gopal

Chun

et al. 2021

Antioxidants

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Chitosan is obtained from chitin that in turn is recovered from marine crustacean wastes. The recovery methods and their varying types and the advantages of the recovery methods are briefly discussed. The bioactive properties of chitosan, which emphasize the unequivocal deliverables contained by this biopolymer, have been concisely presented. The variations of chitosan and its derivatives and their unique properties are discussed. The antioxidant properties of chitosan have been presented and the need for more work targeted towards harnessing the antioxidant property of chitosan has been emphasized. Some portions of the crustacean waste are being converted to chitosan; the possibility that all of the waste can be used for harnessing this versatile multifaceted product chitosan is projected in this review. The future of chitosan recovery from marine crustacean wastes and the need to improve in this area of research, through the inclusion of nanotechnological inputs have been listed under future perspective.

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“…Due to its physicochemical and biological properties, chitosan and its derivatives are considered to be versatile biomaterials with various biological activities [152][153][154][155][156][157][158][159].…”

Section: Chitosan In Dressing Materialsmentioning

confidence: 99%

Modulating the Physicochemical Properties of Chitin and Chitosan as a Method of Obtaining New Biological Properties of Biodegradable Materials

Latańska¹,

Rosiak²,

Paul³

et al. 2021

Chitin and Chitosan - Physicochemical Properties and Industrial Applications [Working Title]

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Physical and chemical modifications of chitin and chitosan allow for obtaining new functional properties of the natural polymers. This is a particularly valuable feature for the design and manufacture of new materials for medical applications. Due to their wide and varied biological activity, chitin and chitosan materials are increasingly used as dressing materials with antibacterial and hemostatic properties and as materials accelerating the regeneration of damaged tissues because of stimulation of granulation tissue formation, re-epithelialization and reduction of the formation of scar tissue. In addition, chitosan derivatives have antifungal, antiviral, anticancer activity. The increasing use of chitin and chitosan also has a positive impact on the environment, as it is obtained as a result of chitin deacetylation, usually isolated from shellfish shells. The main source of chitin is waste coating of crustaceans. The annual natural reproducibility of chitin by biosynthesis is estimated at 2–3 billion tons. Our interest in the use of biodegradable biopolymers derived from chitin concerns the design, synthesis in laboratory scale, testing new material properties and the final implementation of new developments for industrial practice of new dressing materials useful in the treatment of bleeding wounds (haemostatic properties) as well as in the regeneration of wounds and ulcers of various etiologies. Examples of chitin-based dressing materials introduced by Tricomed SA are Medisorb R Ag, Medisorb R Membrane, Medisorb R Powder and Tromboguard®.

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Chitosan, Chitosan Derivatives and their Biomedical Applications

Cited by 39 publications

References 84 publications

Current state of chitin purification and chitosan production from insects

Current state of chitin purification and chitosan production from insects

Crustacean Waste-Derived Chitosan: Antioxidant Properties and Future Perspective

Modulating the Physicochemical Properties of Chitin and Chitosan as a Method of Obtaining New Biological Properties of Biodegradable Materials

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