Extraction, characterization, utilization as wound dressing and drug delivery of Bletilla striata polysaccharide: A review

Chen, Ziyan; Cheng, Lizeng; He, Yichen; Wei, Xinlin

doi:10.1016/j.ijbiomac.2018.09.028

Cited by 138 publications

(63 citation statements)

References 71 publications

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“…In traditional Chinese herbal medicine, Bletilla striata (BS) is considered to be efficacious against hemostasis and inflammation and to promote tissue regeneration and bodily functions [46]. However, most of the previous studies on BSP have focused on its anti-oxidation and anti-inflammatory effects, while only a few studies have investigated its other effects.…”

Section: Discussionmentioning

confidence: 99%

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Polysaccharide Extracted from Bletilla striata Promotes Proliferation and Migration of Human Tenocytes

Chen

et al. 2020

Polymers

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Tendon healing after injury is relatively slow, mainly because of the weak activity and metabolic properties of tendon cells (tenocytes). Bletilla striata polysaccharide (BSP) has been reported to enhance cell proliferation. Here, we aimed to increase tendon cell proliferation by BSP treatment. We isolated tenocytes from the flexor tendon of human origin. Moreover, we improved the process of extracting BSP. When human tenocytes (HTs) were treated with 100 μg/mL BSP, the MEK/ERK1/2 and PI3K/Akt signaling pathways were activated, thereby enhancing the proliferation ability of tenocytes. BSP treatment also increased the migration of HTs and their ability to secrete the extracellular matrix (Col-I and Col-III). In conclusion, BSP was successfully extracted from a natural Chinese herbal extract and was shown to enhance tenocytes proliferation, migration and collagen release ability. This study is the first to demonstrate improved healing of tendons using BSP.

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Section: Discussionmentioning

confidence: 99%

“…BSP could simultaneously accelerate fibroblast (or myofibroblast) proliferation and collagen depositions during the cell proliferation period. Finally, BSP continues to induce collagen synthesis until granulation tissue formation and epithelial cell thickening are achieved [46].…”

Section: Discussionmentioning

confidence: 99%

Polysaccharide Extracted from Bletilla striata Promotes Proliferation and Migration of Human Tenocytes

Chen

et al. 2020

Polymers

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“…The length of the predicted BsIAAs ranged from 1010 bp (BsIAA27) to 4335 bp (BsIAA1), with molecular weights ranging from 88.94245 kDa to 362.22076 kDa, and the deduced isoelectric points varied widely, from 4.73 (BsIAA1&2) to 5.17 (BsIAA27). The instability index analysis found that except the proteins of BsIAA3, 4,13,16,17,26,27 were stable (unstable index < 40), the rest were unstable proteins (unstable index > 40). Subcellular localization analysis was detected to localize to the Nucleus Secondary structure analysis found that proteins of BsIAA family accounted for a large proportion of random coils, of which 26 were the largest proportion of random coils.…”

Section: Identification Of Aux/iaa Gene Families and Analysis Of Protmentioning

confidence: 99%

Identification and bioinformatic analysis of Aux/IAA family based on transcriptome data of Bletilla striata

Liu

Li³

et al. 2019

Bioengineered

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Auxin/Indole-3-Acetic Acid (Aux/IAA) genes are involved in auxin signaling pathway and play an important role in plant growth and development. However, many studies focus on Aux/IAA gene families and much less known in Bletilla striata. In this study, a total of 27 Aux/IAA genes (BsIAA1-27) were cloned from the transcriptome of Bletilla striata. Based on a phylogenetic analysis of the Aux/IAA protein sequences from B. striata, Arabidopsis thaliana and Dendrobium officinale, the Aux/IAA genes of B. striata (BsIAAs) were categorized into 2 subfamilies and 9 groups. While BsIAAs were more closer to those of D. officinale compared to A. thaliana. EST-SSR marker mining test showed that 4 markers could be stably amplified with obvious polymorphisms among 4 landraces. Our results suggested that BsIAAs were involved in the process of tuber development and provided insights into functional roles of Aux/IAA genes in B. striata and other plants.In this paper, we identified the 27 members of the Aux/IAA gene family which can be divided into 2 groups and 9 subfamilies. The similar branches of Aux/IAA proteins had the same or similar motifs, such as genes between BsIAA10 and BsIAA12, BsIAA11 and BsIAA13, BsIAA18 and BsIAA20, indicating that Aux/IAA proteins were conserved. Among them, BsIAAs were more closer to those of D. officinale compared to A. thaliana.

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“…4 Spatially and temporally controlled heterogeneity in the physicochemical properties of cell wall non-cellulosic polysaccharides is observed at the tissue and individual cell levels, which plays important role in defensing and survival of the plants. It has been found that the herb polysaccharides have important biological activities such as anti-tumor, antioxidant, anti-diabetic, radiation protecting, antiviral, hypolipidemic, immunomodulatory, and other activities [8][9][10][11][12][13][14][15][16][17][18][19] with lower toxicity and side effects. Therefore, the isolation, characterization, and biological activity testing of polysaccharides in herbs have become a hot research field in China.…”

Section: Introductionmentioning

confidence: 99%

The structures and biological functions of polysaccharides from traditional Chinese herbs

Zeng

Chen

et al. 2019

Progress in Molecular Biology and Translational Science

221

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Most of traditional Chinese medicine substances come from herbal plants. The medicinal quality of herbal plants varies with the locations of cultivation, the parts of the herb collected, the season of the herb collected, and the herb processing method. Polysaccharides are major components of the herb plants and their biosynthesis is partly controlled by the genes but mostly influenced by the availability of the nutrition and determined by the various environmental factors. In recent decades, polysaccharides isolated from different kinds of Chinese herbs have received much attention due to their important biological activities, such as anti-tumor, anti-oxidant, anti-diabetic, radiation protecting, antiviral, hypolipidemic, and immunomodulatory activities. Interestingly, different batches of the same herb can obtain different polysaccharide fractions with

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Extraction, characterization, utilization as wound dressing and drug delivery of Bletilla striata polysaccharide: A review

Cited by 138 publications

References 71 publications

Polysaccharide Extracted from Bletilla striata Promotes Proliferation and Migration of Human Tenocytes

Polysaccharide Extracted from Bletilla striata Promotes Proliferation and Migration of Human Tenocytes

Identification and bioinformatic analysis of Aux/IAA family based on transcriptome data of Bletilla striata

The structures and biological functions of polysaccharides from traditional Chinese herbs

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