Extraction and characterization of total phenolic and flavonoid contents from bark of Swietenia macrophylla and their antimicrobial and antioxidant properties

Borah, Abhinav; Selvaraj, Subbalaxmi; Holla, Sowmya; De, Shounak

doi:10.1016/j.arabjc.2022.104370

Cited by 9 publications

(4 citation statements)

References 37 publications

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“…One of the strong antioxidants herbal is S. macrophylla . Using the 1,1-diphenyl-2-picrylhydrazyl radical scavenging experiment, the antioxidant activity of S. macrophylla extract was examined, and it demonstrated a great antioxidant effect ( Yudhani et al , 2021 ; Borah et al , 2022 ; Kurnijasanti et al , 2023 ). Herbal nanotechnology can be used to increase the therapeutic value by reducing toxicity and increasing bioavailability.…”

Section: Resultsmentioning

confidence: 99%

“…The nanoparticles of S. macrophylla ethanol extract include a phenolic substance proven to be an antioxidant by scavenging free radicals. This can decrease MDA, and increase SOD and GPx is one of the possible mechanisms to protect the kidney cell damage due to the oxidative stress produced by STZ ( Borah et al , 2022 ; Kurnijasanti et al , 2023 ). Studies have indicated that limonoids, catechin, swietenine, and phenolic compounds enhance the tissue architecture of the kidneys, boost antioxidant enzyme activity, decrease lipid peroxidation, and scavenge free radicals, thereby preventing STZ-induced damage to kidney cells.…”

Section: Resultsmentioning

confidence: 99%

“…A natural substance called Swietenia macrophylla exhibits vigorous antioxidant activity and may scavenge ROS to prevent oxidative damage. Swietenia macrophylla offers pharmacological benefits such as anti-inflammatory, antifungal, antioxidant, antiviral, immunomodulatory, antibacterial, and anti-diabetic properties ( Yudhani et al , 2021 ; Borah et al , 2022 ; Kurnijasanti et al , 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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Protecting mechanism of Swietenia macrophylla ethanol extract nanoparticle on Streptozotocin induced renal damage in rat

Kurnijasanti,

Wardani,

Mustafa

et al. 2023

Open Vet J

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Background: Hyperglycemia increases Reactive Oxygen Species (ROS), which contributes to diabetic complications such as kidney cell damage. Antioxidant administration could inhibit ROS and kidney cell damage commonly seen in hyperglycemia. Aim: We want to demonstrate that the antioxidant properties of Swietenia macrophylla ethanol extract nanoparticles can prevent kidney cell damage brought on by streptozotozine (STZ) in the current investigation. Methods: This study employs high-energy ball milling to produce nanoparticles from Swietenia macrophylla extract. Additionally, dynamic light scattering (DLS) is utilized to characterize the nanoparticle sizes of the Swietenia macrophylla ethanol extract. Five groups, each consisting of eight rats, were formed from 40 animals. Control rats received distilled water, the diabetic rats were administered streptozotocin (STZ) injections, while Swietenia macrophylla rats were given Swietenia macrophylla extract nanoparticles orally and streptozotocin (STZ) injection. After the trial, blood from a rat was drawn intracardially to check the levels of blood urea nitrogen (BUN) and creatinine. The levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA) were then assessed in kidney tissue samples. Histological alterations were evaluated in kidney section samples. Results: A Dynamic Light Scattering (DLS) analysis estimated the size of the Swietenia macrophylla ethanol extract nanoparticles to be about 91.50 ± 23.06 nm. BUN and creatinine levels were significantly raised after STZ treatment. STZ significantly decreased SOD and GPx levels in kidney tissue while raising MDA levels (p< 0.05). Swietenia macrophylla ethanol extract nanoparticle caused the increased levels of BUN and Creatinine in blood to normal levels (P<0.05), indicating that Swietenia macrophylla ethanol extract prevented the STZ-induced liver cell damage. Additionally, Swietenia macrophylla nanoparticles significantly raise GPx and SOD levels in kidney tissue while lowering MDA levels (p < 0.05). These actions are thought to have prevented kidney histological alterations (degeneration and necrosis) in diabetic rats. Conclusion: According to these results, the anti-oxidative stress properties of Swietenia macrophylla nanoparticles make them potentially effective nephroprotective therapies for STZ-induced kidney cell damage.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protecting mechanism of Swietenia macrophylla ethanol extract nanoparticle on Streptozotocin induced renal damage in rat

Kurnijasanti,

Wardani,

Mustafa

et al. 2023

Open Vet J

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“…S. macrophylla has become of great interest and has been used as a traditional treatment against diabetes and its complications. Moreover, the hypoglycemic and antioxidant activities of S. macrophylla are supported by evidence from experimental studies [ 14 , 15 ]. Herbal medicine antioxidants are widely used as an alternative exogenous antioxidant to protect cardiac cells in diabetic rats [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 91%

Protective Mechanism Pathway of Swietenia macrophylla Extract Nanoparticles against Cardiac Cell Damage in Diabetic Rats

2023

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Hyperglycemia causes cardiac cell damage through increasing ROS production during diabetic complications. The current study proves the antioxidant activity of Swietenia macrophylla (S. macrophylla) extract nanoparticles as a protector against streptozotocin (STZ)-induced cardiac cell damage. In this research, high-energy ball milling is used to create S. macrophylla extract nanoparticles. The active chemical compounds in the S. macrophylla extract nanoparticles were analyzed through phytochemical screening and GC-MS. Furthermore, we characterized the size of S. macrophylla extract nanoparticles with Dynamic Light Scattering (DLS). Forty male rats were divided randomly into five groups. In the control group, rats received aqua dest orally; in the diabetic group, rats were injected intraperitoneally with STZ; in the S. macrophylla group, rats were injected with STZ and orally given S. macrophylla extract nanoparticles. The results of phytochemical screening showed that S. macrophylla extract nanoparticles contain saponins, flavonoids, alkaloids, phenolics and tannins. Seven chemical compounds in S. macrophylla extract nanoparticles were identified using GC-MS, including phenol, piperidine, imidazole, hexadecene, heptadecanol, dihexylsulfide and heptanol. DLS showed that the S. macrophylla extract nanoparticles’ size was 91.50 ± 23.06 nm. Injection with STZ significantly increased malondialdehyde (MDA) levels in cardiac tissue and creatine kinase–myocardial band (CK-MB) and lactate dehydrogenase (LDH) levels in serum. STZ also significantly reduced the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and the level of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in cardiac tissue compared with the control group (p < 0.05). In contrast, the administration of S. macrophylla extract nanoparticles can prevent STZ-induced cardiac cell damage through decreasing the level of CK-MB and LDH in serum and the level of MDA in cardiac tissue. S. macrophylla extract nanoparticles also significantly increased Nrf2 expression as well as SOD and GPx levels in cardiac tissue. These effects are related to the prevention of cardiac histopathological alteration (degeneration and necrosis) in diabetic rats. These results suggest that S. macrophylla nanoparticles contain active compounds such as flavonoids, phenols, piperidine, imidazole and hexadecene and have strong antioxidant activity. These can act as a potential cardioprotective agent against STZ-induced cardiac cell damage due to its antioxidant properties.

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Fermentation of Persimmon Leaves Extract by Lactiplantibacillus plantarum and Saccharomyces cerevisiae

Tian,

Ma,

Yang

et al. 2023

Mol Biotechnol

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Extraction and characterization of total phenolic and flavonoid contents from bark of Swietenia macrophylla and their antimicrobial and antioxidant properties

Cited by 9 publications

References 37 publications

Protecting mechanism of Swietenia macrophylla ethanol extract nanoparticle on Streptozotocin induced renal damage in rat

Protecting mechanism of Swietenia macrophylla ethanol extract nanoparticle on Streptozotocin induced renal damage in rat

Protective Mechanism Pathway of Swietenia macrophylla Extract Nanoparticles against Cardiac Cell Damage in Diabetic Rats

Fermentation of Persimmon Leaves Extract by Lactiplantibacillus plantarum and Saccharomyces cerevisiae

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