Extract of the Bark of Bathysa cuspidataAttenuates the Development of Chemically-Induced Preneoplastic Colorectal Lesions in Rats

Rosa, Damiana Diniz; Reis, Sandra Aparecida dos; Siqueira, Nathane Pais; Gonçalves, Reggiani Vilela; Machado, Alessandra Barbosa Ferreira; Tafuri, N.F.; Leite, João Paulo Viana; Matta, Sérgio Luís Pinto da; Pelúzio, Maria do Carmo Gouveia

doi:10.1590/s1516-89132015050228

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Although no increase in the expression of pro-apoptotic genes was observed in this study, Treatment IV decreased ACF and the expression of the IL-1 gene, a proinflammatory cytokine, which demonstrates that the presence of PUFAs may also have contributed to the colon protection of animals. Similar data were observed by (Rosa et al, 2015) who induced ACF in the colon of rats fed normal lipid diets plus 4% olive, fish, flaxseed or soy oil (control). In the proximal portion of the colon, lower levels of ACF were found in the fish and linseed oil groups.…”

Section: Gene Expressionsupporting

confidence: 84%

“…DMH is a drug widely used to induce ACF in rodents. These ACF can be distributed in different portions of the proximal, medial or distal colon, depending on the type of study (Gomides et al, 2015(Gomides et al, , 2014Marcon et al, 2020;Reis et al, 2019;Rosa et al, 2015). In this study, there was a lower prevalence of ACF in the proximal colon of animals in Treatment IV (Table 2).…”

Section: Aberrant Crypt Foci Countmentioning

confidence: 54%

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Butia capitata (sour coconut) prevents the appearance of Aberrant Crypt Foci in the colon of rats

Gomides¹,

Santos²,

Barbosa³

et al. 2022

NRFHH

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Colorectal cancer is a life-threatening disease. This study evaluates whether sour coconut (Butia capitata) prevents the appearance of aberrant crypt foci (ACF) in the colon of rats, induced with 1,2-dimethylhydrazine (DMH). The test subjects were divided into four treatment groups: I - Control; II - aqueous extract of sour coconut pulp; III - DMH and IV - Aqueous extract of sour coconut pulp + DMH. The colons of the subjects were submitted to ACF count, analysis of gene expression and histopathological. The count of ACF differed in the proximal portion of the colon between animals treated III and IV, with a lower count in Treatment IV (p <0.05). The interleukin-1 (IL-1) gene (p <0.05) was less expressed in Treatment IV. In the histopalogic analysis of the colons in Treatment IV, less dilation was observed at the base of the crypts and the lumen was moderately dilated. The sour coconut acted in preventing the appearance of ACF, probably due to its high composition in bioactive compounds, such as phenolic compounds, polyunsaturated fatty acids and vitamin E. The anti-inflammatory capacity reduces the expression of the IL-1 gene and preserves the histo-architecture of the colon.

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Section: Gene Expressionsupporting

confidence: 84%

Section: Aberrant Crypt Foci Countmentioning

confidence: 54%