Extract of&lt;b&gt;&lt;i&gt; Helicobacter pylori&lt;/i&gt;&lt;/b&gt; Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure

Wijck, Yolanda van; John-Schuster, Gerrit; Schadewijk, Annemarie van; Oever, Ruben L van den; Obieglo, Katja; Hiemstra, Pieter S.; Müller, Anne; Smits, Hermelijn H.; Taube, Christian

doi:10.1159/000500598

Cited by 14 publications

(13 citation statements)

References 23 publications

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“…An experimental study demonstrated that oral immunomodulators with a H. pylori extract prevented airway hyperresponsiveness, bronchoalveolar eosinophilia, pulmonary inflammation and Th2 cytokine production, which are hallmarks of allergen-induced asthma, in mice (44). Similar results were also obtained in a recent study (45). Furthermore, several large cross-sectional and case-control studies demonstrated an inverse association between a H. pylori positive state and allergic diseases, including inflammatory airway diseases (44).…”

Section: Fev1 Fvc Vcmax ---------------------------------------------supporting

confidence: 71%

“…A meta-analysis demonstrated that a H. pylori positive state was associated with an estimated 18% reduction in the risk of atopy, as estimated by allergen skin tests and specific IgE (41). Whether a H. pylori positive state is inversely associated with allergic diseases remains controversial (42)(43)(44)(45). An experimental study demonstrated that oral immunomodulators with a H. pylori extract prevented airway hyperresponsiveness, bronchoalveolar eosinophilia, pulmonary inflammation and Th2 cytokine production, which are hallmarks of allergen-induced asthma, in mice (44).…”

Section: Fev1 Fvc Vcmax ---------------------------------------------mentioning

confidence: 99%

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Helicobacter pylori is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough

Zheng

A-huo

et al. 2020

Exp Ther Med

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The present study aimed to investigate the potential association between Helicobacter pylori (a H. pylori) positive state and chronic cough. A clinical observational study with systematic analysis was performed, including 278 patients with complaints of chronic cough and 148 healthy controls. a H. pylori positive state was present in 61.2% of the patients in the chronic cough group and 68.9% in the chronic refractory cough group, as opposed to 43.9% in the control group. There was a significant improvement in 65.5% of the patients with chronic refractory cough following successful a H. pylori eradication therapy. In addition, patients with chronic cough exposed to a H. pylori exhibited decreased pulmonary function with a decrease in forced expiratory volume in 1 sec by 84 ml, a decrease in the forced vital capacity by 53 ml and a decrease in maximal vital capacity by 46 ml. The difference was even more obvious in the chronic refractory cough group. The allergy status differed significantly according to age between a H. pylori-positive and-negative cases in the cough variant asthma and allergic cough groups. Among patients aged <40 years, a H. pylori-positive cases had a lower prevalence of atopy and lower total serum immunoglobin E levels compared with a H. pylori-negative cases. However, there was no significant association between a H. pylori status and C-reactive protein levels, erythrocyte sedimentation rate or eosinophil count in the peripheral blood. In conclusion, the present study demonstrated that a H. pylori infection may be a factor associated with chronic cough and it may be associated with a decline in pulmonary function and reduced incidence of allergic conditions. Thus, a H. pylori may represent a target for the treatment of chronic cough.

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Section: Fev1 Fvc Vcmax ---------------------------------------------supporting

confidence: 71%

Section: Fev1 Fvc Vcmax ---------------------------------------------mentioning

confidence: 99%

Helicobacter pylori is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough

Zheng

A-huo

et al. 2020

Exp Ther Med

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“…96 Moreover, H pylori extract was also able to decrease mucus production and inflammation in mice challenged with house dust mites. 97…”

Section: Allergic Disordersmentioning

confidence: 99%

Review: Extragastric diseases andHelicobacter pylori

et al. 2020

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The involvement of Helicobacter pylori infection in many extra‐gastroduodenal manifestations remains a fascinating field of investigation. However, for several of these supposed associations, the potential pathogenic mechanism remains unclear. The present review highlights the main associations of H pylori with extra‐gastroduodenal manifestations reported during the last year. We searched for the most relevant studies on this topic, published between April 2019 and March 2020, identified using the term “Helicobacter” in the MEDLINE/Pubmed database. Consistent data emerged from studies investigating metabolic syndrome and ischaemic cardiovascular diseases. Other reported fields of investigation were hepatology, especially focused on non‐alcoholic steatohepatitis, neurology, including Parkinson’s disease and Alzheimer’s disease, as well as dermatology. Inflammatory bowel disease (IBD), that comprises Crohn’s disease and ulcerative colitis, may originate from a dysregulation of the host’s immune response to commensal bacteria in individuals with genetic predisposition. The reduction of biodiversity and other specific imbalances in the faecal microbiome composition of IBD patients compared to that of healthy controls support this hypothesis. In this context, an inverse correlation between H pylori infection and IBD prevalence has been confirmed. Similar results were found in patients with kidney diseases and allergic manifestations. There are indications of the possible involvement of H pylori infection in metabolic syndrome and ischaemic cardiovascular diseases. However, due to a series of factors linked to study designs and the multifactorial pathogenesis of some diseases, further studies are needed.

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“…Since HP-NAP is considered as a possible regulator for Tregs and can inhibit allergic inflammation of asthma, it is possible to develop HP-NAP as an efficient H. pylorispecific vaccine to treat allergic asthma [78,145,146]. van Wijck et al [147] have shown that H. pylori extract can effectively reduce the production of mucus and multiple characteristics of inflammation in the mice rechallenged by house dust mite. VacA and GGT, 2 persistence determinants in H. pylori, are sufficient in preventing asthma and could be given in their purified forms for treatment [148].…”

Section: Treatment Of Asthma Related To H Pylori Infectionmentioning

confidence: 99%

The Protective Effects of Helicobacter pylori Infection on Allergic Asthma

Zuo¹,

Yue²,

Sun³

et al. 2020

Int Arch Allergy Immunol

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As an ancient Gram-negative bacterium, Helicobacter pylori has settled in human stomach. Eradicating H. pylori increases the morbidities of asthma and other allergic diseases. Therefore, H. pylori might play a protective role against asthma. The “disappearing microbiota” hypothesis suggests that the absence of certain types of the ancestral microbiota could change the development of immunology, metabolism, and cognitive ability in our early life, contributing to the development of some diseases. And the Hygiene Hypothesis links early environmental and microbial exposure to the prevalence of atopic allergies and asthma. Exposure to the environment and microbes can influence the growing immune system and protect subsequent immune-mediated diseases. H. pylori can inhibit allergic asthma by regulating the ratio of helper T cells 1/2 (Th1/Th2), Th17/regulatory T cells (Tregs), etc. H. pylori can also target dendritic cells to promote immune tolerance and enhance the protective effect on allergic asthma, and this effect relies on highly suppressed Tregs. The remote regulation of lung immune function by H. pylori is consistent with the gut-lung axis theory. Perhaps, H. pylori also protects against asthma by altering levels of stomach hormones, affecting the autonomic nervous system and lowering the expression of heat shock protein 70. Therapeutic products from H. pylori may be used to prevent and treat asthma. This paper reviews the possible protective influence of H. pylori on allergic asthma and the possible application of H. pylori in treating asthma.

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Extract of<b><i> Helicobacter pylori</i></b> Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure

Cited by 14 publications

References 23 publications

<em>Helicobacter pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough

<em>Helicobacter pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough

Review: Extragastric diseases andHelicobacter pylori

The Protective Effects of <b><i>Helicobacter pylori</i></b> Infection on Allergic Asthma

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Extract of<b><i> Helicobacter pylori</i></b> Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure

Cited by 14 publications

References 23 publications

<em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough

<em>Helicobacter&nbsp;pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough

Review: Extragastric diseases andHelicobacter pylori

The Protective Effects of <b><i>Helicobacter pylori</i></b> Infection on Allergic Asthma

Contact Info

Product

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<em>Helicobacter pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough

<em>Helicobacter pylori</em> is associated with weakened pulmonary function and reduced incidence of allergic conditions in patients with chronic cough