Extracellular Nucleic Acids in Maternal Circulation as Potential Biomarkers for Placental Insufficiency

Hromadníková, Ilona

doi:10.1089/dna.2011.1530

Cited by 30 publications

(33 citation statements)

References 88 publications

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“…Due to placental continuous remodeling, these extracellular nucleic acids may be detected in maternal blood during the course of gestation and can be measured to monitor placental function and allow early diagnosis of pregnancy complications [20–23]. For these motivations in recent years there has been a trend to develop noninvasive methods for the detection in maternal circulation of cell-free nucleic acids, including miRNAs coming from the embryo-placental compartment [24–43].…”

Section: Resultsmentioning

confidence: 99%

Do miRNAs Play a Role in Fetal Growth Restriction? A Fresh Look to a Busy Corner

Chiofalo

Laganà

Vaiarelli

et al. 2017

BioMed Research International

107

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Placenta is the crucial organ for embryo and fetus development and plays a critical role in the development of fetal growth restriction (FGR). There are increasing evidences on the role of microRNAs (miRNAs) in a variety of pregnancy-related complications such as preeclampsia and FGR. More than 1880 miRNAs have been reported in humans and most of them are expressed in placenta. In this paper, we aimed to review the current evidence about the topic. According to retrieved data, controversial results about placental expression of miRNAs could be due (at least in part) to the different experimental methods used by different groups. Despite the fact that several authors have demonstrated a relatively easy and feasible detection of some miRNAs in maternal whole peripheral blood, costs of these tests should be reduced in order to increase cohorts and have stronger evidence. In this regard, we take the opportunity to solicit future studies on large cohort and adequate statistical power, in order to identify a panel of biomarkers on maternal peripheral blood for early diagnosis of FGR.

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Section: Resultsmentioning

confidence: 99%

Do miRNAs Play a Role in Fetal Growth Restriction? A Fresh Look to a Busy Corner

Chiofalo

Laganà

Vaiarelli

et al. 2017

BioMed Research International

107

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“…In this study, we focused on the examination of microRNA levels in a specific area, that is, in the central cotyledon zone, where the umbilical cord is inserted into the chorionic plate. However, the placenta is being continuously remodeled during normal placental development, and extracellular nucleic acids of both fetal and placental origin, packed into either trophoblast-derived apoptotic bodies or shedding syncytiotrophoblast micro-particles, may be detected in maternal circulation during the course of normal gestation (Nelson, 1996;Oudejans et al, 2003;Huppertz and Kingdom, 2004;Orozco et al, 2006;Hromadnikova, 2012). It is obvious that the levels of circulating nucleic acids, mainly the levels of circulating placental-specific C19MC microRNAs, present in maternal circulation during gestation reflect the overall status of the placenta.…”

Section: Mcl1mentioning

confidence: 99%

Expression Profile of C19MC microRNAs in Placental Tissue in Pregnancy-Related Complications

Hromadníková

Kotlabova

Ondráčková

et al. 2015

DNA and Cell Biology

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106

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“…In a study by Murphy et al [65] in 2015, circulating miRNA profiles were identified at the time of delivery and at 1 year postpartum in PE and control groups by quantitative reverse transcription-PCR, and seven maternal plasma miRNAs (miR-98, miR-222, miR-210, miR-155, miR-296, miR-181a, and miR-29b) were increased in women with severe PE. Recent studies of placenta-specific miRNAs in the maternal circulation also indicated their potential as predictive markers of placental insufficiency [66][67][68][69].…”

Section: Cell-free Dnamentioning

confidence: 99%

Biomarkers and genetic factors for early prediction of pre-eclampsia

Kim

Shim

2017

J Genet Med

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JGMof the main causes of poor placental perfusion and leads to placental and fetal hypoxia. Hypoxia is a potent stimulus for release of the numerous factors into the maternal circulation that may affect endothelial function of maternal system, and this can be reason of hypertension and other signs of the disease.Currently, PE is thought to result from defective spiral artery remodeling, leading to cellular ischemia in the placenta and resulting widespread endothelial dysfunction of maternal multiorgan systems. Exact etiology underlying the cellular and molecular mechanisms of PE is still elusive. But recent observations support that altered expression of multiple factors is responsible for the clinical manifestation of the disease [4].PE is divided to 2 types; early-onset and late-onset PE. Earlyonset PE typically requires early delivery (before 34 weeks' gestation) as intrauterine growth retardation, unusual uterine and umbilical artery Doppler waveforms, and negative effects on the maternal and neonatal sides are common. Late-onset PE is commonly related to mild maternal disease and a low rate of

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Extracellular Nucleic Acids in Maternal Circulation as Potential Biomarkers for Placental Insufficiency

Cited by 30 publications

References 88 publications

Do miRNAs Play a Role in Fetal Growth Restriction? A Fresh Look to a Busy Corner

Do miRNAs Play a Role in Fetal Growth Restriction? A Fresh Look to a Busy Corner

Expression Profile of C19MC microRNAs in Placental Tissue in Pregnancy-Related Complications

Biomarkers and genetic factors for early prediction of pre-eclampsia

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