Extracellular dopamine dynamics in rat caudate–putamen during experimenter-delivered and intracranial self-stimulation

Kilpatrick, Michaux; Rooney, Martina; Michael, D.J; Wightman, R. Mark

doi:10.1016/s0306-4522(99)00578-3

Cited by 69 publications

(66 citation statements)

References 65 publications

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“…These findings inspired a fixed amplitude model of dopamine release (Wightman et al, 1988) that was used to fit dopamine release data provided that stimulation frequencies remained extremely low. However, more recent work using less intense, but more rapidly repeated electrical stimuli, shows that rich, dynamic fluctuations occur in response to intracranial self-stimulation (Garris et al, 1999;Yavich and Tiihonen, 2000) or experimenter-delivered stimuli in vivo (Kilpatrick et al, 2000;Yavich and MacDonald, 2000) and in vitro (Cragg, 2003). Collectively, these observations suggested the hypothesis that multiple dynamic components modulate dopamine delivery, thus contradicting fixed-amplitude models of release (Wightman et al, 1988).…”

Section: Introductionmentioning

confidence: 42%

“…1 A) (see also Robinson et al, 2002). The irregular patterns of stimulation were the recorded lever-press records of other animals during selfstimulation experiments (patterns taken from self-stimulation experiments described in Kilpatrick et al, 2000). As shown in Figure 1B, the richness of the dynamic influences on dopamine release is apparent for an irregular stimulation pattern in which both facilitation (arrow 2) and depression (arrow 3) of release, compared with the initial event (arrow 1), are evident.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Dynamic Gain Control of Dopamine Delivery in Freely Moving Animals

Montague¹,

McClure²,

Baldwin³

et al. 2004

J. Neurosci.

157

151

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Activity changes in a large subset of midbrain dopamine neurons fulfill numerous assumptions of learning theory by encoding a prediction error between actual and predicted reward. This computational interpretation of dopaminergic spike activity invites the important question of how changes in spike rate are translated into changes in dopamine delivery at target neural structures. Using electrochemical detection of rapid dopamine release in the striatum of freely moving rats, we established that a single dynamic model can capture all the measured fluctuations in dopamine delivery. This model revealed three independent short-term adaptive processes acting to control dopamine release. These short-term components generalized well across animals and stimulation patterns and were preserved under anesthesia. The model has implications for the dynamic filtering interposed between changes in spike production and forebrain dopamine release.

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Section: Introductionmentioning

confidence: 42%

Section: Resultsmentioning

confidence: 99%

Dynamic Gain Control of Dopamine Delivery in Freely Moving Animals

Montague¹,

McClure²,

Baldwin³

et al. 2004

J. Neurosci.

157

151

View full text Add to dashboard Cite

show abstract

“…However, measurements of dopamine release during ICS indicate that it is not a necessary condition for ICS (35). Indeed, with a continuous ICS schedule, dopamine release is suppressed (28,36,37). Although direct activation of dopaminergic neurons is unnecessary for ICS (20), we purposely used stimulation parameters that orthodromically activate dopaminergic neurons (15).…”

Section: Discussionmentioning

confidence: 99%

Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: Implications for intracranial self-stimulation

Cheer

Heien²,

Garris

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

124

128

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Intracranial self-stimulation (ICS) is a motivated behavior that results from contingent activation of the brain reward system. ICS with stimulating electrodes placed in the medial forebrain bundle (MFB) is particularly robust. However, the neurons that course through this pathway use a variety of neurotransmitters including dopamine and GABA. For this reason, the neurotransmitters that are central to this behavior, and the specific roles that they subserve, remain unclear. Here, we used extracellular electrophysiology and cyclic voltammetry at the same electrode in awake rats to simultaneously examine cell firing and dopamine release in the nucleus accumbens (NAc) during ICS and noncontingent stimulation of the MFB. ICS elicited dopamine release in the NAc and produced coincident time-locked changes (predominantly inhibitions) in the activity of a subset of NAc neurons. Similar responses were elicited with noncontingent stimulations. The changes in firing rate induced by noncontingent stimulations were reversed by the GABAA receptor antagonist bicuculline. Most time-locked unit activity was unaffected by D1 or D2-like dopamine-receptor antagonists, or by inhibition of evoked dopamine release, although, for a minority of units, the D1 dopamine-receptor antagonist SCH23390 attenuated neural activity. Thus, neurons in the NAc are preferentially inhibited by GABAA receptors after MFB stimulation, a mechanism that may also be important in ICS.cyclic voltammetry ͉ electrophysiology ͉ nucleus accumbens ͉ motivated behavior ͉ behaving rat

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“…7 (bipolar, 24 pulses, 60 Hz, 120 A) is also reinforcing to the rat because it will self-administer such stimulation trains in the substantia nigra and ventral tegmental area in the intracranial self-stimulation (ICS) paradigm. In a particularly interesting series of experiments, the differences in dopamine release produced by experimenter-administered vs self-administered stimulation are described (55,56 ). When the experimenter administered a single stimulation, dopamine release was evident in the caudateputamen and nucleus accumbens core and shell.…”

Section: Electrically Stimulated Dopamine Releasementioning

confidence: 99%