Extra virgin olive oil consumption reduces the risk of osteoporotic fractures in the PREDIMED trial

García‐Gavilán, Jesús; Bulló, Mònica; Canudas, Sı́lvia; Martínez‐González, Miguel Ángel; Estruch, Ramón; Giardina, S; Fitó, Montserrat; Corella, Dolores; Ros, Emilio; Salas‐Salvadó, Jordi

doi:10.1016/j.clnu.2016.12.030

Cited by 50 publications

(29 citation statements)

References 37 publications

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“…Furthermore, it was associated with a higher total osteocalcin concentration and an increase in procollagen I N-terminal propeptide in a group of men, suggesting the protective effects of olive oil on bone [74]. A cohort of subjects was analyzed as part of the PREDIMED study, and those participants with the highest intake of extra-virgin olive oil had the lowest risk of osteoporosis-related fractures [75].…”

Section: Mediterranean Dietmentioning

confidence: 99%

Nutrients and Dietary Patterns Related to Osteoporosis

2020

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Osteoporosis is a common chronic disease characterized by a decrease in bone mineral density, impaired bone strength, and an increased risk of fragility fractures. Fragility fractures are associated with significant morbidity, mortality and disability and are a major public health problem worldwide. The influence of nutritional factors on the development and progression of this disease can be significant and is not yet well established. Calcium intake and vitamin D status are considered to be essential for bone metabolism homeostasis. However, some recent studies have questioned the usefulness of calcium and vitamin D supplements in decreasing the risk of fractures. The adequate intake of protein, vegetables and other nutrients is also of interest, and recommendations have been established by expert consensus and clinical practice guidelines. It is important to understand the influence of nutrients not only in isolation but also in the context of a dietary pattern, which is a complex mixture of nutrients. In this review, we evaluate the available scientific evidence for the effects of the main dietary patterns on bone health. Although some dietary patterns seem to have beneficial effects, more studies are needed to fully elucidate the true influence of diet on bone fragility.

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Section: Mediterranean Dietmentioning

confidence: 99%

Nutrients and Dietary Patterns Related to Osteoporosis

2020

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“…We believe that this small reduction in protein intake will not affect BMD due to the positive effects of olive oil. A recent study showed that elderly participants in the highest tertile of EVOO consumption had a 51% lower risk of fracture [14].…”

Section: Discussionmentioning

confidence: 99%

“…These conditions may support osteoclast hyperactivity, followed by osteoblast hypoactivity, resulting in bone deterioration [5,6,8,9]. Dietary interventions to stabilize and/or reverse bone mass loss, such as the use of extra virgin olive oil, were examined [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Extra Virgin Olive Oil and Traditional Brazilian Diet on the Bone Health Parameters of Severely Obese Adults: A Randomized Controlled Trial

et al. 2020

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Dietary interventions can stabilize and/or reverse bone mass loss. However, there are no reports on its effects on bone mineral density (BMD) in severely obese people, despite the vulnerability of this group to bone loss. We examine the effect of extra virgin olive oil supplementation and the traditional Brazilian diet (DieTBra) on BMD and levels of calcium, vitamin D, and parathyroid hormone (PTH) in severely obese adults. A randomized controlled trial followed-up with severely obese adults (n = 111, with mean body mass index 43.6 kg/m2 ± 4.5 kg/m2) for 12 weeks. Study participants received either olive oil (52 mL/day), DieTBra, or olive oil + DieTBra (52 mL/day + DieTBra). BMD was assessed by total spine and hip dual-energy X-ray absorptiometry. After interventions, BMD means for total spine (p = 0.016) and total hip (p = 0.029) were higher in the DieTBra group than in the olive oil + DieTBra group. Final mean calcium levels were higher in the olive oil group compared to the olive oil + DieTBra group (p = 0.026). Findings suggest that DieTBra and extra virgin olive oil have positive effects on bone health in severely obese adults. The major study was registered at ClinicalTrials.gov (NCT02463435).

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“…Nowadays, the interest of scientific community toward these phytochemicals is much more increasing, in light of their potential strong clinical impact [5][6][7][8], even if the bioavailability aspect has to be strongly taken into account. In fact, bioavailability is an important factor when talking about polyphenols' actions, and this is because it is affected by different environmental, host and food processing-related elements, as well as the chemical structure itself [9].…”

Section: Introductionmentioning

confidence: 99%

Potentials of Polyphenols in Bone-Implant Devices

Torre¹,

Iviglia²,

Cassinelli³

et al. 2018

Polyphenols

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Knowledge of bioactive plant-derived polyphenols is growing to such an extent that science interest is looking at development of different applications in regenerative medicine through new and state-of-the-art tissue engineering technologies. Due to their well-established and demonstrated antioxidant and anti-inflammatory beneficial properties, polyphenols have been extensively investigated to the extent that they provide benefits to different pathological conditions, including cardiovascular and bone diseases, neurodegenerative disorders, and cancer. By taking into account the main molecular pathways of polyphenols' action, we want to focus this chapter on applications of polyphenols in boneimplant devices. In particular, results of polyphenols' effects on bone cells and tissues following local delivery from innovative biomaterials will be discussed, together with preliminary in vivo tests. Purpose of the dissertation is to provide the reader new insights into knowledge of polyphenols not only regarding the different molecular mechanisms involved in their action but also the biological responses deriving from local applications.

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Extra virgin olive oil consumption reduces the risk of osteoporotic fractures in the PREDIMED trial

Cited by 50 publications

References 37 publications

Nutrients and Dietary Patterns Related to Osteoporosis

Nutrients and Dietary Patterns Related to Osteoporosis

Effect of Extra Virgin Olive Oil and Traditional Brazilian Diet on the Bone Health Parameters of Severely Obese Adults: A Randomized Controlled Trial

Potentials of Polyphenols in Bone-Implant Devices

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