2016
DOI: 10.4103/1817-1745.199477
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Extra-axial medulloblastoma in the cerebellopontine angle: Report of a rare entity with review of literature

Abstract: With only 33 cases reported so far, a purely extra-axial position of medulloblastoma at cerebellopontine (CP) angle is quite exceptional. We report a case of extra-axial medulloblastoma in a 15-year-old male child located in the CP angle that was surgically treated with a provisional diagnosis of schwannoma. Histopathological diagnosis of medulloblastoma was made with the routine hematoxylin and eosin stain and immunohistochemical markers. This case report highlights the fact that although extremely rare, the … Show more

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Cited by 12 publications
(19 citation statements)
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References 8 publications
(9 reference statements)
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“…However, some characteristics of posterior fossa tumors such as progressive cerebellar signs and gait ataxia may be seen, although usually favoring an intra-axial location. Headache, nausea, and vomiting are less distinguishable symptoms commonly reported in medulloblastoma cases [17] . Additional differential diagnoses, such as posterior fossa epidermoid cyst, hemangioblastoma, pilocytic astrocytoma, and atypical tertoid-rhabdoid tumor, may also be included.…”
Section: Discussionmentioning
confidence: 91%
See 1 more Smart Citation
“…However, some characteristics of posterior fossa tumors such as progressive cerebellar signs and gait ataxia may be seen, although usually favoring an intra-axial location. Headache, nausea, and vomiting are less distinguishable symptoms commonly reported in medulloblastoma cases [17] . Additional differential diagnoses, such as posterior fossa epidermoid cyst, hemangioblastoma, pilocytic astrocytoma, and atypical tertoid-rhabdoid tumor, may also be included.…”
Section: Discussionmentioning
confidence: 91%
“…reported a study of 129 histologically verified tumors of the posterior fossa and determined that medulloblastoma frequently exhibits increased density compared with adjacent cerebellum and can be diagnosed with high likelihood when there is a central mass exhibiting well-demarcated borders [14] . Only 35 cases of medulloblastoma have been reported to be extra-axial in nature, most of which occur in the cerebellopontine angle [15] , [16] , [17] . The extra-axial finding alongside a purely hemispheric presentation of the tumor makes our patient's case quite rare in the pediatric population.…”
Section: Discussionmentioning
confidence: 99%
“…It has been suggested that extra-axial MBs located at CPA may originate either by the proliferating remnants of the external granular layers of the cerebellar hemispheres including the flocculus or from germinal cells or their remnants present at the posterior medullary velum. [ 8 ] Akay et al . suggested that extra-axial MBs at CPA arise by the lateral extension from the fourth ventricle through the foramen of Luschka or there may be direct exophytic growth from the site of origin at the surface of cerebellum or pons.…”
Section: Discussionmentioning
confidence: 99%
“…suggested that extra-axial MBs at CPA arise by the lateral extension from the fourth ventricle through the foramen of Luschka or there may be direct exophytic growth from the site of origin at the surface of cerebellum or pons. [ 8 9 ]…”
Section: Discussionmentioning
confidence: 99%
“…Disease dissemination is an early event in MB, with up to ∼40% of patients showing metastases at diagnosis, with poor survival. Metastatic disease and tumor recurrence are responsible for the low survival rates, and those who survive frequently show treatment-related adverse effects (5,20,35,36,38,40,(50)(51)(52)(53).…”
Section: Discussionmentioning
confidence: 99%