Extra-Abdominal Desmoid Arising From a Capsule Around a Silicone Breast Implant

Jewett, Stiles T.; Mead, Jay H.

doi:10.1097/00006534-197904000-00031

Cited by 48 publications

(29 citation statements)

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“…In un nostro caso (caso n. 4), la fibromatosi insorgeva nella stessa sede di pregressa exeresi di un lipoma intrammario. Sebbene sia noto che le fibromatosi possano originare come lesioni reattive in seguito a traumi o interventi chirurgici [1], soltanto in 11 casi di FM (incluso il nostro) è stato possibile correlare l'insorgenza della patologia con un pregresso trauma mammario [3,6,12,[32][33][34][35][36]; ciò evidentemente suggerisce come la FM possa insorgere indipendentemente da traumi meccanici, i quali, come ampiamente noto, in questa sede sono per lo più responsabili di focolai di citosteatonecrosi e/o di fibrosi di tipo cicatriziale.…”

Section: Discussioneunclassified

Fibromatosis of the breast: a clinical, radiological and pathological study of a series of six cases

Magro

Gurrera²,

Scavo³

et al. 2002

Pathologica

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We describe the clinical, radiological and pathological features of a series of six cases of primary fibromatosis of the breast. Most patients (5 of 6) were women of 22-58 years of age; one case occurred in a 47-year-old man. The fibromatosis of the breast in all cases presented as a monolateral solid nodule, clinically suspicious for malignancy and in three cases was also associated with cutaneous and/or nipple retraction. None of the patients was affected by any genetic disorder characterized by fibromatoses involving multiple sites, including breast. Both echographic and mammographic examinations revealed solid masses with irregular margins but without calcifications, mimicking scirrhous carcinoma. All cases were surgically treated by lumpectomy (4 of 6) or quadrantectomy (2 of 6), and after a follow-up period ranging from 5 months to 13 years all patients are well and disease-free. Histological examination revealed finger-like infiltrating margins entrapping adjacent breast parenchyma and adipose tissue in all cases. The hallmark of the lesion was the presence of bland-looking spindle cells, with a low mitotic index, organized in long sweeping and intersecting fascicles. Three different morphological phases (i.e. proliferative, involutional and residual), identical to those observed in Dupuytren's superficial fibromatosis, variably coexisted in each case. At immunohistochemistry the cells which comprised the lesion exhibited a diffuse expression of vimentin and a heterogeneous immunoreactivity to a-smooth muscle actin, thus confirming their fibro-myofibroblastic nature. No expression of estrogen, progesterone or androgen receptors or of pS2 correlated-estrogen protein was observed. We discuss both the pathogenesis of the mammary fibromatosis, pointing to the fibroblastic cells of the mammary stroma as the putative precursors, and the differential diagnosis versus the bland-looking, monomorphic spindle cell tumor-like or tumorous lesions of the breast.

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Section: Discussioneunclassified

Fibromatosis of the breast: a clinical, radiological and pathological study of a series of six cases

Magro

Gurrera²,

Scavo³

et al. 2002

Pathologica

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“…Most are fibromatoses [1][2][3][4][5][6][7][8][9][10][11], and the remaining cases are sarcomas of various types, including stromal sarcoma, angiosarcoma, fibrosarcoma, and malignant fibrous histiocytoma [12][13][14][15][16]. To date, there has been no systematic analysis of these lesions using current diagnostic criteria to determine if the tumors can be linked to implant type or rupture and whether the balance of evidence supports a fortuitous or causal association-a debate that has potential litigious implications.…”

Section: Introductionmentioning

confidence: 99%

Do biomaterials cause implant-associated mesenchymal tumors of the breast? Analysis of 8 new cases and review of the literature

Balzer¹,

Weiss²

2009

Human Pathology

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“…Others have suggested that desmoid tumors may arise from the fibrous capsule that forms around the implant in patients who underwent breast augmentation (1,7). Jewett et al showed histological continuity of the tumor with the fibrous capsule to support this hypothesis (7).…”

Section: Discussionmentioning

confidence: 94%

“…They have been described following various breast operations, including excisional biopsies, lumpectomies, mastectomies, breast reductions, and augmentations (6)(7)(8)(9). In the setting of breast implants, desmoid tumors have been hypothesized to arise from the fibrous capsule around the prosthesis (7).…”

Section: Introductionmentioning

confidence: 99%