Desmoid tumor following abdominally-based free flap breast reconstruction

Oh, Christine; Hammoudeh, Ziyad S.; Carlsen, Brian T.

doi:10.21037/gs.2016.06.01

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…The desmoid tumor of the breast can arise in the pectoral muscle or in the breast tissue (6,15), and may present clinically as a painless, firm, usually mobile mass occasionally fixed to the pectoral muscle or skin. Nipple discharge or palpable lymphadenopathy is not present (3)(4)(5)(6)13). The patients in our study did not have any clinical findings: the lesion in case 2 was very small and detected only at tomosynthesis, and the lesion in case 1 was located deep in the breast.…”

Section: Discussionmentioning

confidence: 65%

The effect of tumor removal via craniotomies on preoperative hydrocephalus in adult patients with intracranial tumors

et al. 2018

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The efficacy of tumor removal via craniotomies on preoperative hydrocephalus (HC) in adult patients with intracranial tumors is largely unknown. Therefore, we sought to evaluate the effect of tumor resection in patients with preoperative HC and identify the incidence and risk factors for postoperative VP shunt dependency. All craniotomies for intracranial tumors at Oslo University Hospital in patients ≥ 18 years old during a 10-year period (2004-2013) were reviewed. Patients with radiologically confirmed HC requiring surgery and subsequent development of shunt dependency were identified by cross-linking our prospectively collected tumor database to surgical procedure codes for hydrocephalus treatment (AAF). Patients with preexisting ventriculoperitoneal (VP) shunts (N = 41) were excluded. From 4774 craniotomies performed on 4204 patients, a total of 373 patients (7.8%) with HC preoperatively were identified. Median age was 54.4 years (range 18.1-83.9 years). None were lost to follow-up. Of these, 10.5% (39/373) required permanent CSF shunting due to persisting postoperative HC. The risk of becoming VP shunt dependent in patients with preexisting HC was 7.0% (26/373) within 30 days and 8.9% (33/373) within 90 days. Only secondary (repeat) surgery was a significant risk factor for VP shunt dependency. In this large, contemporary, single-institution consecutive series, 10.5% of intracranial tumor patients with preoperative HC became shunt-dependent post-craniotomy, yielding a surgical cure rate for HC of 89.5%. To the best of our knowledge, this is the first and largest study regarding postoperative shunt dependency after craniotomies for intracranial tumors, and can serve as benchmark for future studies.

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Section: Discussionmentioning

confidence: 65%

The effect of tumor removal via craniotomies on preoperative hydrocephalus in adult patients with intracranial tumors

et al. 2018

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“…The desmoid tumor of the breast can arise in the pectoral muscle or in the breast tissue (6,15), and may present clinically as a painless, firm, usually mobile mass occasionally fixed to the pectoral muscle or skin. Nipple discharge or palpable lymphadenopathy is not present (3–6,13). The patients in our study did not have any clinical findings: the lesion in case 2 was very small and detected only at tomosynthesis, and the lesion in case 1 was located deep in the breast.…”

Section: Discussionmentioning

confidence: 99%

“…Breast surgery, including excisional biopsy, lumpectomy, mastectomy, breast reduction and augmentation, reconstruction, and breast implants, has been reported in women presenting with desmoid tumor (4)(5)(6)14), suggesting that it can be induced by trauma. Our patient case 1 underwent breast reduction surgery two years before the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Desmoid tumor (synonym: desmoid-type fibromatosis) is a benign lesion of the connective tissue with a tendency to infiltrate adjacent tissue but without metastatic potential. Development in the breast is very rare (1)(2)(3)(4). Desmoid of the breast represents a diagnostic challenge because the lesions mimic breast carcinoma radiologically (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

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Screening-detected desmoid tumor of the breast: findings at conventional imaging and digital breast tomosynthesis

Samardžić

Lømo

Skaane

2018

Acta Radiologica Open

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Desmoid tumor of the breast is a rare benign entity that usually is mistaken for carcinoma clinically and radiologically. We report two cases of desmoid tumor of the breast detected by mammography screening using digital breast tomosynthesis (DBT). The larger tumor was detected at both full-field digital mammography (FFDM) and DBT. The smaller desmoid tumor, however, was identified only at tomosynthesis. Mammographic and ultrasonographic findings at diagnostic work-up were consistent with carcinoma of the breast. Preoperative needle biopsies could not conclusively diagnose the lesions. Both patients underwent excisional biopsy and histopathology revealed fibromatosis of the desmoid type.

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“…Desmoid tumors can originate anywhere within the body but are most common in the trunk and extremities. 13 Desmoid tumors are known to arise from muscular fascia or aponeurosis 1,14 and are also believed to arise within the pectoralis major muscle fascia or Cooper ligament. 14 Jewett, in 1979, suggested that when desmoid tumors are associated with breast implants, they could arise from the fibrous capsule that forms around the implant.…”

Section: Discussionmentioning

confidence: 99%

A nonrandom association of breast implants and the formation of desmoid tumors

et al. 2021

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Background: Studies suggest that surgical breast augmentation with implants is a risk factor for breast desmoid tumors. The statistical strength of this correlation is unknown, as evidence is limited to anecdotal reports. Methods:Patients with breast desmoid tumors and a history of breast implants seen at a single center between 2000 and 2021 were identified via radiology, breast, and sarcoma databases. The standardized incidence ratio (SIR) was calculated to assess the correlation between breast desmoid tumors and breast implants. The cases were pooled with published cases for analyses. Progression-free survival curves and hazard ratios were estimated using the Kaplan-Meier method and Cox proportional-hazards modeling.Results: Fourteen patients from one institution and 66 cases in the literature were identified. All patients were female, and the mean age was 38 years old (range 20-66). 63 patients (82%) underwent resection, 9 (12%) received chemotherapy, 3 (4%) received sorafenib, 11 (14%) received hormonal therapy, and 3 (4%) underwent active surveillance. After resection, the 2-year recurrence-free survival rate was 77% (95% CI 65%-89%). The recurrence risk was lower for resection with no residual tumor (R0) compared to microscopic (R1) or macroscopic (R2) residual tumor (HR: 0.15; 95% CI 0.02-0.8; p < 0.05). The SIR was 482 (95% CI 259-775) to 823 (95% CI 442-1322), suggesting a 482-823 times higher risk of developing a breast desmoid tumor after breast augmentation than the general population. Conclusion:We present a nonrandom association between breast implants and desmoid tumors. Whether the tumors arise from the surgical trauma or the implant's biomaterial is unknown. When surgery is indicated, negative margins reduce the risk of recurrence.

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Desmoid tumor following abdominally-based free flap breast reconstruction

Cited by 5 publications

References 18 publications

The effect of tumor removal via craniotomies on preoperative hydrocephalus in adult patients with intracranial tumors

The effect of tumor removal via craniotomies on preoperative hydrocephalus in adult patients with intracranial tumors

Screening-detected desmoid tumor of the breast: findings at conventional imaging and digital breast tomosynthesis

A nonrandom association of breast implants and the formation of desmoid tumors

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