Extent of intramolecular π stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the anticancer and antivirally active 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG). A comparison with related acyclic nucleotide analogues

Abstract

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Metal-Based Compounds in Antiviral Therapy

“…Furthermore, it is known that often the complexation with metal ions enhances the antiviral activities of drugs [ 14 ], in concordance with the importance of metal ions in biological systems [ 15 ]. More precisely, many compounds employed as drugs exhibit modified pharmacological and toxicological profiles when they are administered in their metal-based form.…”

“…For the acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG), active as anticancer and antiviral drug, the acidity constants as well as the stability constants of the Cu(II) complexes were obtained by potentiometric titrations in aqueous solutions at t = 25 °C, I = 0.1 M in NaNO 3 [ 15 ].…”

A Comprehensive Survey on the Expediated Anti-COVID-19 Options Enabled by Metal Complexes—Tasks and Trials

“…Sanarino and Shytaj [63] found that auranofin treats HIV better than chloroquine. With respect to biological systems [64], drug complexation with metal ions generally improves their antiviral activity [65].…”