Extended-spectrum beta-lactamase-positive Escherichia coli causing complicated upper urinary tract infection: Urologist should act in time

Abstract

Objective:Recently, many articles reported increased incidence of urinary tract infection (UTI) due to Extended-Spectrum Beta-Lactamase (ESBL)-producing E. coli. No data are available to date regarding patients presenting with complicated upper ESBL-positive E. coli UTI and sepsis. We report the clinical presentation, management, and outcomes in seven cases.Materials and Methods:This prospective study was carried out between January 2008 and September 2011. Follow-ups varied in patients according to their disease presentation and clinical outcomes. All strains were cultured and identified by the Clinical Microbiology Laboratory and were recovered from blood and urine cultures. In-vitro presence of ESBL was confirmed with Clinical and Laboratory Standard Institute double disc method.Results:In the study period, 49 patients needed hospitalization for upper UTI. Overall, in 25 patients (51%), cultures were negative. In the remaining, seven patients (14.3%) presented positive blood and urine-culture for ESBL + E. coli. Of these, four were female and three were male. Their median age was 73 years (range 66-84). The median hospital stay of these patients was 23 days (range 13 to 45 days).Conclusions:The current situation of multiple bacterial antibiotic resistance has become a worrisome issue in UTI. Multi-drug-resistant E. coli can be readily encountered in hospital settings during daily clinical practice, and urologist should act timely. The management of such infections is extremely important for the future, with particular reference to prevention of new antibiotic resistance patterns.

Antimicrobial resistance and prevalence of extended-spectrum beta-lactamase genes in Escherichia coli from major rivers in Podhale, southern Poland

“…The ESBL-producing strains are of particular concern due to the fact that they are resistant to all penicillins, cephalosporins and aztreonam. Moreover, they can exhibit cross-resistance to trimethoprim/sulfamethoxazole and quinolones (Picozzi et al 2014). The ESBL-conferring genes are located on large plasmids, which can carry the genes for resistance to numerous other groups of antimicrobials (Rawat and Nair 2010).…”

High prevalence of CTX-M-15 and first report of CTX-M-3, CTX-M-22, CTX-M-28 and plasmid-mediated AmpC beta-lactamase producing Enterobacteriaceae causing urinary tract infections in Bosnia and Herzegovina in hospital and community settings

“…Extended-spectrum b-lactamase (ESBL) producing gramnegative bacteria have been increasingly reported as causes of urinary tract infections (UTI) [1,2]. ESBLs production is the major resistance mechanism to oxymino-cephalosporins and aztreonam in Gram-negative bacteria [1].…”

Etiology of UTI and Frequency of ESBL Producing Bacteria Isolated from Patients of Dhaka Medical College Hospital with Their Antimicrobial Susceptibility Pattern

“…UTI caused by extendedspectrum beta-lactamase (ESBL)-producing organism have become a growing problem worldwide. 10 Infection with ESBL-producing bacteria raises mortality and it prolongs hospital stay along with an increase treatment cost 20 . ESBL production has been observed mostly in the Enterobacteriaceae mainly in Esch.…”