Expression of β1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma

Veeravarmal, Veeran; Austin, Ravi David; Nagini, Siddavaram; Nassar, Mohamed Hanifa Mohamed

doi:10.1016/j.prp.2017.10.013

Cited by 15 publications

(22 citation statements)

References 38 publications

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“…Transforming growth factor-beta has significant role in the production and deposition of extracellular matrix 3 by acting as a potent stimulator and is expressed in OSF tissue samples along with connective tissue growth factor. 20,21 The normal integrity of the connective tissue is maintained by balanced collagen metabolism depicted by equilibrium by the two enzymes MMPs and TIMPs. In OSF, this balance is disturbed resulting in increased deposition of ECM.…”

Section: Introductionmentioning

confidence: 99%

Oral Submucous Fibrosis;

Shaikh

Ahmed

Siddique

et al. 2019

TPMJ

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Objectives: Oral Submucous Fibrosis is a chronic, high risk, debilitating, pre-cancerous oral condition that is prevalent in Southeast Asian consumers of areca nut. This study was conducted to determine regarding gender specificity with relation to stages of OSF and medical & surgical treatment modalities. Setting: OSF patients treated at Oral Surgery clinics of Dow International Medical College, Dow University of Health Sciences. Period: From January 2016 to November 2017. Design of Study: Cross-sectional Hospital based study. Materials & Methods: Patients were divided into four groups based on their clinical presentations according to Khanna JN and Andrade NN classification. Two groups were divided based on treatment modalities. First group comprised of patients treated conservatively with medications and physiotherapy while the second group comprised of patients treated surgically. Results: Out of 225 patients treated with OSF, 88% of them were males while 12% were females with male to female ratio of 7:1. As per Khanna & Andrade classification, 9.7% belonged to group II, while 34.6% belonged to III and 55.5% of OSF patients belonged to IV-A. 56.8% of patients were treated conservatively while 43.1% were treated surgically. In the group of patients treated surgically, majority 84.6% of patients were treated with buccal fat pad while only 15.4% has nasolabial flap surgery performed. Conclusion: Statistical significant difference male preponderance in OSF disease severity was observed as compared to women in this sample of Pakistani population reporting to tertiary care hospital. A holistic approach should be undertaken with public health policies in place to discourage the use of areca nut products with or without tobacco and lower the burden of OSF in the general population.

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Section: Introductionmentioning

confidence: 99%

Oral Submucous Fibrosis;

Shaikh

Ahmed

Siddique

et al. 2019

TPMJ

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“…Conversely, the downregulation of β1-integrin leads to reduced membrane accumulation of the PTEN-Cav-1-β 1 -integrin complex. 9,66 This hampers the ability of PTEN to inactivate AKT signalling, 66 leading to fibroblast persistence and promoting fibrosis (Fig. 2b).…”

Section: Alterations In the Expression Pattern Of Om-scms In Osf Opmmentioning

confidence: 99%

“…Hyperplastic OSF and OSCC demonstrate increased stem cell activity, as evidenced by the upregulation of β 1 -integrin. 9 An increased β1-integrin expression pattern correlates with a greater tumorigenic potential, as indicated by the augmented tumour spheres and holoclonal colony formation in oral cancer cells compared to control cells. 67 The β 1 -integrin-driven transition from dormancy to tumorigenicity occurs through its activation by fibronectin/type-1 collagen and/or the activation of uPA receptor (uPAR).…”

Section: Alterations In the Expression Pattern Of Om-scms In Osf Opmmentioning

confidence: 99%

“…Polymerized collagen inhibits an excessive accumulation of ECM by activating β1-integrin. 9 , 66 When fibroblasts interact with polymerized type I collagen, caveolin-1 (Cav-1) forms a complex with phosphatase and tensin homologue (PTEN) and β1-integrin on the plasma membrane. 66 This places PTEN in the correct spatial location to inhibit the PI3K/AKT signal generated through the β 1 -integrin–matrix interaction, 66 thus promoting fibroblast apoptosis (Fig.…”

Section: Alterations In the Expression Pattern Of Om-scms In Osf Opmmentioning

confidence: 99%

“…2,5,6 Several reports suggest downregulated basal stem cell activity as a tipping event triggering epithelial atrophy in OSF. 4,[7][8][9][10][11][12][13][14] Limited scientific evidence supports a rebound amplification of stem cell activity in the epithelium transitioning from atrophic OSF to oral epithelial dysplasia (OED) and eventually to OSCC. A comprehensive assessment of oral mucosal stem cell markers (OM-SCMs) in relation to the progression of OSF, OED and OSCC is performed in this review (Figs.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

Sharma¹,

Fonseca

Hunter

et al. 2020

Int J Oral Sci

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The integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell markers (OM-SCMs) in oral submucous fibrosis (OSF), oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF. While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF, the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness. The vacillating expression patterns of OM-SCMs confirm the role of keratins 5, 14, 19, CD44, β1-integrin, p63, sex-determining region Y box (SOX2), octamer-binding transcription factor 4 (Oct-4), c-MYC, B-cell-specific Moloney murine leukaemia virus integration site 1 (Bmi-1) and aldehyde dehydrogenase 1 (ALDH1) in OSF, OPMDs and OSCC. The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.

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Fibrogenic Factors and Molecular Mechanisms

Kondaiah

2023

Textbooks in Contemporary Dentistry

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Expression of β1integrin in normal epithelium, oral submucous fibrosis and oral squamous cell carcinoma

Cited by 15 publications

References 38 publications

Oral Submucous Fibrosis;

Oral Submucous Fibrosis;

Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

Fibrogenic Factors and Molecular Mechanisms

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