Background: Panoramic radiographs are the most common radiographic tool used by the dental clinicians to evaluate teeth, mandible and other related structures of the jaws. Mandibular condyle is an important anatomical landmark for facial growth, expressed in an upward and backward direction. The presentation of mandibular condyle differs widely among different group of ages and individuals. Materials and methods:The retrospective cross-sectional study was conducted from Nov 2018 to March 2019 at Dow International Dental College (DIDC) Karachi that includes radiographic evaluation of 500 mandibular condyles. All retrievable OPGs were obtained and data were extracted regarding age, gender and condylar morphology. Results:The morphological appearances of mandibular condyle have great variation among different age groups and subjects. Normally we recognize five basic shapes i.e. Oval, Bird beak, crooked finger, diamond and mixed. Out of 250 pair of condylar heads that were evaluated, 50% were oval, 40% bird beak, 4.8% crooked finger and diamond 4.8%. Conclusions:All four morphological types of mandibular condyles were observed and the oval shape condyles were most prevalent among both genders and all age groups. In future studies, the inclusion of other parameters and large sample size may provide unique information.
Background Oral squamous cell carcinoma is a global threat and accounts for approximately 90% of malignant oral lesions. The emergence of oral carcinoma is linked to precancerous lesions, which act as precursors of the disease. Matrix metalloproteinases appear to play a significant role in the pathogenesis of both precancerous conditions and oral malignancies due to their participation in remodeling of the extracellular matrix. Methodology This is an analytical study conducted at Dow University of Health Sciences, Pakistan. Unstimulated saliva samples were collected from healthy, oral submucous fibrosis and oral squamous cell carcinoma patients. The level of MMP-12 was estimated using enzyme-linked immunosorbent assay. One-way Analysis of variance was run to determine if MMP-12 levels differ between the three groups, which was preceded by post hoc Tuckey test. MMP-12 cut off values were determined using Receiver operating characteristic curve. Results A significant difference in salivary MMP-12 expression was observed in OSF and OSCC (p < 0.001). The expression of salivary MMP-12 was higher in OSF and OSCC patients as compared to the healthy group (p < 0.001). The mean MMP-12 expression in OSCC appeared higher than in OSF cases (p < 0.05). MMP-12 value of $$\ge$$ ≥ 4.05 ng/ml and $$\ge$$ ≥ 4.20 ng/ml is predictive of OSF and OSCC respectively, with 100% sensitivity and specificity (p < 0.001). Conclusion Increased expression of MMP-12 appears as the healthy patient advances to OSF and OSCC. The study results also demonstrate higher MMP-12 expression in OSCC patients as compared to OSF. Therefore, the estimation of salivary MMP-12 serves as a valuable non-invasive early diagnostic tool in diagnosing oral submucous fibrosis and oral squamous cell carcinoma.
Objectives: Oral Submucous Fibrosis is a chronic, high risk, debilitating, pre-cancerous oral condition that is prevalent in Southeast Asian consumers of areca nut. This study was conducted to determine regarding gender specificity with relation to stages of OSF and medical & surgical treatment modalities. Setting: OSF patients treated at Oral Surgery clinics of Dow International Medical College, Dow University of Health Sciences. Period: From January 2016 to November 2017. Design of Study: Cross-sectional Hospital based study. Materials & Methods: Patients were divided into four groups based on their clinical presentations according to Khanna JN and Andrade NN classification. Two groups were divided based on treatment modalities. First group comprised of patients treated conservatively with medications and physiotherapy while the second group comprised of patients treated surgically. Results: Out of 225 patients treated with OSF, 88% of them were males while 12% were females with male to female ratio of 7:1. As per Khanna & Andrade classification, 9.7% belonged to group II, while 34.6% belonged to III and 55.5% of OSF patients belonged to IV-A. 56.8% of patients were treated conservatively while 43.1% were treated surgically. In the group of patients treated surgically, majority 84.6% of patients were treated with buccal fat pad while only 15.4% has nasolabial flap surgery performed. Conclusion: Statistical significant difference male preponderance in OSF disease severity was observed as compared to women in this sample of Pakistani population reporting to tertiary care hospital. A holistic approach should be undertaken with public health policies in place to discourage the use of areca nut products with or without tobacco and lower the burden of OSF in the general population.
Introduction: Maxillofacial trauma is a regularly reported occurrence in theemergency room. Of all maxillofacial injuries worldwide, the mandible is the most commonlyinvolved facial bone, with etiologies ranging from assaults and interpersonal violence to RTAs.Objectives: We aim to identify the patterns of incidence, etiology, age groups, anatomicallocation and gender in mandibular fractures in the population of Karachi, Pakistan. StudyDesign: Observational cross sectional study. Setting: Dow International Dental College. Period:January 2012 – September 2017. Materials and Methods: Informed consent was obtainedalong with a comprehensive history; a systematic clinical examination was supplemented byradiographs of the face as required to confirm the presence of fractures. Statistical analysis wasdone using SPSS v.21. Results: Over 5 years, an overall 156 patients sustained 250 fractures ofthe mandible. Most affected gender was male, the age group was 20-30 years, most commoncause was Road Traffic Accidents and site was the parasymphysis. Conclusion: Mandibularfractures have a higher incidence in young males driving motorbikes or cars. More rigorouslegislative action and community awareness is required to lessen the rate of mandibularfractures in Karachi, Pakistan.
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