Oral Submucous Fibrosis;

Abstract

Objectives: Oral Submucous Fibrosis is a chronic, high risk, debilitating, pre-cancerous oral condition that is prevalent in Southeast Asian consumers of areca nut. This study was conducted to determine regarding gender specificity with relation to stages of OSF and medical & surgical treatment modalities. Setting: OSF patients treated at Oral Surgery clinics of Dow International Medical College, Dow University of Health Sciences. Period: From January 2016 to November 2017. Design of Study: Cross-sectional Hospital based study. Materials & Methods: Patients were divided into four groups based on their clinical presentations according to Khanna JN and Andrade NN classification. Two groups were divided based on treatment modalities. First group comprised of patients treated conservatively with medications and physiotherapy while the second group comprised of patients treated surgically. Results: Out of 225 patients treated with OSF, 88% of them were males while 12% were females with male to female ratio of 7:1. As per Khanna & Andrade classification, 9.7% belonged to group II, while 34.6% belonged to III and 55.5% of OSF patients belonged to IV-A. 56.8% of patients were treated conservatively while 43.1% were treated surgically. In the group of patients treated surgically, majority 84.6% of patients were treated with buccal fat pad while only 15.4% has nasolabial flap surgery performed. Conclusion: Statistical significant difference male preponderance in OSF disease severity was observed as compared to women in this sample of Pakistani population reporting to tertiary care hospital. A holistic approach should be undertaken with public health policies in place to discourage the use of areca nut products with or without tobacco and lower the burden of OSF in the general population.

Influence of Risk Habits on Demographic Factors and its Impact on Oral Submucous Fibrosis

“…Reason could be ignorance or lack of awareness for seeking dental consultation earlier instead of only when their mouth opening became limited. These findings are consistent with Salam et al 13 , Shaikh et al 14 in both studies most patients presented at stage III and IV, however these findings are in contrast from Kumar 15 in which greater percentage of patients presented at stage II (41.94%).…”

Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma

“…The rate of malignant transformation to oral cancer is 9.13%, and there is a 29.26 times higher risk in OSF patients than non-OSF patients [ 35 , 36 ]. In Pakistan, OSF is contemplated as a public health concern as oral malignancies are one of the most common malignancies reported [ 37 ]. Also, oral habits like tobacco smoking and consumption of betel nut and smokeless tobacco are major risk factors of OSF and are common in Pakistan.…”

Role of Nigella sativa Extract in Reducing the Inflammatory Damage in Oral Submucous Fibrosis – A Review

“…Nigella sativa (N. sativa) is an herb, which belongs to family Ranunculaceae 1 . It is mainly cultivated in countries such as Bangladesh, Pakistan, India, Iran, Turkey, and Saudi Arabia and in several areas of Middle East and South Europe [2][3][4] . Seeds of N. sativa have been commonly used as a flavoring and seasoning agent for preparing different cuisines in many Asian and Eastern countries over centuries 1,5 .…”