2011
DOI: 10.3171/2011.5.spine10303
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Abstract: Object Aquaporins (aqp) are protein channels providing water transport across cell membranes. The main member of this family expressed in the CNS is aqp-4. The pattern and amount of expression of this channel suggest a dominant role in bulk water movement into the nervous tissue. It has also been shown to play a role in several water balance disorders in the CNS. In this study, the authors investigated the possible role of aqp-4 in syringomyelia. Show more

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Cited by 8 publications
(5 citation statements)
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“…Nonsurgical treatments are needed to overcome the risks and challenges of current therapeutic interventions. Unfortunately, there is a poor understanding of the basis for SM [ 30 ], and in response, the molecular aspects of SM have been a recent research focus in the field [ 12 15 ]. These studies provide a solid foundation for the development of non-surgical treatments for SM; because it is important to establish further analytical tools, particularly those that monitor functional outcomes over time to evaluate treatment efficacy.…”
Section: Discussionmentioning
confidence: 99%
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“…Nonsurgical treatments are needed to overcome the risks and challenges of current therapeutic interventions. Unfortunately, there is a poor understanding of the basis for SM [ 30 ], and in response, the molecular aspects of SM have been a recent research focus in the field [ 12 15 ]. These studies provide a solid foundation for the development of non-surgical treatments for SM; because it is important to establish further analytical tools, particularly those that monitor functional outcomes over time to evaluate treatment efficacy.…”
Section: Discussionmentioning
confidence: 99%
“…Multiple competing theoretical mechanisms have attempted to explain syrinx formation/expansion [ 7 11 ]. More recent work, including our own, has explored molecular aspects of SM to attempt to better understand the connections to SM pathology [ 12 16 ] while also extending this to animal PTSM models [ 10 , 15 , 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…The central canal expands on either side of these occlusions, producing an ependyma-lined syrinx. 37 This model differs from the intracisternal kaolin model of syringomyelia used in the studies by Aghayev et al, 1 in that it produces dilation of the central canal without communication with the fourth ventricle. 37 The intracisternal kaolin model produces ventricular enlargement, resulting in raised intracranial pressure, as well as dilation of the central canal.…”
Section: Animal Modelmentioning
confidence: 97%
“…44 Recent studies have investigated AQP4 changes in a model of communicating canalicular syringomyelia. 1,58 To the best of our knowledge, the study reported here is the first to look at AQP4 expression in noncommunicating canalicular syringomyelia.…”
mentioning
confidence: 90%
“…However, no effective results were obtained 4 hours after the treatment. Early intervention could be more effective before the onset of cytotoxic edema at a very early period within hours after the trauma (1,2,3,8,20,21,29). Therefore, the modification of the antisense dose or a change in time intervals of administration may be considered.…”
mentioning
confidence: 99%