Expression of Tumor Necrosis Factor-a and Interleukin-6 in Chronic Suppurative Otitis Media

Edward, Yan; Munilson, Jacky; Rosalinda, Rossy; Ali, Hirowati; Irfandy, Dolly; Swanda, Delva

doi:10.25002/tji.2019.782

Cited by 2 publications

(2 citation statements)

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“…In an immunohistochemical study evaluating patients with CCOM, Liu et al determined that IL-6 expression was 72% in the cholesteatoma tissue samples and 20% in the normal ears (Liu et al, 2014). Similarly, Edward et al stated that IL-6 expression was four times higher in the ears with CCOM compared to the healthy ears (Edward et al, 2019). In our study, the serum IL-6 level was higher in patients with CCOM compared to the control group, but this difference was not statistically significant.…”

Section: Discussioncontrasting

confidence: 65%

Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media

et al. 2022

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In this study we aimed to investigate epidermal growth factor (EGF), interleukin (IL1)-α and IL-6 levels, and hematological parameters in the serum samples of patients with chronic cholesteatomatous otitis media (CCOM). This prospective included 40 patients who underwent surgery due to CCOM between June 2020 and May 2021. The stage of middle ear cholesteatoma was determined on each chart using the EAONO/JOS system. The control group comprised of 30 adults who were scheduled for septoplasty over the same period in our hospital, had no otological complaints, and had normal otological findings. The demographic, clinical, and laboratory data of the patients were obtained from the electronic medical record system of our hospital. The serum EGF, IL1-α and IL-6 levels, and hematological parameters (neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV)) were compared between the CCOM and control groups. Seven patients had Stage 1 and 33 patients had Stage 2 middle ear cholestatoma. There was no statistically significant difference between the CCOM and control groups in terms of age and gender (p=0.092 and p=0.616, respectively). The serum EGF and IL1-α levels of the CCOM group were statistically significantly higher than those of the control group (p=0.047 and p=0.013, respectively). No statistically significant difference was observed in the serum IL-6 levels of the CCOM and control groups (p=0.675). There was also no significant difference between the CCOM and control groups in terms of the mean NLR and MPV values (p=0.887 and p=0.164, respectively). There was no significant difference between the Stage 1 and Stage 2 cholesteatoma subgroups in terms of the mean EGF, IL1-α, IL-6 levels (p=0.204, p=0.557 and p=0.613, respectively), and the mean NLR and MPV values (p=0.487, p=0.439, respectively). Increased serum EGF and IL1-α levels in patients with CCOM suggest that these cytokines may play a role in cholesteatomatous epithelial hyperproliferation.

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Section: Discussioncontrasting

confidence: 65%

Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media

et al. 2022

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“…In this study, there was a tendency to increase the expression of the CCL27 gene; this may be the role of the TNF alpha pathway through ERK, p38, JNK, and NFĸB [17]. In our previous study, there was an increase in the expression of the TNF alpha gene in cholesteatoma compared to retro skin auricles [19]. Maniu [6] also obtained the same results where there was an increase in TNF alpha gene expression, while the pathway that suppresses CCL27 by TNF alpha and gamma IFN through EGFR, ERK, and STAT3 has not.…”

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confidence: 52%

Expression of CCL27 in Middle Ear Cholesteatoma

Edward

Decroli

Ali

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Cholesteatoma is a lesion of the temporal bone lined by stratified squamous epithelium that contains desquamated keratin. Cholesteatoma is considered more aggressive during childhood. The molecular mechanism of the pathogenesis of cholesteatoma formation is still unclear. Previous studies reported on immunohistochemical examination and quantitative polymerase chain reaction (PCR) found that TCN1 and CCL27 were involved in the process of cholesteatoma keratinocytes and dermal endothelial cells. In skin tumors derived from keratinocytes, there is a protective mechanism of antitumor T cell-mediated by reducing CCL27 expression. AIM: The objective of this study was to investigate the expression of chemokine ligand 27 (CCL27) in cholesteatoma. METHODS: This is a cross-sectional comparative study. Cholesteatoma specimens were obtained from 15 patients who underwent surgery and 15 normal retroauricular skin as control. The specimen’s gene expression was examined with real-time PCR (RT-PCR). RESULTS: The expression of CCL27 was 36.215 ± 45.848 ng/ul in cholesteatoma, while it is 9.692 ± 15.760 ng/ul in normal retroauricular skin. The expression of CCL 27 in cholesteatoma was higher than in normal retroauricular skin, but it was not significant (p > 0.05) CONCLUSION: The expression of CCL27 in cholesteatoma was higher than in normal retroauricular skin.

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Expression of Tumor Necrosis Factor-a and Interleukin-6 in Chronic Suppurative Otitis Media

Cited by 2 publications

References 0 publications

Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media

Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media

Expression of CCL27 in Middle Ear Cholesteatoma

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