Expression of the von Willebrand Factor in Atrial Endocardium is Increased in Atrial Fibrillation Depending on the Extent of Structural Remodeling

Diagnosis of Left Atrial Appendage Thrombi by Multiplane Transesophageal Echocardiography Interlaboratory Comparative Study

“…[1][2][3][4][5] Especially in patients before electrical cardioversion of atrial fibrillation, the detection of LAAT by TEE is of clinical relevance. [6][7][8][9][10] In the beginning of the TEE era there were problems in differentiating LAAT from pectinate muscles using mono-or biplane probes, [11][12][13][14][15] which resulted in a high interobserver variability. 16,17 Multiplane TEE probes are assumed to improve the diagnosis of LAAT.…”

Acute Myocardial Infarction in a Patient With Essential Thrombocythemia Successful Treatment With Percutaneous Transluminal Coronary Recanalization

“…Platelets are a major source of von Willebrand factor, [11][12][13][14][15] which is known to play a major role in the onset of coronary arterial thrombosis. In the present patient, von Willebrand factor was high (184%), emphasizing the need to control the platelet count.…”

“…These complications did not cause a severe anemia that required blood transfusion. Von Willebrand factor is known to play crucial role in the onset of arterial thrombosis [11][12][13][14][15] and her plasma von Willebrand factor was high at 184%.…”

Molecular Basis of Thromboembolism in Association With Atrial Fibrillation

“…31 Since then, many investigators have begun to pay attention to the function of the atrial endocardial cells, a barrier between the blood and atrial cardiomyocytes. [32][33][34][35][36][37] Cai et al demonstrated that AF decreased nitric oxide synthase expression and increased PAI-1 expression in the atrial endocardium of pigs. 32 My group have also shown that AF decreases the mRNA and protein expressions of TFPI and TM in rats.…”

“…34 Several investigators have shown evidence that endocardial function is also impaired in human AF. [35][36][37] Fukuchi et al reported that von Willebrand factor is present on the surface of the atrial endocardium in AF patients. 35 Other investigators have demonstrated the expression of tissue factor in specimens from the atrium of AF patients undergoing valvular surgery.…”