Expression of steroidogenic enzymes in human sebaceous glands

Inoue, Tsukasa; Miki, Yasuhiro; Kakuo, Shingo; Hachiya, Akira; Kitahara, Takashi; Aiba, Setsuya; Zouboulis, Christos C.; Sasano, Hironobu

doi:10.1530/joe-14-0323

Cited by 31 publications

(22 citation statements)

References 54 publications

(63 reference statements)

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“…In human sebaceous glands (SGs), PPARs are expressed mostly in basal and early differentiated sebocytes, with decreased expression with terminal sebaceous differentiation . There is increased expression of PPAR γ in sebocytes during puberty . PPAR γ is also abundantly expressed in skin adipocytes and plays a critical role in adipocyte differentiation .…”

Section: The Physiological Roles Of Pparγ In the Skinmentioning

confidence: 99%

The role of PPARγ‐mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

Ramot

Mastrofrancesco

Camera

et al. 2015

Experimental Dermatology

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Yuval Ramot and Arianna Mastrofrancesco contributed equally to this work.Abstract: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that modulate the expression of multiple different genes involved in the regulation of lipid, glucose and amino acid metabolism. PPARs and cognate ligands also regulate important cellular functions, including cell proliferation and differentiation, as well as inflammatory responses. This includes a role in mediating skin and pilosebaceous unit homoeostasis: PPARs appear to be essential for maintaining skin barrier permeability, inhibit keratinocyte cell growth, promote keratinocyte terminal differentiation and regulate skin inflammation. They also may have protective effects on human hair follicle (HFs) epithelial stem cells, while defects in PPARc-mediated signalling may promote the death of these stem cells and thus facilitate the development of cicatricial alopecia (lichen planopilaris). Overall, however, selected PPARc modulators appear to act as hair growth inhibitors that reduce the proliferation and promote apoptosis of hair matrix keratinocytes. The fact that commonly prescribed PPARc-modulatory drugs of the thiazolidine-2,4-dione class can exhibit a battery of adverse cutaneous effects underscores the importance of distinguishing beneficial from clinically undesired cutaneous activities of PPARc ligands and to better understand on the molecular level how PPARc-regulated cutaneous lipid metabolism and PPARcmediated signalling impact on human skin physiology and pathology. Surely, the therapeutic potential that endogenous and exogenous PPARc modulators may possess in selected skin diseases, ranging from chronic inflammatory hyperproliferative dermatoses like psoriasis and atopic dermatitis, via scarring alopecia and acne can only be harnessed if the complexities of PPARc signalling in human skin and its appendages are systematically dissected.

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Section: The Physiological Roles Of Pparγ In the Skinmentioning

confidence: 99%

The role of PPARγ‐mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

Ramot

Mastrofrancesco

Camera

et al. 2015

Experimental Dermatology

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“…Increased HSD17B2 mRNA expression was associated with decreased testosterone levels in SZ95 immortalized sebocytes (30). While inactivation of testosterone via increased HSD17B2 lead to hypoandrogenic milieu, simultaneous effect of HSD17B2 on estradiol inactivation may counteract this hypoandrogenic situation.…”

Section: P-usbmentioning

confidence: 91%

Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH

Taheri

Zararsız

Karaburgu

et al. 2015

European Journal of Endocrinology

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Objective: Hirsutism results from hyperandrogenemia and/or exaggerated androgen responsiveness. Among various causes of hirsutism, some patients do not exhibit androgen excess which is called idiopathic hirsutism (IH). The pathogenesis of IH could not so far be clearly established. Design: To investigate the mRNA expression of aromatase enzyme and the other enzymes having functional roles in the steroidogenic pathway, in freshly obtained skin tissue from subumbilical skin and the arm of the patients with IH and healthy women. Methods: Twenty-one women with IH and 15 healthy women were included in the study. We aimed to determine mRNA expressions of genes associated with local androgen synthesis and metabolism (CYP11A1, STS, CYP19A1, SRD5A1, SRD5A2, HSD3B1, AR, COMT, ESR1, ESR2, HSD3B2, CYP17A1, SULT2A1, SULT1E1, HSD17B2, IL6, TGFB1, TNFA) from skin biopsy and blood samples of patients with IH and the data compared with healthy subjects. Results: Patients with IH exhibit significantly lower interleukin 6 (IL6) mRNA expression and higher steroid sulphatase (STS) and hydroxysteroid (17beta) dehydrogenase 2 (HSD17B2), gene mRNA expression, respectively, in the subumbilical region skin biopsies. Similarly, patients with IH exhibit significantly lower IL6 mRNA expression and higher STS and HSD17B2 gene mRNA expression, respectively, in the arm skin compared to healthy women's subumbilical region. Conclusions: In both arm and subumbilical skin biopsy of patients with IH, we observed an up-regulation of HSD17B2 and STS, decreased IL6 mRNA expression, probably determining an increase in the local amount of active androgens, which could then be used as substrate for other androgen metabolic routes.

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“…5 Pada masa remaja terjadi peningkatan hormon seks terutama hormon androgen yang menyebabkan terjadinya peningkatan ukuran kelenjar sebasea, menstimulasi produksi sebum, dan proliferasi keratinosit pada duktus kelenjar sebasea dan akroinfundibulum sehingga terbentuknya lesi noninflamasi dan lesi inflamasi. 5,6 Penelitian oleh Ayudianti di RSUD Dr. Soetomo Surabaya tahun 2014 menunjukkan hormon sebagai fakfor pencetus tersering AV dengan persentase berdasarkan jenis kelamin yang dipengaruhi oleh hormon, yaitu 89,0% pada perempuan dan 11,0% pada laki-laki. Hormon lebih berpengaruh pada wanita saat menstruasi dan peningkatan hormon sebelum menstruasi akan memengaruhi eksaserbasi serta memperburuk AV.…”

Section: Pendahuluanunclassified

Pengaruh Fase Menstruasi Terhadap Derajat Akne Vulgaris Mahasiswi Fakultas Kedokteran Universitas Riau

Widiawaty

Darmani

Amelinda

2019

MDVI

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ABSTRAKAkne vulgaris merupakan penyakit inflamasi kronik unit pilosebasea yang ditandai adanya komedo, papul, pustul, nodul dengan tempat predileksi di wajah, lengan bagian atas, dada, dan punggung, yang sering terjadi pada remaja serta dewasa muda. Akne vulgaris pada wanita dapat dipengaruhi oleh hormon yaitu pada saat premenstruasi terjadi penurunan hormon estrogen dan peningkatan hormon progesteron yang dapat memperberat akne vulgaris.Tujuan penelitian ini adalah untuk mengetahui hubungan fase menstruasi dengan derajat akne vulgaris. Dilakukan penelitian analitik observasional pada 89 mahasiswa yang menderita akne vulgaris. Penilaian derajat akne vulgaris menggunakan kriteria Lehmann saat premenstruasi dan pascamenstruasi.Subjek penelitian terdiri atas remaja usia 17 sampai 21 tahun. Uji Marginal Homogeneity menunjukkan hubungan yang bermakna antara fase menstruasi dengan derajat akne vulgaris dengan nilai p=0,001. Kata Kunci: Akne vulgaris, fase menstruasi, derajat akne vulgaris.ABSTRACT Acne vulgaris is an inflammatory disease in the pilosebaceus unit characterized by comedones, papules, pustules, or nodules that usually affecting adolescents as well as young adults. Its predilection are face, upper shoulders, chest, and back. Acne vulgaris that is affected by hormones at the time of premenstruation which estrogen hormone is decreasing and progesterone level is increasing that can aggravate acne vulgaris.The aim of this study is to determine whether there is a relationship between menstrual phase with acne vulgaris' severity grade. An observational analytic study was performed on 89 students age 17 to 21 years suffering from acne vulgaris. The degree of acne vulgaris assessed using Lehmann's criteria before and after menstrual period. Marginal Homogeneity test showed a significant relationship between menstrual phase and degree of acne vulgaris (p= 0,001).

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Expression of steroidogenic enzymes in human sebaceous glands

Cited by 31 publications

References 54 publications

The role of PPARγ‐mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

The role of PPARγ‐mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology

Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH

Pengaruh Fase Menstruasi Terhadap Derajat Akne Vulgaris Mahasiswi Fakultas Kedokteran Universitas Riau

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