Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH

Taheri, Serpil; Zararsız, Gökmen; Karaburgu, Sulbiye; Borlu, Murat; Özgün, Mahmut Tuncay; Karaca, Züleyha; Tanrıverdi, Fatih; Dündar, Munis; Keleştimur, Fahrettin; Ünlühızarcı, Kürşad

doi:10.1530/eje-15-0460

Cited by 11 publications

(4 citation statements)

References 32 publications

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“…Previous studies have shown that the expression of the type 2 17β-HSD gene is lower in scalp hair follicles of women with hirsutism than of women without it but similar to that of men [ 19 ], and higher in the subumbilical region and arm skin [ 20 ]. These results suggest that type 2 17β-HSD may play a role in the development of hirsutism, as the enzyme is responsible for inactivating more potent sex steroids (such as testosterone) by oxidation reactions [ 19 ].…”

Section: Actions and Metabolism Of Androgens In The Hair Folliclementioning

confidence: 99%

Hirsutism, Normal Androgens and Diagnosis of PCOS

et al. 2022

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Hirsutism is defined as the presence of terminal hair with male pattern distribution in women. While in the general population, hirsutism affects around 4–11% of women, it is the main manifestation of hyperandrogenism in women with polycystic ovary syndrome (PCOS), with a prevalence estimated at 65–75%. Hirsutism in PCOS is associated with both androgen excess and individual response of the pilosebaceous unit to androgens. The modified Ferriman–Gallwey (mFG) scoring system has been widely used in clinical practice to visually score excessive terminal hair, thus standardizing hirsutism evaluation and facilitating data comparison. Although a universal mFG score cutoff would be useful for comparisons, ethnic variations, as well as skin type and other factors, should be considered when evaluating hirsutism in distinct populations. In turn, androgen levels, measured by conventional techniques, have been shown to correlate poorly with the severity of hirsutism. Indeed, while most women with PCOS and hirsutism also have higher than reference values for serum androgen levels, some of them may not present with biochemical hyperandrogenism, representing a challenge to the diagnosis of PCOS. In this article, we critically review this not uncommon condition in women with PCOS presenting with hirsutism but normal androgen levels.

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Section: Actions and Metabolism Of Androgens In The Hair Folliclementioning

confidence: 99%

Hirsutism, Normal Androgens and Diagnosis of PCOS

et al. 2022

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“…S. Taheri [40] reasoned that done patients with idiopathic infection hirsutism [IH], a expansion in the nearby add up about dynamic androgens were observed, which Might that point a chance to be utilized Similarly as An substrate to other androecium metabolic routes.…”

Section: Discussionmentioning

confidence: 99%

Second to Fourth Digit Ratio in Patients with Hirsutism and Its Correlation with Hormonal Assay

El-Taweel

Hamed

Sebaey

et al. 2018

Benha Journal of Applied Sciences

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Hirsutism will be a basic clinical state seen On female patients of constantly on ages. It influences around 5-10% of the ladies. The cause may be mostly hyperandrogenism, which might be ovarian or adrenal. It might be and only an uncommon metabolic syndrome, medication induced, alternately barely idiopathic infection.The point about this fill in may be with assess those seconds should fourth digit length proportion over patients with hirsutism and its correspondence with hormonal profile. This examine included 50 female patients torment from hirsutism as stated by altered Ferriman Furthermore Gallwey score, done addition, 30 Obviously solid people from claiming matched age. The results of the present study showed that patients had statistically significant higher levels than controls in Prolactin [P=0.000] and DHEA-S [P=0.005] with no statistically significant difference in other hormones and there was no significant correlation between second to fourth digit ratio and all the laboratory investigations in both hands. the study concluded that the assessment of hirsutism is a multifactorial and that 2D:4D ratio is very promising tool in the diagnosis of hirsutism and the assessment of its severity.

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“…There is evidence demonstrating the association of hyperandrogenism disorders, particularly PCOS, with metabolic disturbances like dyslipidemia, which has been defined as increased concentrations of triglyceride (TG) or low‐density lipoprotein cholesterol (LDL‐C) or decreased values of high‐density lipoprotein cholesterol (HDL‐C), or receiving lipid‐lowering therapy 7 ; findings remained significant even after adjusting to obesity 8–11 . Moreover, epidemiologic studies indicate that IH as a mild hyperandrogenism condition with a peripheral increased androgen activity might also be associated with some metabolic disturbances, such as dyslipidemia 12–14 . Since some investigators have described mild forms of ovarian and adrenal functional hyperandrogenism in some patients with IH, it is logical that IH increases the risk of metabolic disturbances in a similar manner of PCOS 15,16 …”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11] Moreover, epidemiologic studies indicate that IH as a mild hyperandrogenism condition with a peripheral increased androgen activity might also be associated with some metabolic disturbances, such as dyslipidemia. [12][13][14] Since some investigators have described mild forms of ovarian and adrenal functional hyperandrogenism in some patients with IH, it is logical that IH increases the risk of metabolic disturbances in a similar manner of PCOS. 15,16 Despite existing several kinds of studies on IH and its association with metabolic disturbances, [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] a limited number of studies have assessed lipid profiles in patients with IH with conflicting and inconclusive results.…”

Section: Introductionmentioning

confidence: 99%

Idiopathic hirsutism and dyslipidemia: A systematic review, meta‐analysis, and meta‐regressions

Amiri

Mahmoudieh

Sheidaei

et al. 2023

J of Cosmetic Dermatology

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Background Despite existing several kinds of studies on idiopathic hirsutism (IH) and its association with metabolic disturbances, a limited number of studies have assessed lipid profiles in patients with IH with conflicting and inconclusive results. This study aimed to evaluate the lipid profiles in women with IH, compared to those of polycystic ovary syndrome (PCOS) and healthy controls. Materials and Methods For this systematic review and meta‐analysis, PubMed, Scopus, and EMBASE databases were searched to obtain studies published from inception to July 2021 investigating the lipid parameters, including triglyceride (TG), total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), and high‐density lipoprotein cholesterol (HDL‐C) in women with IH, compared to control groups. A meta‐regression and subgroup analysis were conducted to explore heterogeneity sources. Publication bias was assessed by the Egger test. Results Of 209 studies retrieved through searching databases and other sources, a total of 12 studies including 3913 participants were included for the meta‐analysis. This meta‐analysis showed higher standardized mean difference (SMD) of TC (SMD: 0.09 mg/dl; 95% CI: 0.001, 0.18) and lower SMD of HDL‐C (SMD: −0.10 mg/dl; 95% CI: −0.18, −0.02) in women with IH, compared to those of the healthy controls, whereas there were no significant differences in the SMDs of TG and LDL‐C between the study groups. This study also revealed no difference in the levels of lipid profiles of women with IH in comparison with PCOS patients, except for TG (SMD: −0.24 mg/dl; 95% CI: −0.46, −0.02). The results of subgroup analysis based on the study design revealed no significant differences in the SMD of lipid parameters between women with IH and healthy controls. We also found no significant difference in the levels of lipid profiles of women with IH versus PCOS patients, except for HDL‐C in the subgroup of case–control studies (SMD: 0.18 mg/dl; 95% CI: 0.01, 0.34). Conclusion This study demonstrated that the majority of lipid parameters were not significantly different in women with IH, compared to those of healthy and PCOS controls.

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Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH

Cited by 11 publications

References 32 publications

Hirsutism, Normal Androgens and Diagnosis of PCOS

Hirsutism, Normal Androgens and Diagnosis of PCOS

Second to Fourth Digit Ratio in Patients with Hirsutism and Its Correlation with Hormonal Assay

Idiopathic hirsutism and dyslipidemia: A systematic review, meta‐analysis, and meta‐regressions

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