2009
DOI: 10.1007/s10528-009-9310-y
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Expression of New Red Cell–Related Genes in Erythroid Differentiation

Abstract: Using a suppression subtractive hybridization method, we have previously identified genes differentially expressed in erythroid cells heterozygous for large deletions in beta-like globin cluster. Herein, we investigated the expression of four newly detected red cell-related genes in erythroid differentiation. ARID1B and TSPYL1, genes with chromatin remodeling properties, presented similar patterns of expression with an upregulation after erythropoietin (EPO) addition, similar to previous data found in reticulo… Show more

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Cited by 11 publications
(8 citation statements)
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References 19 publications
(23 reference statements)
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“…Our whole-genome analysis of Andean high-altitude human dwellers from the two groups (CMS and non-CMS) established ARID1B as a key gene under selection in that population 5 . Supporting the hypothesis that ARID1B has a potential role in the regulation of erythropoiesis at high altitude, previous studies have suggested a possible role of ARID1B in erythroid differentiation 11 , 12 . In β-thalassemia patients, ARID1B is differentially expressed during erythroid development 12 , but its mechanism and role in pathology are still unknown.…”
Section: Introductionmentioning
confidence: 63%
“…Our whole-genome analysis of Andean high-altitude human dwellers from the two groups (CMS and non-CMS) established ARID1B as a key gene under selection in that population 5 . Supporting the hypothesis that ARID1B has a potential role in the regulation of erythropoiesis at high altitude, previous studies have suggested a possible role of ARID1B in erythroid differentiation 11 , 12 . In β-thalassemia patients, ARID1B is differentially expressed during erythroid development 12 , but its mechanism and role in pathology are still unknown.…”
Section: Introductionmentioning
confidence: 63%
“…It is important to note that the SNP in CPA3 had an MAF of <5%, and previous studies have demonstrated that rare genotypes are more likely to result in spurious findings [35]. Third, the SH3BGRL2 gene is a homolog to the SH3BGR gene, and their protein products belong to the thioredoxin-like protein superfamily of redox-active proteins, including thioredoxin and glutaredoxin [36,37]. Specifically, thioredoxins are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange.…”
Section: Discussionmentioning
confidence: 99%
“…The detailed mechanism of how ZHX2 affects the abundance of γ-globin mRNA is currently unknown. Intriguingly, during the preparation of this manuscript de Andrade et al 16 reported the marked down regulation of ZHX2 in CD34+ cells cultured in a high foetal haemoglobin enriched condition. Given the inverse correlation between ZHX2 and the γ-globin gene in CD34+, our findings not only supports the idea that ZHX2 is involved in the repression of γ-globin gene but also provides evidence that ZHX2 has a direct effect on the γ-globin expression level and might participate in globin gene regulation.…”
Section: Zhx2 and γ-Globin Gene Expression Profile In K562mentioning
confidence: 75%