Expression of IL-1, IL-6, TNF-α, and iNOS in pregnant women with periodontal disease

Otenio, Cristiane Corsini Medeiros; Fonseca, Isabel; Martins, Marta Fonseca; Ribeiro, Luana Carneiro; Assis, Neuza Maria Souza Picorelli; Ferreira, Ana Paula Oliveira; Ribeiro, Ronaldo A.

doi:10.4238/2012.september.20.3

Cited by 28 publications

(30 citation statements)

References 40 publications

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“…In fact, during pregnancy, there are some changes in the interactions between periodontal microbiota and the host, which can be favorable for periodontal damage . Regarding the role of cytokines, expression levels of interleukins (IL‐1β and IL‐6), tumor necrosis factor‐α, and inducible nitric oxide synthesis were recently evaluated in pregnant women with and without periodontal disease compared to non‐pregnant women with and without periodontal disease, and it was found that this disease is not influenced by pregnancy …”

Section: Resultssupporting

confidence: 61%

Systemic alterations and their oral manifestations in pregnant women

Figueiredo

Rosalem

Cantanhede

et al. 2017

J of Obstet and Gynaecol

107

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The aims of this literature review are: to depict the main oral diseases that are related to pregnancy; to clarify some of the possible systemic mechanisms that are associated with these changes; and to address issues about oral care during pregnancy. A woman's organs undergo various physiological, neurological, and hormonal changes during pregnancy. Such changes occur gradually and are essential for the development of the fetus, providing what is needed for tissue formation and establishment of reserves for uterine and fetal life. In turn, the oral cavity shows some events during this period. Among the changes most frequently cited in the literature are pyogenic granuloma, gingivitis, and periodontitis. The inflammation of the periodontal tissues due to the formation of the biofilm increases dramatically in size and severity during the course of a normal pregnancy, even without changes in the amount of biofilm present. In addition, a decrease in salivary pH is observed in pregnant women and may lead to an increased incidence of dental caries in this period.

show abstract

Section: Resultssupporting

confidence: 61%

Systemic alterations and their oral manifestations in pregnant women

Figueiredo

Rosalem

Cantanhede

et al. 2017

J of Obstet and Gynaecol

107

View full text Add to dashboard Cite

show abstract

“…The resorption peak in the ligature‐induced periodontal disease model in rats is 15 days, 24 and, after this period, the bone level becomes constant, which may explain the lack of difference in the expression of certain genes between LG and CG observed in this study. Other researchers also found no difference in the expression of Mmp9 , Nos2 , and Timp1 among the groups with and without disease in periods longer than 15 days 25–28 . Increased expression of the Il1b gene in the group with periodontal disease compared with the control was observed, 26 , 29 and in this model and based on the present results, Il1b is the most important cytokine for assessing inflammation during the study period.…”

Section: Discussionsupporting

confidence: 66%

Exenatide and Sitagliptin Decrease Interleukin 1β, Matrix Metalloproteinase 9, and Nitric Oxide Synthase 2 Gene Expression But Does Not Reduce Alveolar Bone Loss in Rats With Periodontitis

Moraes

Lima

Oliveira

et al. 2015

Journal of Periodontology

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“…In periodontal disease, increased inflammation and bone loss is modulated by the proinflammatory cytokines Il-1, Il-6, and TNF-α [9], [10]. These inflammatory cytokines further activate the expression of metalloproteinases and RANKL, ultimately contributing to periodontal bone loss [11].…”

Section: Introductionmentioning

confidence: 99%

Atorvastatin Decreases Bone Loss, Inflammation and Oxidative Stress in Experimental Periodontitis

et al. 2013

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The aim of this study is to determine the effects of Atorvastatin treatment, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, in periodontal disease. Male Wistar albino rats were randomly divided into five groups of ten rats each: (1) non-ligated treatment (NL), (2) ligature only (L), (3) ligature plus 1 mg/kg Atorvastatin daily for 10 days, (4) ligature plus 5 mg/kg Atorvastatin daily for 10 days, and (5) ligature plus 10 mg/kg Atorvastatin daily for 10 days. Following the treatment course, the periodontal tissue of the animals was analyzed by Measurement of alveolar bone loss, Histopathology and immunohistochemistry to determine of the expression of COX-2, MMP-2, MMP9, and RANKL/RANK/OPG. ELISA assay was used to quantitate the levels of IL-1β, IL-10, TNF-α, myeloperoxidase, malondialdehyde, and glutathione. The periodontal group treated with 10 mg/kg of Atorvastatin (3.9±0.9 mm; p<0.05) showed reverse the alveolar bone loss caused Experimental Periodontal Disease compared to (L) (7.02±0.17 mm). The periodontal group treated with 10 mg/kg of Atorvastatin showed a significant reduction in MPO and MDA (p<0.05) compared to ligature only group (L). Similarly in this group, the levels of the proinflammatory cytokines IL-1β and TNF-α were significantly decreased (p<0.05). Furthermore, MMP-2, MMP-9, RANKL/RANK, and COX-2 were all downregulated by Atorvastatin treatment, while OPG expression was increased. The findings support a role of Atorvastatin for reducing the bone loss, inflammatory response, oxidative stress, and expression of extracellular matrix proteins, while reducing RANK/RANKL and increase OPG in periodontal disease.

show abstract

Expression of IL-1, IL-6, TNF-α, and iNOS in pregnant women with periodontal disease

Cited by 28 publications

References 40 publications

Systemic alterations and their oral manifestations in pregnant women

Systemic alterations and their oral manifestations in pregnant women

Exenatide and Sitagliptin Decrease Interleukin 1β, Matrix Metalloproteinase 9, and Nitric Oxide Synthase 2 Gene Expression But Does Not Reduce Alveolar Bone Loss in Rats With Periodontitis

Atorvastatin Decreases Bone Loss, Inflammation and Oxidative Stress in Experimental Periodontitis

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