Expression of ICAM-1, VCAM-1, E-selectin and TNF-α on the endothelium of femoral and iliac arteries in thromboangiitis obliterans

Halacheva, Krasimira; Gulubova, Maya; Manolova, Irena; Petkov, Dimitar

doi:10.1078/0065-1281-00621

Cited by 48 publications

(40 citation statements)

References 34 publications

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“…Smoking may exacerbate Buerger disease by inducing vasoconstriction and increasing platelet thrombosis [10], and also increase periodontal disease through altering the host immune response to periodontal pathogens [11]. Halacheva et al reported that the expression of ICAM-1, VCAM-1 and Eselectin were increased in the endothelium of Buerger disease patients [12]. P. gingivalis has been demonstrated to stimulate the expression of cell adhesion molecules such as ICAM-1, VCAM-1, P-selectin and E-selectin in endothelial cells [13].…”

Section: Discussionmentioning

confidence: 98%

Elevated IgG titers to periodontal pathogens related to Buerger disease

Chen

Iwai

Umeda

et al. 2007

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 98%

Elevated IgG titers to periodontal pathogens related to Buerger disease

Chen

Iwai

Umeda

et al. 2007

International Journal of Cardiology

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“…In another study, among the infiltrating cells, Thelper cells outnumbered cytotoxic T cells and the expression of VCAM-1 as well as iNOS were observed in endothelial cells around the intima or occluded segment [18]. In an immunohistochemical light and electron microscopical study to analyze the expression of TNFα, ICAM-1, VCAM-1 and Eselectin in surgical biopsies obtained from femoral and iliac arteries of patients with TAO, it is indicated that endothelial cells are activated in TAO and that vascular lesions are associated with TNFα secretion by tissue-infiltrating inflammatory cells [36]. Kurata et al presented histological and immunohistochemical characteristics of TAO that would be helpful in a differential diagnosis from arteriosclerosis obliterans (ASO) and thromboembolism [6,7].…”

Section: Discussionmentioning

confidence: 99%

Targeting novel antigens in the arterial wall in thromboangiitis obliterans.

Güzel

Topal²,

Yıldırım³

et al. 2010

Folia Histochem Cytobiol.

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Abstract:Thromboangiitis obliterans is an inflammatory disease possibly resulting from cigarette smoking as a primary etiologic factor, perhaps as a delayed type of hypersensitivity or toxic angiitis. As little is known about the pathogenesis of the disease, we aimed to determine novel antigens that might be responsible from the local inflammatory reactions and structural changes observed in this disease. An indirect immunoperoxidase technique is used to examine the tissue samples obtained from the dorsalis pedis artery of affected individuals with twenty monoclonal antibodies. Among these several antigens which are not previously reported in TAO like CD34, CD44 and CD90 were determined in the tissue samples examined. On the other hand, many other antigens like cytokine/chemokine receptors, several enzymes and leukocyte/lymphocyte antigens were lacking giving some clues about the local pathological reactions. We briefly discussed our findings for several critical antigens those first described in the present work, possibly having roles in the development of the disease. Expression of the CD90/CD11c receptor/ligand pair seems to play an important role in mononuclear cell recruitment to the damage site. Vascular invasion of not only tunica intima but also the tunica media in affected vessels is clearly demonstrated using endothelial cell specific antigens.

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“…B. in Deutschland das Rauchen auf offener Straße untersagt. Nachdem der Tabak zuerst in Pfeifen und in Form von Zigarren konsumiert wurde, erfolgte im 19. Jahrhundert die Massenproduktion der Zigarette und damit die rasche Ausbreitung des Nikotinkonsums.…”

Section: Willkommen Zur Zertifizierten Fortbildung Bei Springer!unclassified

“…4 Digitale Subtraktionsangiographie einer Hand bei Thrombangiitis obliterans hen Umfang mit der Tumor-Nekrose-Faktor-alpha-(TNF-alpha-) Sekretion durch gewebsinfiltrierende Entzündungszellen assoziiert zu sein.Die Leukozytenadhäsion wird dabei über eine gesteigerte Expression von Adhäsionsmolekülen (Selektine, "Intercellular Adhesion Molecule-1"=ICAM-1 und "Vascular Cell Adhesion Molecule-1"= VCAM-1) der Endothelzellen gesteuert [19].…”

Section: Der Hautarzt 3 · 2004 | 309unclassified

Tabakabh�ngigkeit und die Folgen auf die Haut

Krug¹,

Wünsche²,

Blum³

2004

Der Hautarzt

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Consumption of tobacco is hazardous to the health. It leads to cardiovascular diseases, and increases the incidence of numerous neoplasms. The adverse effects on the skin are less well-known and often ignored. Changes in the rheologic characteristics of the blood, increased vasoconstriction and damage to the epithelial layer of the vessel play an important pathogenic role in impaired wound healing, thromboangiitis obliterans and peripheral arterial obstructive diseases. Interactions with collagen metabolism are of special significance in wound healing and skin aging. The immunological effects, such as the induction of an inflammation reaction play a role in palmoplantar pustulosis, psoriasis, atopic dermatitis, acne vulgaris, acne inversa, thromboangiitis obliterans and lupus erythematodes. In addition, immunosuppression caused by nicotine consumption may contribute to the pathogenesis of human papilloma-virus infections, malignant melanoma and epithelial tumors of the skin and neighboring mucous membranes.

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Expression of ICAM-1, VCAM-1, E-selectin and TNF-α on the endothelium of femoral and iliac arteries in thromboangiitis obliterans

Cited by 48 publications

References 34 publications

Elevated IgG titers to periodontal pathogens related to Buerger disease

Elevated IgG titers to periodontal pathogens related to Buerger disease

Targeting novel antigens in the arterial wall in thromboangiitis obliterans.

Tabakabh�ngigkeit und die Folgen auf die Haut

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