Tabakabh�ngigkeit und die Folgen auf die Haut

Abstract

Consumption of tobacco is hazardous to the health. It leads to cardiovascular diseases, and increases the incidence of numerous neoplasms. The adverse effects on the skin are less well-known and often ignored. Changes in the rheologic characteristics of the blood, increased vasoconstriction and damage to the epithelial layer of the vessel play an important pathogenic role in impaired wound healing, thromboangiitis obliterans and peripheral arterial obstructive diseases. Interactions with collagen metabolism are of special significance in wound healing and skin aging. The immunological effects, such as the induction of an inflammation reaction play a role in palmoplantar pustulosis, psoriasis, atopic dermatitis, acne vulgaris, acne inversa, thromboangiitis obliterans and lupus erythematodes. In addition, immunosuppression caused by nicotine consumption may contribute to the pathogenesis of human papilloma-virus infections, malignant melanoma and epithelial tumors of the skin and neighboring mucous membranes.

Fine specificity of the Ro/SSA autoantibody response in relation to serological and clinical findings in 96 patients with self-reported cutaneous symptoms induced by the sun

“…24 Tobacco also has adverse effects on the skin and appears as an aggravating factor in skin diseases such as psoriasis, atopic dermatitis, acne, lichen and lupus. [25][26][27][28] Furthermore, patients are less responsive to treatment with anti-malarials if they are smokers. 29 Our results thus suggest that the pSS patients are more aware of the risk factor of cigarette smoking than the lupus patients, and that non-smoking advice should be a part in patient councelling especially in lupus patients.…”

Induction of Pustular Lesions During Infliximab Therapy for Crohn's Disease

“…Speculatively it could be the result of cytokine disequilibrium in patients on this treatment (5). A possible role of smoking has been suggested by some authors (6).…”

Skin in old age

“…Die Erkrankungen der Haut sind vielfältig (Tab.2) (2,4,5,7,9,10). Im Folgenden werden die häufigsten dermatologischen Erkrankungen mit den jeweiligen Therapieoptionen besprochen.…”

“…Zu den intrinsischen Ursachen sind ebenfalls die hormonellen Einflüsse zu nennen, die in gewissen Maßen beeinflussbar sind. Die extrinsische Alterung hängt überwiegend stark von der kumulativen UV-Exposition und dem Nikotinkonsum ab (1,7). Kommen beide Faktoren über einen langen Zeitraum zusammen, resultiert eine deutliche vorzeitige Hautalterung.…”