Elevated IgG titers to periodontal pathogens related to Buerger disease

Are There Any Objections against Our Hypothesis That Buerger Disease Is an Infectious Disease?

“…In addition, we found the possible transportation system of the oral bacteria dwelling in the platelet, 5) and we also knew that the oral bacteria aggregates platelets very strongly. 5) A genetic study, 6) epidemiologic factors, 7) and an antibody titer study 8) supported our hypothesis.…”

Buerger Disease, Smoking, and Periodontitis

“…Chen et al . reported that the antibody titer for periodontal bacteria is significantly elevated in Buerger disease patients, 14) reconfirming that Buerger disease patients have a very poor periodontal environs 9) ( Fig. 3 ).…”

IL-17 in Sera from Patients with Aggressive Periodontitis

“…We have previously observed that GAgP patients demonstrate elevated levels of anti-phospholipid antibodies such as anti-phosphorylcholine and β2-glycoproteindependent anti-cardiolipin (aCL), and that GAgP patients with elevated aCL also demonstrate elevated systemic markers of vascular inflammation (Schenkein et al, 2003(Schenkein et al, , 2007. The sources of such antibodies are unknown; they may be genuine autoantibodies, or they may be produced via molecular mimicry following exposure to cross-reactive periodontal bacterial pathogens (Chen et al, 2007(Chen et al, , 2009). The involvement of such antibodies in the pathogenesis of AgP is also not known.…”