Expression of histo-blood group antigens in bronchial squamous metaplasia

Abstract

The aim of the present study was to evaluate the expression of blood group antigens in squamous bronchial metaplasia in order to determine whether this factor could identify patients at risk of lung cancer.In total, 100 bronchial biopsies were included in the present study. The cases were classified according to the World Health Organization grading system. Immunohistochemical stains for histo-blood groups A and B, and reactivity tests to p53 and the cellular proliferation index were performed.A total of 56 (56%) patients belonged to blood group A. Among them, six (10.7%) patients who did not express antigen in squamous metaplasia, showed carcinoma at the moment of the biopsy (n53) or developed synchronous lung carcinoma (n53). A total of nine (9%) patients belonged to blood group B. Loss of antigenic expression was observed in five cases. All of them developed synchronous lung carcinoma. The patients with low-and high-grade dysplasia developed lung cancer in 71 and 100% of the cases, respectively.In conclusion, the findings of the present study suggest that the loss of histo-blood antigens expression is an event in the carcinogenesis of bronchial mucosa and it is usually associated with high-grade lesions and hyperproliferative activity.

Association of ABO Blood Group and Risk of Lung Cancer in a Multicenter Study in Turkey

“…In addition, various cancer cells express blood group antigens on their cell surface. In human lung cancer tissues, alterations of ABO antigen expression have been reported (Alvarez-Fernandez and Carretero-Albinana, 1991; Lee et al, 1991;Cerny et al, 1992;Miyake et al, 1992;Gwin et al, 1994;Rice et al, 1995;Graziano et al, 1997;Ulger et al, 2002;Sanchez-Mora et al, 2007;Leon-Atance et al, 2012).…”

Analysis of The Relationship between Blood Groups and Lung Cancer Risk Depending on Histology

“…gastric, pancreatic, ovarian, colorectal and renal cancers) were detected. Some studies were conducted to review the relation of lung cancer risk with blood groups as well as survival rates; however, the number of studies are less to provide reliable data (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). The correlation between histological types of lung cancer and blood types is not yet clarified.…”

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“…To be more specific an association between inherited human ABO blood group antigens with diseases such as coronary heart disease [6], ischemic stroke [7,8] and several types of malignancies [9] including pancreatic cancer [10][11][12], renal cell carcinoma [13], ovarian cancer [14], colorectal cancer [15,16], gastric cancer [17,18], hematological malignancies [19] and lung cancer was recorded. However, the data on the role of ABO blood group factor in lung cancer is limited and inconsistent [2,[20][21][22][23].…”